Hypoxia upregulates the expression of angiopoietin‐like‐4 in human articular chondrocytes: Role of angiopoietin‐like‐4 in the expression of matrix metalloproteinases and cartilage degradation

Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis

1996 • 2,844 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene

2000 • 540 citations

Hypoxia Induces Vascular Endothelial Growth Factor in Cultured Human Endothelial Cells

1995 • 487 citations

Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans

1999 • 463 citations

The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity

2005 • 420 citations

Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation

2000 • 388 citations

Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase

2002 • 356 citations

Oxygen tension in synovial fluids

1970 • 328 citations

Angiopoietin-Like 4 Is a Proangiogenic Factor Produced during Ischemia and in Conventional Renal Cell Carcinoma

2003 • 323 citations

The Direct Peroxisome Proliferator-activated Receptor Target Fasting-induced Adipose Factor (FIAF/PGAR/ANGPTL4) Is Present in Blood Plasma as a Truncated Protein That Is Increased by Fenofibrate Treatment

2004 • 263 citations

Oxygen Tension in Zones of the Epiphyseal Plate, the Metaphysis and Diaphysis

1971 • 242 citations

Expression of vascular endothelial growth factor in synovial fibroblasts is induced by hypoxia and interleukin 1beta.

1997 • 226 citations

Biological characterization of angiopoietin‐3 and angiopoietin‐4

2004 • 169 citations

Oligomerization and Regulated Proteolytic Processing of Angiopoietin-like Protein 4

2004 • 155 citations

Hypoxia Up-regulates Expression of Peroxisome Proliferator-activated Receptor γ Angiopoietin-related Gene (PGAR) in Cardiomyocytes: Role of Hypoxia Inducible Factor 1α

2002 • 137 citations

Catabolic stress induces expression of hypoxia-inducible factor (HIF)-1 alpha in articular chondrocytes: involvement of HIF-1 alpha in the pathogenesis of osteoarthritis.

2005 • 121 citations

Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart

2005 • 113 citations

Angiopoietin-related growth factor (AGF) promotes angiogenesis

2004 • 108 citations

Angiopoietin-like-4 is a potential angiogenic mediator in arthritis

2005 • 76 citations

Effect of hypoxia and reoxygenation on gene expression and response to interleukin‐1 in cultured articular chondrocytes

2004 • 59 citations

Distinct signaling pathways are involved in hypoxia- and IL-1-induced VEGF expression in human articular chondrocytes

2006 • 47 citations

Influence of hypoxia on the expression of matrix metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 in rheumatoid synovial fibroblasts.

2003 • 37 citations

Hypoxia-induced increase of matrix metalloproteinase-1 synthesis is not restored by reoxygenation in a three-dimensional culture of human dermal fibroblasts

2003 • 22 citations

Entropy and Synovial Pathology

1959 • 3 citations