The elusive nuclear matrix

DNA TOPOISOMERASES

1985 • 1,524 citations

Organization of the higher-order chromatin loop: specific DNA attachment sites on nuclear scaffold

1984 • 1,088 citations

Identification of a nuclear protein matrix

1974 • 1,016 citations

The structure of an oligo(dA)·oligo(dT) tract and its biological implications

1987 • 975 citations

The nuclear lamina is a meshwork of intermediate-type filaments

1986 • 957 citations

Chromosomal loop anchorage of the kappa immunoglobulin gene occurs next to the enhancer in a region containing topoisomerase II sites

1986 • 922 citations

Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins

1986 • 836 citations

A position-effect assay for boundaries of higher order chromosomal domains

1991 • 616 citations

Cohabitation of scaffold binding regions with upstream/enhancer elements of three developmentally regulated genes of D. melanogaster

1986 • 587 citations

Glycoproteins: Isolation from Cell Membranes with Lithium Diiodosalicylate

1971 • 543 citations

Nuclear Protein Matrix: Association with Newly Synthesized DNA

1975 • 487 citations

Three-dimensional architecture of a polytene nucleus

1983 • 453 citations

Topoisomerase II: A specific marker for cell proliferation.

1986 • 434 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

Binding of an antitumor drug to DNA

1985 • 423 citations

Transcription-dependent colocalization of the U1, U2, U4/U6, and U5 snRNPs in coiled bodies

1992 • 402 citations

Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the drosophila genome

1982 • 362 citations

THE ROLE OF THE NUCLEAR MATRIX IN THE ORGANIZATION AND FUNCTION OF DNA

1986 • 360 citations

The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells

1982 • 356 citations

The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotes

1975 • 341 citations

Preferential, cooperative binding of DNA topoisomerase II to scaffold-associated regions.

1989 • 317 citations

A mammalian high mobility group protein recognizes any stretch of six A.T base pairs in duplex DNA.

1986 • 313 citations

The organisation of chromatin loops: characterization of a scaffold attachment site

1986 • 308 citations

Transcription occurs at a nucleoskeleton.

1985 • 303 citations

Statistical distributions of nucleosomes: nonrandom locations by a stochastic mechanism

1988 • 291 citations

Tissue specific and position independent expression of the complete gene domain for chicken lysozyme in transgenic mice.

1990 • 289 citations

Identification of a novel nuclear domain.

1991 • 285 citations

Localization of RAP1 and topoisomerase II in nuclei and meiotic chromosomes of yeast

1992 • 280 citations

The matrix attachment regions of the chicken lysozyme gene co-map with the boundaries of the chromatin domain.

1988 • 280 citations

Considerations in the isolation of rat liver nuclear matrix, nuclear envelope, and pore complex lamina

1981 • 271 citations

Studies on the interaction of the human c-myc protein with cell nuclei: p62c-myc as a member of a discrete subset of nuclear proteins

1985 • 265 citations

Electrostatic mechanism of chromatin folding

1990 • 259 citations

Translocation of a specific premessenger ribonucleoprotein particle through the nuclear pore studied with electron microscope tomography

1992 • 254 citations

Chromosomal ARS and CEN elements bind specifically to the yeast nuclear scaffold

1988 • 251 citations

The 87A7 chromomere

1985 • 249 citations

The size of chromatin loops in HeLa cells.

1990 • 246 citations

Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors.

1991 • 239 citations

Drosophilatopoisomerase II double-strand DNA cleavage: analysis of DNA sequence homology at the cleavage site

1985 • 239 citations

NuMA: an unusually long coiled-coil related protein in the mammalian nucleus.

1992 • 231 citations

Nuclear scaffold attachment sites in the human globin gene complexes.

1988 • 225 citations

Physicochemical studies of the folding of the 100 Å nucleosome filament into the 300 Å filament

1986 • 224 citations

The nuclear matrix: Structure and composition

1988 • 220 citations

A matrix/scaffold attachment region binding protein: Identification, purification, and mode of binding

1991 • 205 citations

Chromatin differences between active and inactive X chromosomes revealed by genomic footprinting of permeabilized cells using DNase I and ligation-mediated PCR.

