Body Cholesterol Removal: Role of Plasma High-Density Lipoproteins1 1Supported by National Health Service Grants HL 18673, HL 07291, and HL 22682, and a Grant-In-Aid from the American Heart Association (316–3070–2286).
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References (247)
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Effects of Dietary Polyunsaturated and Saturated Fat on the Properties of High Density Lipoproteins and the Metabolism of Apolipoprotein A-I
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Role of Specific Glycopeptides of Human Serum Lipoproteins in the Activation of Lipoprotein Lipase
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High density lipoprotein distribution
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The interaction of cholesterol absorption and cholesterol synthesis in man
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Lipid-protein interactions in the plasma lipoproteins
1977 • 280 citations
Amino Acid Sequence of Human apoLp-Gln-II (apoA-II), an Apolipoprotein Isolated from the High-Density Lipoprotein Complex
1972 • 278 citations
Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding
1975 • 266 citations
Quantitative and qualitative serum lipoprotein analysis
1975 • 264 citations
The removal of cholesterol from aortic smooth muscle cells in culture and landschutz ascites cells by fractions of human high-density apolipoprotein
1975 • 264 citations
Rat Intestine Secretes Discoid High Density Lipoprotein
1978 • 264 citations
Lipoprotein Metabolism1 1In preparation of this study, Dr. Eisenberg was supported in part through the Special Foreign Currency Program of the National Library of Medicine, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, and Welfare, Bethesda, Maryland, under an agreement with the Israel Journal of Medical Sciences, Jerusalem, Israel.
1975 • 254 citations
Particle distribution of human serum high density lipoproteins
1977 • 254 citations
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: structure of low and high density lipoproteins as revealed by electron microscopy
1971 • 249 citations
Disintegration of phosphatidylcholine liposomes in plasma as a result of interaction with high-density lipoproteins
1978 • 248 citations
Human Intestinal Lipoproteins
1979 • 245 citations
Lipoproteins: Structure and Function
1975 • 244 citations
Canine Lipoproteins and Atherosclerosis
1974 • 243 citations
Quantitation of the Transfer of Surface Phospholipid of Chylomicrons to the High Density Lipoprotein Fraction during the Catabolism of Chylomicrons in the Rat
1979 • 239 citations
High-Density Lipoproteins and Atherosclerosis
1978 • 230 citations
Chylomicron remnant cholesteryl esters as the major constituent of very low density lipoproteins in plasma of cholesterol-fed rabbits
1977 • 224 citations
Metabolic Fate of Chylomicron Phospholipids and Apoproteins in the Rat
1979 • 219 citations
Kinetics of lipid-protein interactions: interaction of apolipoprotein A-I from human plasma high density lipoproteins with phosphatidylcholines
1978 • 212 citations
Apoprotein (E–A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction.
1978 • 211 citations
The intestine as a source of apolipoprotein A1.
1977 • 210 citations
Behavior of dog lymph chylomicron lipid constituents during incubation with serum
1963 • 210 citations
The nature of pre beta (very low density) lipoproteins.
1966 • 208 citations
Ternary and Quaternary Aqueous Systems Containing Bile Salt, Lecithin, and Cholesterol
1966 • 207 citations
Familial hyper-alpha-lipoproteinemia: Studies in eighteen kindreds
1975 • 207 citations
Cholestasis: Lamellar Structure of the Abnormal Human Serum Lipoprotein
1971 • 203 citations
EARLY EFFECTS OF FAT INGESTION ON LIPIDS AND LIPO-PROTEINS OF SERUM IN MAN
1957 • 203 citations
Canine Lipoproteins and Atherosclerosis
1974 • 201 citations
The Complete Amino Acid Sequence of Alanine Apolipoprotein (apoC-III), an Apolipoprotein from Human Plasma Very Low Density Lipoproteins
1974 • 197 citations
Cholesterol content and sterol synthesis in human skin fibroblasts and rat aortic smooth muscle cells exposed to lipoprotein-depleted serum and high density apolipoprotein/phospholipid mixtures
1976 • 196 citations
Surface Chemistry of Biological Systems
1970 • 192 citations
Structure and thermodynamic properties of high density lipoprotein recombinants.
