Clinical Pharmacokinetics of Sedatives in Neonates

Goodman & Gilman's The Pharmacological Basis of Therapeutics

1985 • 7,054 citations

Pain and Its Effects in the Human Neonate and Fetus

1987 • 1,572 citations

Midazolam: pharmacology and uses.

1985 • 900 citations

Halothane–Morphine Compared with High-Dose Sufentanil for Anesthesia and Postoperative Analgesia in Neonatal Cardiac Surgery

1992 • 846 citations

RANDOMISED TRIAL OF FENTANYL ANAESTHESIA IN PRETERM BABIES UNDERGOING SURGERY: EFFECTS ON THE STRESS RESPONSE

1987 • 755 citations

Propofol. An update on its clinical use.

1994 • 594 citations

Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports.

1992 • 572 citations

Assessment of children's distress during painful medical procedures.

1983 • 494 citations

Morphine and metabolite behavior after different routes of morphine administration: Demonstration of the importance of the active metabolite morphine-6-glucuronide

1990 • 446 citations

Clinical Pharmacokinetics of Fentanyl and its Newer Derivatives

1983 • 375 citations

Reduction in Intraventricular Hemorrhage by Elimination of Fluctuating Cerebral Blood-Flow Velocity in Preterm Infants with Respiratory Distress Syndrome

1985 • 363 citations

The Pharmacokinetics of Propofol in Children Using Three Different Data Analysis Approaches

1994 • 320 citations

The Gasping Syndrome and Benzyl Alcohol Poisoning

1982 • 255 citations

Prospective study on the occurrence of withdrawal in critically ill children who receive fentanyl by continuous infusion

1994 • 254 citations

Pharmacokinetics of Fentanyl in Neonates

1986 • 243 citations

Morphine Pharmacokinetics in Early Infancy

1987 • 242 citations

Respiratory sensitivity of the newborn infant to meperidine and morphine

1965 • 225 citations

Tolerance and Dependence in Neonates Sedated with Fentanyl during Extracorporeal Membrane Oxygenation

1990 • 221 citations

Blunting of Stress Responses in the Pulmonary Circulation of Infants by Fentanyl

1985 • 211 citations

Principles of Drug Biodisposition in the Neonate

1988 • 200 citations

Pharmacokinetics and Bioavailability of Intravenous, Intramuscular, and Oral Lorazepam in Humans

1979 • 197 citations

Postoperative morphine infusion in newborn infants: Assessment of disposition characteristics and safety

1985 • 184 citations

Principles of Drug Biodisposition in the Neonate

1988 • 180 citations

Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3-glucuronide

1991 • 178 citations

Pain Relief Can Reduce Hypoxemia in Distressed Neonates During Routine Treatment Procedures

1994 • 172 citations

Respiratory Effects of Intravenous Morphine Infusions in Neonates, Infants, and Children After Cardiac Surgery

1993 • 168 citations

Population pharmacokinetics of midazolam in neonates

1994 • 163 citations

Interaction of spontaneous respiration with artificial ventilation in preterm babies

1983 • 159 citations

Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies

1993 • 152 citations

Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion

1991 • 148 citations

Morphine metabolism in children.

1989 • 147 citations

The Maturation of Morphine Clearance and Metabolism

1992 • 146 citations

Reversible neurologic abnormalities associated with prolonged intravenous midazolam and fentanyl administration

1991 • 145 citations

Morphine infusion after pediatric cardiac surgery

1984 • 141 citations

Pharmacokinetic-pharmacodynamic relationships of morphine in neonates

1992 • 140 citations

Measurement of post-operative pain and narcotic administration in infants using a new clinical scoring system

1989 • 136 citations

Oral morphine in cancer patients: in vivo kinetics and in vitro hepatic glucuronidation.

