Autoradiographic characterization of [3H]imipramine and [3H]citalopram binding in rat and human brain: species differences and relationships to serotonin innervation patterns

Statistical principles in experimental design.

1962 • 27,228 citations

Statistical Principles in Experimental Design

1964 • 8,376 citations

Behavioural despair in rats: A new model sensitive to antidepressant treatments

1978 • 3,035 citations

Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients

1984 • 1,490 citations

Neurobiology of the hippocampus

1984 • 1,096 citations

The Neurobiology of the Amygdala

1972 • 817 citations

The Dexamethasone Suppression Test for Melancholia

1982 • 774 citations

The Dexamethasone Suppression Test for Diagnosis and Prognosis in Psychiatry

1985 • 530 citations

Effect of 6-hydroxydopamine on brain norepinephrine and dopamine evidence for selective degeneration of catecholamine neurons.

1970 • 486 citations

Immunocytochemical localization of corticotropin‐releasing factor (CRF) in the rat brain

1982 • 405 citations

Pretreatment DST and Hypothalamic-Pituitary-Adrenocortical Function in Depressed Patients and Comparison Groups

1984 • 374 citations

CSF corticotropin-releasing factor-like immunoreactivity in depression and schizophrenia

1987 • 339 citations

Corticotropin releasing factor‐like immunoreactivity in the rat brain as revealed by a modified cobalt‐glucose oxidase‐diaminobenzidine method

1987 • 332 citations

Urinary free Cortisol excretion in depression

1976 • 310 citations

Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine.

1987 • 264 citations

Uptake inhibition of biogenic amines by newer antidepressant drugs: Relevance to the dopamine hypothesis of depression

1977 • 264 citations

Cortisol Secretion in Endogenous Depression

1985 • 257 citations

SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).

1964 • 234 citations

Autoradiography of antidepressant binding sites in the human brain: localization using [3h]imipramine and [3h]paroxetine

1988 • 219 citations

Developmental characteristics of brain catecholamines and tyrosine hydroxylase in the rat: effects of 6‐hydroxydopamine

1972 • 204 citations

Topics in psychoendocrinology

1976 • 204 citations

Antidepressant binding sites in brain: autoradiographic comparison of [3H]paroxetine and [3H]imipramine localization and relationship to serotonin transporter.

1990 • 185 citations

Serotonergic Stimulation of Pituitary-Adrenocortical Function in Rats

1981 • 185 citations

Neuroendocrine Effects ofM-Chlorophenylpiperazine, a Serotonin Agonist, in Humans

1985 • 181 citations

High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue

1989 • 166 citations

Behavioral and biochemical interactions of 5,7-dihydroxy-tryptamine with various drugs when administered intracisternally to adult and developing rats

1975 • 166 citations

Binding of 63H9imimipramine and 63H9desipramine as biochemical tools for studies in depression

1983 • 154 citations

The organization of serotonergic projections to cerebral cortex in primates: Regional distribution of axon terminals

1991 • 148 citations

Dexamethasone suppression test: a review of contemporary confusion.

1985 • 139 citations

Autoradiographic localization of ³H‐paroxetine‐labeled serotonin uptake sites in rat brain

1987 • 129 citations

α1-adrenoceptors in the mammalian brain: similar pharmacology but different distribution in rodents and primates

1987 • 126 citations

Differential Effects of Serotonin (5-HT<sub>1A</sub> and 5-HT<sub>2</sub>) Agonists and Antagonists on Renin and Corticosterone Secretion

1987 • 119 citations

Psychoneuroendocrinology of affective disorder: an overview

1977 • 111 citations

Neuropharmacology of the Affective Disorders

1973 • 104 citations

Distribution of Specific High‐Affinity Binding Sites for [³H]Imipramine in Human Brain

1981 • 104 citations

Serotonergic innervation of the rat caudate following a neonatal 6-hydroxydopamine lesion: An anatomical, biochemical and pharmacological study

1989 • 103 citations

Differences in plasma ACTH and cortisol between depressed patients and normal controls

1985 • 101 citations

Serotonergic Stimulation of Adrenocorticotropin Secretion in Man*

1984 • 98 citations

Single-site model of the neuronal 5-hydroxytryptamine uptake and imipramine-binding site.

1986 • 80 citations

Paraventricular nucleus serotonin mediates neurally stimulated adrenocortical secretion

1987 • 79 citations

Quantitative autoradiographic localization of [3H]imipramine binding sites in the brain of the rat: relationship to ascending 5-hydroxytryptamine neuron systems.

1983 • 78 citations

Preferential reduction of binding of 125I-iodopindolol to beta-1 adrenoceptors in the amygdala of rat after antidepressant treatments.

