Effects of interleukin-2 and interleukin-2-activated cells on in vitro myelopoiesis

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Human bone marrow colony growth in agar‐gel

1970 • 1,317 citations

Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2.

1985 • 737 citations

Dissection of the lymphokine-activated killer phenomenon. Relative contribution of peripheral blood natural killer cells and T lymphocytes to cytolysis.

1986 • 698 citations

Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets.

1983 • 483 citations

Evidence for a similar or common mechanism for natural killer cell activity and resistance to hemopoietic grafts

1977 • 467 citations

Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins.

1988 • 327 citations

Effects of natural and recombinant IL 2 on regulation of IFN gamma production and natural killer activity: lack of involvement of the Tac antigen for these immunoregulatory effects.

1984 • 310 citations

Capacity of human large granular lymphocytes (LGL) to produce multiple lymphokines: interleukin 2, interferon, and colony stimulating factor.

1983 • 294 citations

Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon.

1985 • 249 citations

Lymphokine-activated killer cell activity

1987 • 235 citations

Inhibition of in vitro granulopoiesis by autologous allogeneic human NK cells.

1982 • 199 citations

Isolation of human and rat natural killer cells

1982 • 169 citations

Hematologic effects of immunotherapy with lymphokine-activated killer cells and recombinant interleukin-2 in cancer patients

1987 • 166 citations

Human fetal thymus and bone marrow contain target cells for natural killer cells

1981 • 143 citations

Natural killer cells suppress human erythroid stem cell proliferation in vitro

1984 • 122 citations

Inhibition of bone marrow colony formation by human natural killer cells and by natural killer cell-derived colony-inhibiting activity.

1985 • 115 citations

Role of asialo-GM1-positive lymphoid cells in mediating the toxic effects of recombinant IL-2 in mice.

1988 • 81 citations

Effects of recombinant human tumor necrosis factor alpha, recombinant human gamma-interferon, and prostaglandin E on colony formation of human hematopoietic progenitor cells stimulated by natural human pluripotent colony-stimulating factor, pluripoietin alpha, and recombinant erythropoietin in serum-free cultures.

1986 • 69 citations

In vivo function of natural killer cells as regulators of myeloid precursor cells in the spleen

1988 • 45 citations

Natural immunity cancer and biological response modification

1986 • 45 citations

Effect of lymphokine-activated killer cell fraction on the development of human hematopoietic progenitor cells.

1988 • 41 citations

Noncytotoxic functions of natural killer (NK) cells: large granular lymphocytes (LGL) produce a B cell growth factor (BCGF).

1985 • 40 citations

The effects of recombinant interleukin 2-activated natural killer cells on autologous peripheral blood hematopoietic progenitors.

1988 • 34 citations

Selective generation of erythroid burst-promoting activity by recombinant interleukin 2-stimulated human T lymphocytes and natural killer cells

1988 • 29 citations

Receptor-specific inhibition of bone marrow erythropoiesis by recombinant DNA-derived interleukin-2

1987 • 24 citations

Production of interferon and tumour necrosis factor by cloned human natural cytotoxic lymphocytes and T cells.

1987 • 22 citations

IFN-gamma is not the only mediator of suppressed myelopoiesis produced by mononuclear cells from aplastic anemia patients.

1987 • 5 citations