1985 • 131 citations

Sufentanil Pharmacokinetics in Pediatric Cardiovascular Patients

1987 • 131 citations

Clinical experience with continuous intravenous sedation using midazolam and fentanyl in the paediatric intensive care unit

1991 • 128 citations

Pulmonary and Systemic Hemodynamic Responses to Fentanyl in Infants

1985 • 126 citations

Kinetics and dynamics of postoperative intravenous morphine in children

1988 • 125 citations

Pharmacokinetics of Fentanyl in Neonatal Humans and Lambs

1988 • 125 citations

Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies

1994 • 123 citations

Pharmacokinetics of a single dose of morphine in preterm infants during the first week of life

1990 • 123 citations

Diazepam elimination in premature and full term infants, and children

1973 • 116 citations

Placental transfer of diazepam and its disposition in the newborn

1975 • 116 citations

The Dose Response of Fentanyl in Neonatal Anesthesia

1987 • 113 citations

Clinical Pharmacology of the Perinatal Period and Early Infancy

1989 • 109 citations

Pharmacokinetics of midazolam during continuous infusion in critically ill neonates

1992 • 105 citations

Pharmacokinetics of midazolam in critically ill neonates

1990 • 103 citations

Pain in children aged 2–6 years: A new observational rating scale elaborated in a pediatric oncology unit — preliminary report

1987 • 103 citations

PHARAMACOKINETICS OF PROPOFOL IN YOUNG CHILDREN AFTER A SINGLE DOSE

1989 • 99 citations

Fentanyl Pharmacokinetics and Hemodynamic Effects in Preterm Infants during Ligation of Patent Ductus Arteriosus

1985 • 95 citations

Randomized Trial of Fentanyl Anesthesia in Preterm Babies Undergoing Surgery

1987 • 93 citations

A Comparison of Alfentanil Pharmacokinetics in Children and Adults

1987 • 90 citations

Face scales for the assessment of pediatric pain: A critical review.

1989 • 90 citations

PHARMACOKINETICS OF PROPOFOL IN CHILDREN

1990 • 90 citations

Age-Related Morphine Kinetics in Infants

1993 • 90 citations

Pharmacokinetics of morphine infusion in premature neonates.

1993 • 81 citations

Clinical Uses Of Fentanyl, Sufentanil, And Alfentanil

1991 • 74 citations

Changes in Sufentanil Pharmacokinetics Within the Neonatal Period

1988 • 72 citations

FENTANYL PHARMACOKINETICS IN THE PEDIATRIC POPULATION

1984 • 71 citations

METABOLISM OF LORAZEPAM

1976 • 70 citations

Morphine metabolism in neonates and infants.

1992 • 70 citations

ANALGESIA AND SEDATION IN INTENSIVE CARE

1989 • 69 citations

Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol.

1954 • 67 citations

Effects of Age on Plasma Protein Binding of Sufentanil

1990 • 67 citations

Pharmacokinetics of Alfentanil in Newborn Premature Infants and Older Children

1989 • 67 citations

Analgesia and anesthesia in neonates

1987 • 66 citations

Pharmacokinetics of lorazepam in critically ill neonates with seizures

1992 • 66 citations

Management of Pain in the Postoperative Neonate

1989 • 64 citations

Alfentanil pharmacokinetics in preterm infants.

1990 • 63 citations

Effects of Fentanyl on Baroreceptor Reflex Control of Heart Rate in Newborn Infants

1988 • 62 citations

Neurological sequelae in children after prolonged propofol infusion

1992 • 60 citations

Comparison of the Effect of Midazolam or Vecuronium on Blood Pressure and Cerebral Blood Flow Velocity in the Premature Newborn

1992 • 59 citations

Alfentanil-Induced Rigidity in Newborn Infants

1992 • 59 citations

Morphine metabolism in acutely ill preterm newborn infants

1992 • 58 citations

Naloxone dosage and route of administration for infants and children: Addendum to emergency drug doses for infants and children

1990 • 55 citations

Plasma concentration of diazepam and N-desmethyldiazepam in children after a single rectal or intramuscular dose of diazepam

1978 • 55 citations

PHARMACOKINETICS OF FLUMAZENIL AND MIDAZOLAM

1993 • 54 citations

Pharmacokinetics and pharmacodynamics of intravenous meperidine in neonates and infants

1992 • 54 citations

Placental transfer of pethidine and norpethidine and their pharmacokinetics in the newborn

1980 • 51 citations

Pain in the Newborn

1989 • 51 citations

Lorazepam in the Treatment of Refractory Neonatal Seizures

1991 • 51 citations

Clinical Pharmacokinetics of the Benzodiazepines

1985 • 48 citations

Influence of Gestational Age on Pharmacokinetics of Alfentanil in Neonates

1990 • 47 citations

Morphine kinetics after diamorphine infusion in premature neonates.

