Thimerosal Interacts with the Ca2+ Release Channel Ryanodine Receptor from Skeletal Muscle Sarcoplasmic Reticulum

Calcium Channels, Stores, and Oscillations

1990 • 1,208 citations

DIFFERENTIAL SPECTROPHOTOMETRY OF PURINE COMPOUNDS BY MEANS OF SPECIFIC ENZYMES

1947 • 1,124 citations

Purification and Properties of an Adenosine Triphosphatase from Sarcoplasmic Reticulum

1970 • 835 citations

Cytosolic calcium oscillators

1988 • 690 citations

Ca2+-activated ryanodine binding: mechanisms of sensitivity and intensity modulation by Mg2+, caffeine, and adenine nucleotides.

1987 • 314 citations

The thiol reagent, thimerosal, evokes Ca2+ spikes in HeLa cells by sensitizing the inositol 1,4,5-trisphosphate receptor.

1992 • 269 citations

Sulfhydryl oxidation induces rapid calcium release from sarcoplasmic reticulum vesicles.

1986 • 175 citations

Different triggers for calcium oscillations in mouse eggs involve a ryanodine-sensitive calcium store

1992 • 166 citations

Reactive disulfides trigger Ca2+ release from sarcoplasmic reticulum via an oxidation reaction

1989 • 158 citations

Ryanodine stabilizes multiple conformational states of the skeletal muscle calcium release channel.

1992 • 151 citations

Critical sulfhydryls regulate calcium release from sarcoplasmic reticulum

1989 • 149 citations

Luminal Ca2+ promoting spontaneous Ca2+ release from inositol trisphosphate‐sensitive stores in rat hepatocytes.

1992 • 138 citations

Mechanism of anthraquinone-induced calcium release from skeletal muscle sarcoplasmic reticulum.

1988 • 104 citations

Direct evidence for the existence and functional role of hyperreactive sulfhydryls on the ryanodine receptor-triadin complex selectively labeled by the coumarin maleimide 7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin.

1994 • 102 citations

Thiol reagents increase the affinity of the inositol 1,4,5-trisphosphate receptor

1993 • 97 citations

Molecular interaction between ryanodine receptor and glycoprotein triadin involves redox cycling of functionally important hyperreactive sulfhydryls

1994 • 92 citations

Antibody to the inositol trisphosphate receptor blocks thimerosalenhanced Ca²⁺‐induced Ca²⁺ release and Ca²⁺ oscillations in hamster eggs

1992 • 91 citations

Oxidized glutathione causes sensitization of calcium release to inositol 1,4,5-trisphosphate in permeabilized hepatocytes

1992 • 84 citations

Purified reconstituted inositol 1,4,5-trisphosphate receptors. Thiol reagents act directly on receptor protein.

1994 • 81 citations

The effects of thimerosal on calcium uptake and inositol 1,4,5-trisphosphate-induced calcium release in cerebellar microsomes

1993 • 78 citations

Thimerosal potentiates Ca2+ release mediated by both the inositol 1,4,5-trisphosphate and the ryanodine receptors in sea urchin eggs. Implications for mechanistic studies on Ca2+ signaling

1994 • 46 citations

Effect of oxidized glutathione and temperature on inositol 1,4,5-trisphosphate binding in permeabilized hepatocytes

1995 • 43 citations