Heparin-binding growth factors and their receptors

Angiogenic Factors

1987 • 3,702 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Mesoderm induction in early Xenopus embryos by heparin-binding growth factors

1987 • 953 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

Synergistic induction of mesoderm by FGF and TGF-β and the identification of an mRNA coding for FGF in the early xenopus embryo

1987 • 883 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Purification and characterization of a newly identified growth factor specific for epithelial cells.

1989 • 842 citations

Endothelial cell-derived heparan sulfate binds basic fibroblast growth factor and protects it from proteolytic degradation.

1988 • 810 citations

Teratocarcinomas and Mammalian Embryogenesis

1980 • 767 citations

Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension.

1986 • 741 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Purification and Complementary DNA Cloning of a Receptor for Basic Fibroblast Growth Factor

1989 • 660 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Isolation of a Novel Receptor cDNA Establishes the Existence of Two PDGF Receptor Genes

1989 • 610 citations

Two Classes of PDGF Receptor Eecognize Different Isoforms of PDGF

1988 • 603 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Binding of different dimeric forms of PDGF to human fibroblasts: evidence for two separate receptor types.

1988 • 514 citations

Basic fibroblast growth factor from human keratinocytes is a natural mitogen for melanocytes.

1988 • 489 citations

Growth factor control of skeletal muscle differentiation: commitment to terminal differentiation occurs in G1 phase and is repressed by fibroblast growth factor.

1987 • 480 citations

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

1989 • 469 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

The Presence of Fibroblast Growth Factor in the Frog Egg: Its Role as a Natural Mesoderm Inducer

1988 • 367 citations

The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells.

1985 • 352 citations

Molecular Characterization of Fibroblast Growth Factor: Distribution and Biological Activities in Various Tissues

1986 • 340 citations

Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

1986 • 340 citations

Polypeptide Growth Factors: Roles In Normal And Abnormal Cell Growth

1987 • 339 citations

Fibroblast growth factor: Structural and biological properties

1987 • 334 citations

Interaction of endothelial cell growth factor with heparin: characterization by receptor and antibody recognition.

1985 • 301 citations

Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography

1984 • 298 citations

Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

1989 • 294 citations

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity.

1987 • 293 citations

Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts

1986 • 285 citations

Purification of heparin-binding growth factors

1986 • 279 citations

Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells.

1988 • 276 citations

The effect of fibroblast growth factor on PC12 cells

1985 • 270 citations

Purification and characterization of acidic fibroblast growth factor from bovine brain.

1984 • 267 citations

Fibroblast Growth Factor in the Extracellular Matrix of Dystrophic (mdx) Mouse Muscle

1989 • 263 citations

Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo.

1988 • 261 citations

Myogenic differentiation in permanent clonal mouse myoblast cell lines: Regulation by macromolecular growth factors in the culture medium

1981 • 259 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Isolation and partial molecular characterization of pituitary fibroblast growth factor.

1984 • 225 citations

Cell surface fibroblast growth factor and epidermal growth factor receptors are permanently lost during skeletal muscle terminal differentiation in culture.

1988 • 197 citations

Heparin potentiates the action of acidic fibroblast growth factor by prolonging its biological half‐life

1989 • 181 citations

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.

1986 • 178 citations

Cancer cells. 3: Growth factors and transformation

1985 • 176 citations

Growth of normal human keratinocytes and fibroblasts in serum‐free medium is stimulated by acidic and basic fibroblast growth factor

1989 • 174 citations

Specific binding of basic fibroblast growth factor to basement membrane‐like structures and to purified heparan sulfate proteoglycan of the EHS tumor

1988 • 172 citations

Basic fibroblast growth factor in the chick embryo: immunolocalization to striated muscle cells and their precursors.

1989 • 172 citations

Heparin modulation of the neurotropic effects of acidic and basic fibroblast growth factors and nerve growth factor on PC12 cells

1987 • 163 citations

Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF

1989 • 154 citations

Association of bovine brain-derived growth factor receptor with protein tyrosine kinase activity.

1986 • 151 citations

Transformation of mouse BALB/c 3T3 cells with human basic fibroblast growth factor cDNA.

1988 • 150 citations

Induction of protein kinase C activation and Ca²⁺ mobilization by fibroblast growth factor in Swiss 3T3 cells

1985 • 148 citations

The neuronal cell-surface molecule mitogenic for Schwann cells is a heparin-binding protein.