1977 • 192 citations
Characterization of the apolipoproteins of rat plasma lipoproteins
1977 • 190 citations
Thermal Transitions in Human Plasma Low Density Lipoproteins
1975 • 188 citations
Very Low Density Lipoprotein
1978 • 186 citations
Human plasma lecithin-cholesterol acyltransferase. Characterization of cofactor-dependent phospholipase activity.
1978 • 180 citations
The biophysics of lipidic associations. I. The ternary systems: lecithin-bile salt-water.
1966 • 179 citations
Composition and structure of plasma lipoproteins. Separation and quantification of the lipoprotein families occurring in the high density lipoproteins of human plasma
1972 • 177 citations
Selective Deficiency of Hepatic Triglyceride Lipase in Uremic Patients
1977 • 175 citations
Quantitative studies of the metabolism of chylomicron triglycerides and cholesterol by liver and extrahepatic tissues of sheep and dogs
1971 • 173 citations
Quantitative and qualitative serum lipoprotein analysis
1975 • 173 citations
The Influence of Lipid on the Conformation of Human Plasma High Density Apolipoproteins
1972 • 172 citations
Serum high density lipoprotein in diabetic patients
1977 • 172 citations
SITES OF LIPOPROTEIN LIPASE ACTIVITY IN ADIPOSE TISSUE PERFUSED WITH CHYLOMICRONS
1971 • 168 citations
Human chylomicron apolipoprotein metabolism
1978 • 164 citations
Activation of lipoprotein lipase by native and synthetic fragments of human plasma apolipoprotein C-II.
1977 • 164 citations
Studies on the isolation and partial characterization of apolipoprotein D and lipoprotein D of human plasma
1976 • 163 citations
METABOLISM OF CONSTITUENT LIPIDS OF DOG CHYLOMICRONS*
1963 • 163 citations
Apoproteins of the lipoproteins in a nonrecirculating perfusate of rat liver
1976 • 161 citations
Secretion of the arginine-rich and A-I apolipoproteins by the isolated perfused rat liver
1977 • 160 citations
Application of electron microscopy to the study of plasma lipoprotein structure.
1972 • 160 citations
Regulation of cellular sterol flux and synthesis by human serum lipoproteins
1974 • 159 citations
The Enterohepatic Circulation of Bile Salts
1972 • 158 citations
Cellular Mechanisms for Lipid Deposition in Atherosclerosis
1977 • 155 citations
High density lipoproteins reduce the uptake of low density lipoproteins by human endothelial cells in culture
1976 • 154 citations
The biophysics of lipidic associations
1966 • 153 citations
Distribution of triglyceride and total, LDL and HDL cholesterol in several populations: A cooperative lipoprotein phenotyping study
1977 • 151 citations
Interaction of swine lipoproteins with the low density lipoprotein receptor in human fibroblasts.
1976 • 150 citations
Abnormal induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in leukocytes from subjects with heterozygous familial hypercholesterolemia.
1975 • 148 citations
Identification of circulating apolipoproteins synthesized by rat small intestine in vivo.
1978 • 147 citations
Radioimmunoassay of Human Apolipoprotein CII
1977 • 146 citations
SITES OF INITIAL REMOVAL OF CHYLOMICRON TRIGLYCERIDE FATTY ACIDS FROM THE BLOOD*
1962 • 143 citations
Metabolic fate of rat and human lipoprotein apoproteins in the rat
1973 • 143 citations
Abnormal Plasma Lipoproteins and Lecithin-Cholesterol Acyltransferase Deficiency in Alcoholic Liver Disease
1977 • 140 citations
Primary structure of very low density apolipoprotein C-II of human plasma.
1977 • 139 citations
Serum Lipoproteins Structure and Function
1972 • 138 citations
Studies on the Structure of Low Density Lipoproteins Isolated from Macaca Fascicularis Fed an Atherogenic Diet
1978 • 137 citations
Quantitative aspects of the intestinal absorption and metabolism of cholesterol and β-sitosterol in the rat
1968 • 136 citations
Intestinal apoproteins during fat absorption.
