A mechanism for rotamase catalysis by the FK506 binding protein (FKBP)

<scp>CHARMM</scp>: A program for macromolecular energy, minimization, and dynamics calculations

1983 • 14,615 citations

Protein folding in the cell

1992 • 4,138 citations

The mechanism of action of cyclosporin A and FK506

1992 • 2,127 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

The C-H.cntdot..cntdot..cntdot.O hydrogen bond in crystals: what is it?

1991 • 1,230 citations

Atomic Structures of the Human Immunophilin FKBP-12 Complexes with FK506 and Rapamycin

1993 • 1,202 citations

Influence of proline residues on protein conformation

1991 • 1,125 citations

Consideration of the possibility that the slow step in protein denaturation reactions is due to cis-trans isomerism of proline residues

1975 • 1,108 citations

pKa's of ionizable groups in proteins: atomic detail from a continuum electrostatic model

1990 • 1,056 citations

Atomic Structure of FKBP-FK506, an Immunophilin-Immunosuppressant Complex

1991 • 641 citations

FK506 binding protein associated with the calcium release channel (ryanodine receptor).

1992 • 525 citations

Occurrence and role ofcis peptide bonds in protein structures

1990 • 516 citations

Determination of kinetic constants for peptidyl prolyl cis-trans isomerases by an improved spectrophotometric assay

1991 • 506 citations

Conjugate peak refinement: an algorithm for finding reaction paths and accurate transition states in systems with many degrees of freedom

1992 • 472 citations

Barriers to rotation adjacent to double bonds. 3. The carbon-oxygen barrier in formic acid, methyl formate, acetic acid, and methyl acetate. The origin of ester and amide resonance

1987 • 445 citations

The mechanism of protein folding. Implications of in vitro refolding models for de novo protein folding and translocation in the cell

1990 • 372 citations

Substrate specificities of the peptidyl prolyl cis-trans isomerase activities of cyclophilin and FK-506 binding protein: evidence for the existence of a family of distinct enzymes

1990 • 303 citations

Energetics of charge–charge interactions in proteins

1988 • 279 citations

Computer simulation and analysis of the reaction pathway of triosephosphate isomerase

1991 • 265 citations

Inhibition of FKBP Rotamase Activity by Immunosuppressant FK506: Twisted Amide Surrogate

1990 • 199 citations

Ab initio studies of hydrogen bonding of N-methylacetamide: structure, cooperativity, and internal rotational barriers

1992 • 185 citations

Barrier to internal rotation in amides. IV. N,N-Dimethylamides. Substituent and solvent effects

1972 • 166 citations

Mechanistic studies of peptidyl prolyl cis-trans isomerase: evidence for catalysis by distortion

1990 • 164 citations

Isolation and sequence of an FK506-binding protein from N. crassa which catalyses protein folding

1990 • 160 citations

Mechanism of Enzymatic and Nonenzymatic Prolyl Cis-Trans Isomerization

1993 • 148 citations

Reaction path study of helix formation in tetrapeptides: Effect of side chains

1991 • 139 citations

The X‐ray structure of a tetrapeptide bound to the active site of human cyclophilin A

1992 • 129 citations

Charged surface residues of FKBP12 participate in formation of the FKBP12-FK506-calcineurin complex.

1992 • 126 citations

Substrate specificity for the human rotamase FKBP: a view of FK506 and rapamycin as leucine-(twisted amide)-proline mimics

1990 • 123 citations

Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl‐prolyl cis‐trans isomerases

1992 • 111 citations

Solvent effects on the energetics of prolyl peptide bond isomerization

1992 • 108 citations

PPIase catalysis by human FK506-binding protein proceeds through a conformational twist mechanism.

1992 • 105 citations

βVI Turns in peptides and proteins: A model peptide mimicry

1993 • 91 citations

Calculating electrostatic forces from grid‐calculated potentials

1990 • 86 citations

A composite FKBP12-FK506 surface that contacts calcineurin

1993 • 83 citations

Mechanistic studies of enzymic and nonenzymic prolyl cis-trans isomerization

1992 • 83 citations

Intramolecular catalysis of a proline isomerization reaction in the folding of dihydrofolate reductase

1992 • 75 citations

P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors

1993 • 60 citations

Peptidyl-prolyl cis-trans isomerases, cyclophilin, FK506-binding protein, and ninaA: Four of a kind

1990 • 25 citations

Nuclear magnetic resonance studies of the hindered internal rotation of NN-disubstituted amides. Part VII. Solvent effects on the N-methyl resonance shifts and activation parameters

1970 • 16 citations

Science and Anglo-American Relations1

1946 • 1 citations