Ligand-induced Desensitization of the Human CXC Chemokine Receptor-2 Is Modulated by Multiple Serine Residues in the Carboxyl-terminal Domain of the Receptor

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

The CXC Chemokines Growth-regulated Oncogene (GRO) α, GROβ, GROγ, Neutrophil-activating Peptide-2, and Epithelial Cell-derived Neutrophil-activating Peptide-78 Are Potent Agonists for the Type B, but Not the Type A, Human Interleukin-8 Receptor

1996 • 402 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

Regulation of the expression of IL-8 receptor A/B by IL-8: possible functions of each receptor.

1995 • 250 citations

Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration

1995 • 213 citations

Interleukin 8 (monocyte-derived neutrophil chemotactic factor) dynamically regulates its own receptor expression on human neutrophils.

1990 • 213 citations

Desensitization of the isolated .beta.2-adrenergic receptor by .beta.-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms

1992 • 187 citations

CXC Chemokines Bind to Unique Sets of Selectivity Determinants That Can Function Independently and Are Broadly Distributed on Multiple Domains of Human Interleukin-8 Receptor B

1996 • 151 citations

Monocyte Chemotactic Protein-3 (MCP3) Interacts with Multiple Leukocyte Receptors

1995 • 145 citations

The Cytoplasmic Tail of the G-protein-coupled Receptor for Parathyroid Hormone and Parathyroid Hormone-related Protein Contains Positive and Negative Signals for Endocytosis

1995 • 133 citations

Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1B-adrenergic receptor.

1994 • 132 citations

Stable Expression of a Truncated AT1A Receptor in CHO-K1 Cells

1995 • 129 citations

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

1994 • 129 citations

Cross-desensitization of Chemoattractant Receptors Occurs at Multiple Levels

1995 • 103 citations

Regulation of Human Interleukin-8 Receptor A: Identification of a Phosphorylation Site Involved in Modulating Receptor Functions

1995 • 92 citations

Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function.

1996 • 88 citations

Role of the C Terminus of the Interleukin 8 Receptor in Signal Transduction and Internalization

1996 • 69 citations

CHEMOATTRACTANT LIGANDS AND THEIR RECEPTORS

1997 • 65 citations

Melanoma growth stimulatory activity enhances the phosphorylation of the class II interleukin-8 receptor in non-hematopoietic cells.

1994 • 64 citations

Diverging Signal Transduction Pathways Activated by Interleukin 8 (IL-8) and Related Chemokines in Human Neutrophils

1996 • 60 citations

Receptor Up-regulation, Internalization, and Interconverting Receptor States

1996 • 47 citations

Activation of Protein Kinase C Enhances the Phosphorylation of the Type B Interleukin-8 Receptor and Stimulates Its Degradation in Non-hematopoietic Cells

1995 • 41 citations