1988 • 134 citations

Expression of human basic fibroblast growth factor cDNA in baby hamster kidney-derived cells results in autonomous cell growth.

1988 • 134 citations

Multiple RNAs expressed from the int-2 gene in mouse embryonal carcinoma cell lines encode a protein with homology to fibroblast growth factors.

1988 • 130 citations

Heparin-binding growth factor gene expression and receptor characteristics in normal rat prostate and two transplantable rat prostate tumors.

1989 • 127 citations

High and low affinity binding of heparin-binding growth factor to a 130-kDa receptor correlates with stimulation and inhibition of growth of a differentiated human hepatoma cell.

1988 • 126 citations

Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.

1987 • 117 citations

Characterization of the Neuronal Receptor for Basic Fibroblast Growth Factor and Comparison to Receptors on Mesenchymal Cells

1989 • 113 citations

Glycosylation of the basic fibroblast growth factor receptor. The contribution of carbohydrate to receptor function.

1988 • 112 citations

The characterization of the receptor for endothelial cell growth factor by covalent ligand attachment.

1986 • 111 citations

Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells.

1986 • 105 citations

Control of myogenic differentiation by fibroblast growth factor is mediated by position in the G1 phase of the cell cycle.

1985 • 99 citations

Fibroblast growth factor receptor levels decrease during chick embryogenesis.

1990 • 99 citations

Addition of growth hormone secretion signal to basic fibroblast growth factor results in cell transformation and secretion of aberrant forms of the protein.

1988 • 98 citations

Analysis of competence: receptors for fibroblast growth factor in early Xenopus embryos

1989 • 97 citations

Fibroblast growth factor treatment of Swiss 3T3 cells activates a subunit S6 kinase that phosphorylates a synthetic peptide substrate.

1986 • 96 citations

Isolation of a Receptor for Acidic and Basic Fibroblast Growth Factor from Embryonic Chick

1989 • 88 citations

Heparin-binding growth factor 1 stimulates tyrosine phosphorylation in NIH 3T3 cells.

1989 • 85 citations

Cell type and tissue distribution of the fibroblast growth factor receptor

1989 • 77 citations

Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor.

1988 • 77 citations

A growth factor-repressible gene associated with protein kinase C-mediated inhibition of adipocyte differentiation.

1988 • 73 citations

Bovine brain-derived growth factor. Purification and characterization of its interaction with responsive cells.

1986 • 69 citations

Purification of basic FGF receptors from rat brain

1988 • 63 citations

Production and utilization of growth factors related to fibroblast growth factor by embryonal carcinoma cells and their differentiated cells

1988 • 55 citations

Neutralizing antibodies inhibit the binding of basic fibroblast growth factor to its receptor but not to heparin

1989 • 48 citations

Effects of platelet‐derived growth factor and fibroblast growth factor on free intracellular calcium and mitogenesis

1989 • 46 citations

Comparative study of the tyrosine phosphorylation of proteins in Swiss 3T3 fibroblasts stimulated by a variety of mitogenic agents

1988 • 39 citations

Identification and isolation from bovine epithelial lens cells of two basic fibroblast growth factor receptors that possess bFGF-enhanced phosphorylation activities

1989 • 38 citations

Production of latent collagenase by human umbilical vein endothelial cells in response to angiogenic preparations

1985 • 38 citations

Presence of basic fibroblast growth factor receptors in bovine brain membranes.

1988 • 37 citations

Stimulation of polyphosphoinositide hydrolysis in Swiss 3T3 cells by recombinant fibroblast growth factors

1989 • 35 citations

Characterization of tumors produced by signal peptide‐basic fibroblast growth factor‐transformed cells

1989 • 30 citations

Expression of fibroblast growth factor by F9 teratocarcinoma cells as a function of differentiation.

1989 • 17 citations

Purification from human hepatoma cells of a 130-kDa membrane glycoprotein with properties of the heparin-binding growth factor receptor

1988 • 17 citations

Platelet‐derived growth factor or basic fibroblast growth factor induce anchorage‐independent growth of human fibroblasts

1988 • 11 citations

Production of growth factors related to fibroblast growth factor and platelet-derived growth factor by human embryonal carcinoma cells

1988 • 10 citations