1978 • 135 citations
Characterization and quantitation of the apolipoproteins from human chyle chylomicrons
1972 • 134 citations
EFFECTS OF THERAPY ON PLASMA-HIGH-DENSITY-LIPOPROTEIN-CHOLESTEROL CONCENTRATION IN DIABETES MELLITUS
1978 • 132 citations
Application of Electron Microscopy to the Study of Plasma Lipoprotein Structure1 1This work was supported by Research Grants HE 12710–02 and HE 10878–05 from the National Heart and Lung Institute, U. S. Public Health Service, Bethesda, Maryland, and by the U. S. Atomic Energy Commission.
1972 • 131 citations
Electron microscopic study on reassembly of plasma high density apoprotein with various lipids
1971 • 129 citations
CHOLESTEROL METABOLISM IN THE MACROPHAGE
1972 • 128 citations
Interaction of canine and swine lipoproteins with the low density lipoprotein receptor of fibroblasts as correlated with heparin/manganese precipitability.
1977 • 127 citations
A comparative study on the removal of cellular lipids from Landschütz ascites cells by human plasma apolipoproteins.
1975 • 127 citations
Uptake of blood triglyceride by various tissues
1972 • 123 citations
Amphipathic helixes and plasma lipoproteins: Thermodynamic and geometric considerations
1977 • 122 citations
Effects of Ultracentrifugation on the Human Serum High-Density (1.063 < ρ < 1.21 g/ml) Lipoprotein*
1966 • 120 citations
Repeated helical pattern in apolipoprotein-A-I
1977 • 120 citations
Precipitation of iodine-125-labeled lipoproteins with specific polypeptide antisera. Evidence for two populations with differing polypeptide compositions in human high density lipoproteins
1971 • 120 citations
Interaction of rat plasma very low density lipoprotein with lipoprotein lipase-rich (postheparin) plasma.
1975 • 119 citations
Interaction between High Density and Low Density Lipoproteins during Uptake and Degradation by Cultured Human Fibroblasts
1977 • 119 citations
Metabolism of iodinated high density lipoproteins in the rat
1971 • 119 citations
Polypeptide Distribution of the Main Lipoprotein Density Classes Separated from Human Plasma by Rate Zonal Ultracentrifugation
1974 • 119 citations
The primary structure of human plasma high density apolipoprotein glutamine I (ApoA-I). II. The amino acid sequence and alignment of cyanogen bromide fragments IV, III, and I.
1975 • 118 citations
Low Density Lipoprotein
1978 • 117 citations
Apoprotein A-I Synthesis in Normal Intestinal Mucosa and in Tangier Disease
1978 • 115 citations
NORMAL SERUM-CHOLESTEROL BUT LOW H.D.L.-CHOLESTEROL CONCENTRATION IN YOUNG PATIENTS WITH ISCHÆMIC CEREBROVASCULAR DISEASE
1978 • 111 citations
Structure of human plasma low-density lipoproteins: molecular organization of the central core.
1977 • 111 citations
Cholesterol synthesis in the intestine of man: regional differences and control mechanisms
1971 • 111 citations
The Primary Structure of Apolipoprotein-Serine
1974 • 106 citations
A study of the abnormal lipoproteins in abetalipoproteinemia.
1974 • 104 citations
The effect of cholesterol incorporation on the temperature dependence of water permeation through liposomal membranes prepared from phosphatidylcholines
1977 • 103 citations
Biliary lipid outputs in young women with cholesterol gallstones
1974 • 103 citations
Conformational and thermodynamic properties of apo A-1 of human plasma high density lipoproteins.
1976 • 99 citations
The Primary Structure of High Density Apolipoprotein-Glutamine-I
1974 • 99 citations
Fat transport and lymph and plasma lipoprotein biosynthesis by isolated intestine
1972 • 99 citations
Studies on the Protein Defect in Tangier Disease
1972 • 99 citations
Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma
1978 • 97 citations
Cross-linking studies of the self-association properties of apo-A-I and apo-A-II from human high density lipoprotein.