1991 • 195 citations

Replication occurs at discrete foci spaced throughout nuclei replicating in vitro

1989 • 192 citations

In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics.

1992 • 181 citations

Characteristic folding pattern of polytene chromosomes in Drosophila salivary gland nuclei

1984 • 181 citations

Highly preferential nucleation of histone H1 assembly on scaffold-associated regions

1989 • 165 citations

A general method for preparing chromatin containing intact DNA.

1985 • 161 citations

Interaction of DNA with nuclear scaffolds in vitro

1988 • 143 citations

The nucleoskeleton: Artefact, passive framework or active site?

1988 • 143 citations

Solution structure of the chromomycin-DNA complex

1989 • 138 citations

Specific inhibition of DNA Binding to nuclear scaffolds and histone H1 by distamycin

1989 • 137 citations

Nuclear scaffolds and scaffold-attachment regions in higher plants.

1991 • 134 citations

Three-dimensional organization of Drosophila melanogaster interphase nuclei. I. Tissue-specific aspects of polytene nuclear architecture.

1987 • 122 citations

Analysis of the ftz upstream element: germ layer-specific enhancers are independently autoregulated.

1990 • 118 citations

Intracellular localization and metabolism of DNA polymerase α in human cells visualized with monoclonal antibody

1984 • 115 citations

Lactate dehydrogenase and glyceraldehyde‐phosphate dehydrogenase are single‐stranded DNA‐binding proteins that affect the DNA‐polymerase‐α–primase complex

1986 • 110 citations

Drosophila scaffold-attached regions bind nuclear scaffolds and can function as ARS elements in both budding and fission yeasts.

1990 • 89 citations

Distamycin-induced inhibition of homeodomain-DNA complexes.

1992 • 88 citations

Genes and loops in 320,000 base-pairs of the Drosophila melanogaster chromosome

1986 • 81 citations

Mapping of Structural and Transcription-Related Matrix Attachment Sites in the α-Globin Gene Domain of Avian Erythroblasts and Erythrocytes

1990 • 76 citations

DNA replication occurs at discrete sites in pseudonuclei assembled from purified DNA in vitro

1991 • 76 citations

Chromatin structure of the chicken lysozyme gene domain as determined by chromatin fractionation and micrococcal nuclease digestion

1986 • 74 citations

Identification of a nucleic acid helix-destabilizing protein from rat liver as lactate dehydrogenase-5.

1985 • 68 citations

Nuclear scaffold attachment stimulates, but is not essential for ARS activity in Saccharomyces cerevisiae: analysis of the Drosophila ftz SAR.

1990 • 65 citations

Compartmentalization within the nucleus: discovery of a novel subnuclear region.

1991 • 64 citations

Protein-depleted chromosomes

1981 • 62 citations

Protein-depleted chromosomes

1981 • 61 citations

Studies of an 800-kilobase DNA stretch of the Drosophila X chromosome: comapping of a subclass of scaffold-attached regions with sequences able to replicate autonomously in Saccharomyces cerevisiae.

1990 • 60 citations

Attachment of DNA to the nucleoskeleton of HeLa cells examined using physiological conditions

1990 • 58 citations

Active RNA polymerase I is fixed within the nucleus of HeLa cells.

1990 • 58 citations

Mapping of structural and transcription-related matrix attachment sites in the alpha-globin gene domain of avian erythroblasts and erythrocytes.

1990 • 53 citations

Nuclear matrix and transcriptional activity of the mouse α-globin gene

1984 • 52 citations

Nuclear skeleton, DNA domains and control of replication and transcription

1991 • 45 citations

Identification of the binding sites for potential regulatory proteins in the upstream enhancer element of theDrosophila fushi tarazugene

1988 • 30 citations

An ectopic copy of the Drosophila ftz associated SAR neither reorganizes local chromatin structure nor hinders elution of a chromatin fragment from isolated nuclei.

1991 • 25 citations

Restriction enzymes have limited access to DNA sequences in Drosophila chromosomes.

1990 • 23 citations

Immunoreactive helix-destabilizing protein localized in transcriptionally active regions of Drosophila polytene chromosomes.

1980 • 16 citations

Restriction enzymes permit quantitative determination of defined chromatin structures within the chromosome

1991 • 15 citations