1991 • 46 citations

Analgesia and Sedation in Neonatal Intensive Care Using Fentanyl by Continuous Infusion

1991 • 46 citations

Morphine pharmacokinetics in premature and mature newborn infants

1994 • 44 citations

PLASMA CONCENTRATIONS OF DIAZEPAM AND N‐DESMETHYLDIAZEPAM IN NEWBORN INFANTS AFTER INTRAVENOUS, INTRAMUSCULAR, RECTAL AND ORAL ADMINISTRATION

1978 • 43 citations

Narcotic sedation stabilizes arterial blood pressure fluctuations in sick premature infants.

1991 • 43 citations

Chloral hydrate sedation in neonates and infants--clinical and pharmacologic considerations.

1989 • 43 citations

Lorazepam pharmacodynamics and pharmacokinetics in children

1989 • 39 citations

Morphine sulphation in children.

1990 • 37 citations

Decreased serum protein binding of diazepam and its major metabolite in the neonate during the first postnatal week relate to increased free fatty acid levels.

1984 • 36 citations

Direct Hyperbilirubinemia Associated With Chioral Hydrate Administration in the Newborn

1990 • 36 citations

Clinical Pharmacokinetics of Benzodiazipines

1994 • 32 citations

Differences in in vitro binding of diazepam and N-desmethyldiazepam to maternal and fetal plasma proteins at birth: Relation to free fatty acid concentration and other parameters

1983 • 31 citations

Various factors which affect the rate of development of tolerance and physical dependence to abused drugs.

1984 • 31 citations

Diazepam metabolism in human foetal and adult liver

1977 • 31 citations

The Use Of Flumazenil In A Neonate

1991 • 27 citations

Determination of chloral hydrate metabolism in adult and neonate biological fluids after single-dose administration

1990 • 27 citations

Ontogeny of the Benzodiazepine Receptor in Human Brain: Fluorographic, Immunochemical, and Reversible Binding Studies

1991 • 27 citations

The Disposition of Alfentanil in Neonates with Respiratory Distress

1991 • 25 citations

Lorazepam Toxicity in a Premature Infant

1993 • 25 citations

The Pharmacokinetics of Naloxone in the Premature Newborn

1987 • 22 citations

Sedative/Hypnotic Effects of Chloral Hydrate in the Neonate: Trichloroethanol or Parent Drug?

1992 • 18 citations

PHARMACOKINETICS OF FENTANYL FOR INFANTS AND ADULTS

1984 • 18 citations

Neurotoxicity of Lorazepam in a Premature Infant

1992 • 16 citations

Neurotoxicity of lorazepam in a premature infant.

1992 • 15 citations

Changes in sufentanil pharmacokinetics within the neonatal period.

1988 • 13 citations

American Academy of Pediatrics Committee on Drugs: Naloxone dosage and route of administration for infants and children: addendum to emergency drug doses for infants and children.

1990 • 12 citations

Fetal, neonatal and adult expression of benzodiazepine receptor subtypes in human visual cortex

1993 • 10 citations

Ventilatory management casebook. Chloral hydrate intoxication.

1994 • 7 citations

[Flumazenil: a useful antagonist in pediatrics].

1988 • 7 citations

[Effect of fentanyl on ventilation in a premature infant].

1993 • 4 citations

PLACENTAL TRANSFER OF DIAZEPAM AND ITS DISPOSITION IN THE NEWBORN

1976 • 3 citations

Chloral hydrate.

1992 • 1 citations

Deleted Work

1955 • 0 citations