1978 • 96 citations
A Molecular Model of High Density Lipoproteins
1974 • 95 citations
Solubilisation of phospholipid membranes by human plasma high density lipoproteins
1977 • 95 citations
NMR studies of pig low- and high-density serum lipoproteins
1975 • 94 citations
Lipid-Protein Interactions in High Density Lipoproteins
1974 • 92 citations
Extrahepatic synthesis of lipoproteins of plasma and chyle: role of the intestine.
1966 • 90 citations
Effect of exercise on lipoprotein lipase activity in rat heart and skeletal muscle
1975 • 90 citations
13 C Nuclear Magnetic Resonance Spectroscopic Evidence for Hydrophobic Lipid-Protein Interactions in Human High Density Lipoproteins
1974 • 90 citations
Interaction of Apoprotein from Porcine High-Density Lipoprotein with Dimyristoyl Lecithin. 1. The Structure of the Complexes
1976 • 89 citations
The enhancement of alimentary lipemia by ethanol in man.
1970 • 89 citations
The kinetic characteristics of inhibition of hepatic cholesterogenesis by lipoproteins of intestinal origin
1975 • 89 citations
CHOLESTEROL METABOLISM IN THE MACROPHAGE
1971 • 88 citations
PROLONGED VENTILATION WITH CYCLATOR
1963 • 87 citations
CHOLESTEROL METABOLISM IN THE MACROPHAGE
1971 • 87 citations
The Molecular Properties of ApoA-I from Human High Density Lipoprotein
1974 • 86 citations
Liquid crystals in living and dying systems
1977 • 86 citations
Mechanism of induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase in human leukocytes.
1977 • 86 citations
Structure of human serum lipoproteins in solution
1976 • 83 citations
Interaction of Apoprotein from Porcine High-Density Lipoprotein with Dimyristoyl Lecithin. 2. Nature of Lipid-Protein Interaction
1976 • 82 citations
The Interaction of Apolipoprotein-Serine with Phosphatidylcholine
1974 • 80 citations
Combination of Delipidized High Density Lipoprotein with Lipids
1967 • 80 citations
Interaction between unilamellar egg yolk lecithin vesicles and human high density lipoprotein
1979 • 79 citations
Physical properties of isolated complexes of human and bovine A-I apolipoproteins with L-alpha-dimyristoyl phosphatidylcholine.
1977 • 79 citations
Reassembly in vitro of a serum high-density lipoprotein
1970 • 78 citations
The in vivo transformation of phospholipid vesicles to a particle resembling HDL in the rat
1976 • 77 citations
Activation of Lipoprotein Lipase by Apolipoprotein Glutamic Acid
1973 • 76 citations
Small‐angle X‐ray scattering of human serum high‐density lipoproteins
1972 • 75 citations
Cholesterol ester accumulation in cultured aortic smooth muscle cells
1977 • 75 citations
STUDIES OF THE METABOLISM OF RADIOIODINATED HUMAN SERUM ALPHA LIPOPROTEIN IN NORMAL AND HYPERLIPIDEMIC SUBJECTS.
1964 • 71 citations
Retention of lipolytic products in chylomicrons incubated with lipoprotein lipase: electron microscope study
1976 • 69 citations
REDUCED HIGH-DENSITY LIPOPROTEIN IN WOMEN AGED 40-41 USING ORAL CONTRACEPTIVES
1978 • 69 citations
Interaction of plasma high density lipoproteins with dimyristoyllecithin multilamellar liposomes
1978 • 68 citations
Mechanism of alcohol-induced hypertriglyceridemia.
1965 • 68 citations
The self-association of the apo-Gln-I and apo-Gln-II polypeptides of human high density serum lipoproteins.
1975 • 67 citations
Role of apolipoprotein A-I in the structure of human serum high density lipoproteins. Reconstitution studies.
