Effects of D3.49A, R3.50A, and A6.34E mutations on ligand binding and activation of the cannabinoid-2 (CB2) receptor
Data up to Jan 2025
Total Citations Per Year
Abstract
References (36)
Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction
1973 • 12,522 citations
High-efficiency transformation of mammalian cells by plasmid DNA.
1987 • 5,377 citations
Molecular characterization of a peripheral receptor for cannabinoids
1993 • 4,950 citations
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
1990 • 4,933 citations
[19] Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G protein-coupled receptors
1995 • 2,811 citations
Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish
1964 • 2,296 citations
Pharmacology of cannabinoid CB1 and CB2 receptors
1997 • 1,448 citations
STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS
1994 • 1,070 citations
Methods in Neurosciences
1992 • 622 citations
Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.
1992 • 587 citations
G Protein-coupled Receptors
1998 • 570 citations
Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs.
1986 • 446 citations
Endocannabinoids
1998 • 416 citations
Agonists induce conformational changes in transmembrane domains III and VI of the beta 2 adrenoceptor
1997 • 378 citations
Constitutively active mutants of the alpha 1B-adrenergic receptor: role of highly conserved polar amino acids in receptor activation.
1996 • 377 citations
‘Endocannabinoids’ and other fatty acid derivatives with cannabimimetic properties: biochemistry and possible physiopathological relevance
1998 • 317 citations
Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.
1992 • 266 citations
Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat
1997 • 249 citations
Mutation of a Highly Conserved Aspartic Acid in the β2Adrenergic Receptor: Constitutive Activation, Structural Instability, and Conformational Rearrangement of Transmembrane Segment 6
1999 • 203 citations
Mutagenesis of the beta2-Adrenergic Receptor: How Structure Elucidates Function
1992 • 192 citations
Molecular architecture of G protein-coupled receptors
1996 • 178 citations
A common step for signal transduction in G protein-coupled receptors
1994 • 152 citations
Protein Kinase C Disrupts Cannabinoid Actions by Phosphorylation of the CB1 Cannabinoid Receptor
1998 • 150 citations
The Difference between the CB1 and CB2Cannabinoid Receptors at Position 5.46 Is Crucial for the Selectivity of WIN55212-2 for CB2
1999 • 117 citations
Construction of a 3D model of the cannabinoid cb1 receptor: Determination of helix ends and helix orientation
1995 • 115 citations
Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: implication for intracellular signalization cross-regulation.
1999 • 114 citations
Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation.
2000 • 112 citations
Cannabinoid receptor stimulation of guanosine-5′-O-(3-[35S]thio)triphosphate binding in rat brain membranes
1996 • 107 citations
SR 144528, an antagonist for the peripheral cannabinoid receptor that behaves as an inverse agonist.
1999 • 102 citations
The Role of the Aspartate-Arginine-Tyrosine Triad in the m1 Muscarinic Receptor: Mutations of Aspartate 122 and Tyrosine 124 Decrease Receptor Expression but Do Not Abolish Signaling
1997 • 85 citations
The CB1Cannabinoid Receptor in the Brain
1998 • 83 citations
An arginine residue conserved in most G protein-coupled receptors is essential for the function of the m1 muscarinic receptor.
1994 • 74 citations
Molecular probes for the cannabinoid receptors
2000 • 73 citations
Role of the highly conserved Asp‐Arg‐Tyr motif in signal transduction of the CB2 cannabinoid receptor
2000 • 45 citations
Inverse agonistic effect of ICI-174,864 on the cloned delta-opioid receptor: role of G protein and adenylyl cyclase activation.
1996 • 37 citations
Functional roles of the tyrosine within the NP(X)nY motif and the cysteines in the C‐terminal juxtamembrane region of the CB2 cannabinoid receptor
2001 • 27 citations