The treatment of brain metastases in melanoma patients

Randomized Phase III Study of Temozolomide Versus Dacarbazine in the Treatment of Patients With Advanced Metastatic Malignant Melanoma

2000 • 1,252 citations

Temozolomide: a review of its discovery, chemical properties, pre-clinical development and clinical trials

1997 • 777 citations

Intracerebral metastases in solid-tumor patients: Natural history and results of treatment

1981 • 604 citations

Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma

1998 • 548 citations

Phase I trial of temozolomide (CCRG 81045: M&B 39831: NSC 362856)

1992 • 483 citations

Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.

1987 • 386 citations

Demographics of Brain Metastasis

1996 • 325 citations

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

1995 • 290 citations

Stereotactic radiosurgery for cerebral metastatic melanoma: factors affecting local disease control and survival

1998 • 265 citations

287 Management of brain metastases

2004 • 255 citations

Final report of the french multicenter phase II study of the nitrosourea fotemustine in 153 evaluable patients with disseminated malignant melanoma including patients with cerebral metastases

1990 • 243 citations

Absorption, metabolism, and excretion of 14C-temozolomide following oral administration to patients with advanced cancer.

1999 • 219 citations

The spectrum of neurological disease in patients with systemic cancer

1992 • 204 citations

Stereotactic radiosurgery for cerebral metastatic melanoma

1993 • 195 citations

Surgical treatment of brain metastases from melanoma: a retrospective study of 91 patients

2000 • 186 citations

Management of brain metastases

2016 • 171 citations

Cranial irradiation after surgical excision of brain metastases in melanoma patients

1996 • 151 citations

Temozolomide and whole brain irradiation in melanoma metastatic to the brain: a phase II trial of the Cytokine Working Group

2002 • 148 citations

Phase II Study of Temozolomide Plus Thalidomide for the Treatment of Metastatic Melanoma

2003 • 145 citations

Gamma Knife Radiosurgery for Malignant Melanoma Brain Metastases

2006 • 118 citations

Survival by radiation therapy oncology group recursive partitioning analysis class and treatment modality in patients with brain metastases from malignant melanoma

2002 • 117 citations

Palliative radiotherapy for metastatic malignant melanoma: Brain metastases, bone metastases, and spinal cord compression

1988 • 114 citations

The current causes of death in patients with malignant melanoma

1978 • 99 citations

Clinical presentation, natural history and prognostic factors in advanced malignant melanoma.

1979 • 91 citations

Radiosurgery without whole brain radiotherapy in melanoma brain metastases

1998 • 86 citations

Temozolomide in Combination With Docetaxel in Patients With Advanced Melanoma: A Phase II Study of the Hellenic Cooperative Oncology Group

2002 • 71 citations

Pharmacokinetics of temozolomide in association with fotemustine in malignant melanoma and malignant glioma patients: comparison of oral, intravenous, and hepatic intra-arterial administration

1998 • 71 citations

Fotemustine in the Treatment of Brain Primary Tumors and Metastases

1994 • 67 citations

Palliative therapy of melanoma patients with fotemustine. Inverse relationship between tumour load and treatment effectiveness. A multicentre phase II trial of the EORTC-Melanoma Cooperative Group (MCG)

1995 • 62 citations

Pharmacokinetic assessment of novel anti-cancer drugs using spectral analysis and positron emission tomography: A feasibility study

1998 • 57 citations

Cerebral metastases of cutaneous melanoma

1997 • 55 citations

Response of intracranial melanoma metastases to stereotactic radiosurgery

1997 • 48 citations

Treatment of metastatic melanoma in the brain with temozolomide and thalidomide

2001 • 46 citations

Neck Dissection: Past, Present, Future

2005 • 42 citations

Phase II trial of fotemustine in patients with metastatic malignant melanoma

1994 • 33 citations

Management of Brain Metastases

2020 • 26 citations

Brain metastases

1999 • 22 citations

A pilot study of temozolomide as first line therapy of central nervous system metastases from malignant melanoma

2000 • 3 citations