1977 • 67 citations
Human High Density Lipoprotein, Apolipoprotein Glutamine II
1973 • 67 citations
Thermal behavior of human plasma high density lipoprotein
1977 • 66 citations
Parameters of the three-pool model of the turnover of plasma cholesterol in normal and hyperlipidemic humans.
1976 • 66 citations
Concentration of lipoproteins containing apolipoprotein B in human peripheral lymph
1977 • 66 citations
Amphipathic helixes and plasma lipoproteins: A computer study
1977 • 65 citations
Glutamine synthetase and control of nitrogen fixation in Rhizobium
1977 • 65 citations
EFFECTS OF LIPOPROTEIN LIPASE ON THE STRUCTURE OF CHYLOMICRONS
1973 • 64 citations
The Interaction of Polypeptide Components of Human High Density Lipoprotein with Sodium Dodecyl Sulfate
1974 • 61 citations
Deposition and mobilization of cholesterol ester in cultured human skin fibroblasts
1976 • 58 citations
Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured swine aortic smooth muscle cells by plasma lipoproteins
1975 • 58 citations
Apoprotein stability and lipid-protein interactions in human plasma high density lipoproteins.
1975 • 58 citations
Characterization of the lipoproteins of atherosclerotic swine.
1977 • 57 citations
Molecular weight and subunit structure of human serum high density lipoprotein after chemical modification by succinic anhydride
1968 • 56 citations
Studies on the structure of lipoprotein a of human high density lipoprotein HDL3: The spherically averaged electron density distribution
1973 • 56 citations
Failure of Complete Bile Diversion and Oral Bile Acid Therapy in the Treatment of Homozygous Familial Hypercholesterolemia
1977 • 56 citations
Apolipoproteins in rat serum and renal lymph.
1976 • 55 citations
Low density and high density lipoprotein turnover following portacaval shunt in swine
1976 • 55 citations
Biologically active low density lipoprotein in human peripheral lymph.
1978 • 54 citations
Interaction of cholesterol, phospholipid and apoprotein in high density lipoprotein recombinants
1978 • 54 citations
Kinetic study of the action of snake venom phospholipase A2 on human serum high density lipoprotein 3.
1976 • 53 citations
Interaction of cholesterol ester and triglyceride in human plasma very low density lipoprotein
1977 • 53 citations
Effect of cholesterol on the formation of micellar complexes between bovine A-I apolipoprotein and L-alpha-dimyristoylphosphatidylcholine
1978 • 53 citations
Metabolism of free fatty acids and chylomicron triglycerides during exercise in rats
1967 • 52 citations
The thermodynamics of the self-association of the reduced and carboxymethylated form of apoA-II from the human high density lipoprotein complex
1976 • 51 citations
The requirement for lipid fluidity in the formation and structure of lipoproteins: Thermotropic analysis of apolipoprotein-alanine binding to dimyristoyl phosphatidylcholine
1974 • 51 citations
Tangier Disease
1978 • 50 citations
Partial characterization of serum lipoproteins in the density interval 1.04–1.06 g/ml
1970 • 49 citations
Conformational stability of the polypeptide components of human high density serum lipoprotein.
1976 • 49 citations
Isolation and characterization of two threonine-poor apolipoproteins of human plasma high density lipoproteins
1978 • 48 citations
On the polypeptide composition of an abnormal high density lipoprotein (LP‐E) occurring in LCAT‐deficient plasma
1974 • 48 citations
Blood Lipids in Man—A Brief Review
1967 • 47 citations
Interaction of human and bovine A-1 apolipoproteins with L-alpha-dimyristoyl phosphadicylcholine and L-alpha-myristoyl lysophosphatidylcholine.
1977 • 46 citations
Structure of the major complex formed by interaction of phosphatidylcholine bilamellar vesicles and apolipoprotein-alanine (APO-C-III)
1974 • 46 citations
Self-association of apo-C-I from the human high density lipoprotein complex.