1991 • 77 citations

Differentiation of two components of specific [3H]imipramine binding in rat brain

1984 • 76 citations

High and low affinity [3H]imipramine binding sites in control and Parkinsonian brains

1985 • 74 citations

Association of [³H]-Imipramine and [³H]-Paroxetine Binding with the 5Ht Transporter in Brain and Platelets Relevance to Studies in Depression

1987 • 74 citations

Regional distribution of the serotonin transport complex in human brain, identified with 3H-Paroxetine, 3H-Citalopram and 3H-Imipramine

1990 • 73 citations

The total fate of a drug: kinetics of distribution, excretion, and formation of 14 metabolites in rats treated with imipramine.

1968 • 71 citations

Serotonergic Stimulation of Prolactin and Corticosterone Secretion Is Mediated by Different Pathways from the Mediobasal Hypothalamus

1985 • 71 citations

Effects of antidepressant drugs injected into the amygdala on behavioral responses of rats in the forced swim test.

1986 • 69 citations

Mapping receptors in the human brain

1986 • 68 citations

Neuroendocrine abnormalities in depressive illness.

1982 • 67 citations

Cholecystokinin-octapeptide (CCK-8) receptors in the hippocampal region: a comparative in vitro autoradiographic study in the rat, monkey and the postmortem human brain

1988 • 65 citations

Immunohistochemical demonstration of the localization of corticotropin releasing factor-containing neurons in the hypothalamus of mammals including primates

1982 • 51 citations

Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake.

1990 • 48 citations

Regionally specific neural adaptation of beta adrenergic and 5-hydroxytryptamine2 receptors after antidepressant administration in the forced swim test and after chronic antidepressant drug treatment.

1988 • 47 citations

Autoradiographic Analysis of [³H]Imipramine Binding in the Human Brain Postmortem: Effects of Age and Alcohol

1988 • 45 citations

Autoradiographic localization of [3H]-imipramine binding sites: Association with serotonergic neurons

1983 • 40 citations

β-Adrenergic receptor distribution in human and rat hippocampal formation: marked species differences

1991 • 39 citations

Citalopram

1982 • 36 citations

Site of fast, rate-sensitive feedback inhibition of adrenocorticotropin secretion during stress

1978 • 35 citations

High‐ and Low‐Affinity Binding Components for [³H]Imipramine in Rat Cerebral Cortex

1985 • 35 citations

Subdivision of Mouse Brain [³H]Imipramine Binding Based on Ion Dependence and Serotonin Sensitivity

1986 • 35 citations

Effects of imipramine upon hypothalamic and amygdaloid excitability

1961 • 34 citations

The regional distribution of dopamine and serotonin uptake and transmitter concentrations in the human brain

1987 • 33 citations

[3H]Impramine binding in subcellular fractions of rat cerebral cortex after chemical lesion of serotonergic neurons

1983 • 32 citations

Citalopram — A specific 5-HT-reuptake inhibitor — As an antidepressant drug: A phase II multicentre trial

1982 • 31 citations

Distribution of imipramine binding sites in the rat brain studied by quantitative autoradiography

1983 • 30 citations

High affinity [3H]desipramine binding in rat cerebral cortex decreases after selective lesion of noradrenergic neurons with 6-hydroxydopamine

1981 • 30 citations

The effect of unilateral amygdala lesion on the imipramine action in behavioural despair in rats

1979 • 28 citations

High‐ and Low‐Affinity Binding of [³H]Imipramine in Rat Hypothalamus

1986 • 27 citations

Effect of central serotonin depletion on adrenocortical responses to neural stimuli

1984 • 27 citations

Examination of the relationship between the uptake system for 5-hydroxytryptamine and the high-affinity [3H]imipramine binding site—I Inhibition by drugs

1986 • 26 citations

The Difference in the Site of Actions of Tricyclic Antidepressants and Methamphetamine on the Duration of the Immobility in the Behavioral Despair Test

1984 • 24 citations

Localization of [3H]-imipramine binding sites in rat brain by light microscopic autoradiography

1983 • 22 citations

Neuroanatomically selective down-regulation of beta adrenergic receptors by chronic imipramine treatment: relationships to the topography of [3H]imipramine and [3H] desipramine binding sites.

1989 • 21 citations

Serotonergic stimulation of pituitary-adrenocortical activity in rats: Evidence for multiple sites of action

1984 • 20 citations

Sodium-dependent [³H]imipramine binding in rat hippocampus and its relationship to serotonin uptake

1987 • 16 citations

Autoradiographic analysis of the in vivo distribution of 3H-imipramine and 3H-desipramine in brain: Comparison to in vitro binding patterns

1991 • 10 citations

Urinary free cortisol levels and dexamethasone suppression testing in organic affective disorder associated with hyperthyroidism

1985 • 10 citations

The importance of the amygdala in the effect of antidepressants on olfactory bulbectomised rats.

1982 • 3 citations

Localization of adrenergic receptors and CRH in human hypothalamus

1990 • 2 citations