The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study

Meta-analysis in clinical trials

1986 • 36,193 citations

Cochrane Handbook for Systematic Reviews of Interventions

2008 • 18,785 citations

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

2008 • 16,541 citations

Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study

2008 • 2,367 citations

GRADE guidelines 6. Rating the quality of evidence—imprecision

2011 • 2,205 citations

Trial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis

2007 • 1,592 citations

Trial sequential analysis reveals insufficient information size and potentially false positive results in many meta-analyses

2008 • 948 citations

Estimating required information size by quantifying diversity in random-effects model meta-analyses

2009 • 845 citations

Apparently conclusive meta-analyses may be inconclusive—Trial sequential analysis adjustment of random error risk due to repetitive testing of accumulating data in apparently conclusive neonatal meta-analyses

2008 • 824 citations

Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses?

2008 • 755 citations

Users' Guides to the Medical Literature

2000 • 726 citations

Overcoming the limitations of current meta-analysis of randomised controlled trials

1998 • 431 citations

How strong is the evidence for the use of perioperative β blockers in non-cardiac surgery? Systematic review and meta-analysis of randomised controlled trials

2005 • 430 citations

Cumulating evidence from randomized trials: Utilizing sequential monitoring boundaries for cumulative meta-analysis

1997 • 385 citations

Meta-analysis of randomised controlled trials

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Cumulative meta-analysis of clinical trials builds evidence for exemplary medical care

1995 • 349 citations

Sequential methods for random‐effects meta‐analysis

2010 • 238 citations

Simple Heterogeneity Variance Estimation for Meta-Analysis

2005 • 208 citations

Evolution of treatment effects over time: Empirical insight from recursive cumulative metaanalyses

2001 • 185 citations

Effect sizes in cumulative meta-analyses of mental health randomized trials evolved over time

2004 • 175 citations

Statistically significant meta-analyses of clinical trials have modest credibility and inflated effects

2011 • 142 citations

Updating meta-analyses leads to larger type I errors than publication bias

2009 • 93 citations

The fading of reported effectiveness. A meta-analysis of randomised controlled trials

2006 • 83 citations

Uncertainty of the time of first significance in random effects cumulative meta-analysis

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Sequential meta-analysis: an efficient decision-making tool

2010 • 46 citations

“Fading of Reported Effectiveness” Bias: Longitudinal Meta-Analysis of Randomized Controlled Trials

2007 • 2 citations