1977 • 44 citations
Removal of cholesterol from fibroblasts and smooth muscle cells in culture in the presence and absence of cholesterol esterification in the medium
1978 • 44 citations
CLOFIBRATE INCREASES LIPOPROTEIN-LIPASE ACTIVITY IN ADIPOSE TISSUE OF HYPERTRIGLYCERIDÆMIC PATIENTS
1977 • 42 citations
The Storage Lipids in Tangier Disease
1977 • 41 citations
Structure of an apolipoprotein-phospholipid complex: ApoC-III induced changes in the physical properties of dimyristoylphosphatidylcholine
1976 • 39 citations
Rate constants for the uptake of cholesterol from various intestinal and serum lipoprotein fractions by the liver of the rat in vivo
1977 • 38 citations
The solid phase synthesis of a protein activator for lecithin-cholesterol acyltransferase corresponding to human plasma apoC-I.
1976 • 36 citations
X‐ray small angle scattering of human plasma high density lipoprotein LpA from HDL2: Application of a new evaluation method
1974 • 36 citations
Catabolism of canine apolipoprotein A-I: purification, catabolic rate, organs of catabolism, and the liver subcellular catabolic site.
1976 • 36 citations
Incorporation of cholesterol into high density lipoprotein recombinants
1978 • 34 citations
Studies on human serum high-density lipoproteins. Self-association of human serum apolipoprotein A-II in aqueous solutions
1976 • 33 citations
The molecular behavior of apoA-I in human high density lipoproteins.
1975 • 33 citations
Study of the lipid binding characteristics of the apolipoproteins from human high density lipoprotein
1976 • 32 citations
The molar ratio of the two major polypeptide components of human high density lipoprotein.
1976 • 32 citations
On the temperature dependence of the conformation of human serum high density lipoprotein
1969 • 32 citations
High Density Lipoproteins in Cholestasis
1974 • 32 citations
Molecular dynamics of lipids in human plasma high density lipoproteins. A high field 13C NMR study.
1978 • 31 citations
Synthesis of plasma lipoproteins by the isolated perfused liver from the fasted and fed pig.
1977 • 29 citations
Structural organization of the lipoprotein HDLc from atherosclerotic swine. Structural features relating the particle surface and core
1978 • 29 citations
Liver and Bile
1932 • 29 citations
Degradation products from human serum high density lipoproteins following dehydration by rotary evaporation and solubilization
1972 • 29 citations
Lipoproteins of Synovial Fluid as Studied by Analytical Ultracentrifugation *
1964 • 29 citations
The structure of a high density lipoprotein (HDL 3 ) from porcine plasma
1974 • 28 citations
Chemical Proof of Lipid-Protein Interactions by Crosslinking Photosensitive Lipids to Apoproteins. Intermolecular Cross-Linkage between High-Density Apolipoprotein A-I and Lecithins and Sphingomyelins
1977 • 27 citations
Lipid binding protein (apolipoprotein A‐I) contamination of high grade commercial albumins
1979 • 27 citations
High density lipoprotein and low density lipoprotein catabolism by human liver and parenchymal and non-parenchymal cells from rat liver
1977 • 23 citations
Studies on the protein moiety of serum high density lipoprotein from patients with familial lecithin: cholesterol acyltransferase deficiency
1972 • 22 citations
Contrasting Effects on Plasma Lipoproteins of Intravenous Versus Oral Administration of a Triglyceride‐Phospholipid Emulsion
1975 • 21 citations
Immunochemical heterogeneity of human high densiy serum lipoproteins
1971 • 20 citations
Electron microscopy of negatively stained and freeze-etched high density lipoprotein-3 from human serum.
1977 • 18 citations
Interaction of apoliprotein C-III with phosphatidylcholine vesicles. Dependence of aproprotein-phospholipid complex formation on vesicle structure
1977 • 18 citations
Human High Density Apolipoprotein A-I-Lysolecithin-Lecithin and Sphingomyelin Complexes. A Method for High Yield Recombinations to Lipoprotein Complexes of Reproducible Stoichiometry
1976 • 17 citations
Location of aromatic amino acid residues in bovine serum high-density lipoprotein
1973 • 17 citations
Fluorescence polarization studies of human and rhesus A-I apolipoproteins and their complexes with phosphatidylcholine
1977 • 8 citations
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