Evidence that glutamate is released from capsaicin-sensitive primary afferent fibers in rats: study with on-line continuous monitoring of glutamate

Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons.

1991 • 1,760 citations

Hyperalgesia Mediated by Spinal Glutamate or Substance P Receptor Blocked by Spinal Cyclooxygenase Inhibition

1992 • 725 citations

Glutamate and substance P coexist in primary afferent terminals in the superficial laminae of spinal cord.

1988 • 580 citations

Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin

1992 • 572 citations

The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury

1992 • 564 citations

Extracellular Amino Acid Concentrations in the Dorsal Spinal Cord of Freely Moving Rats Following Veratridine and Nociceptive Stimulation

1988 • 396 citations

Fluorometric determination of aspartate, glutamate, and γ-aminobutyrate in nerve tissue using enzymic method

1966 • 388 citations

Substance P release from spinal cord slices by capsaicin

1979 • 376 citations

Coexistence of glutamate and substance P in dorsal root ganglion neurons of the rat and monkey

1988 • 363 citations

Quantitative autoradiographic distribution of L-[3H]glutamate-binding sites in rat central nervous system

1984 • 353 citations

Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn

1985 • 309 citations

The intrathecal administration of excitatory amino acid receptor antagonists selectively attenuated carrageenan-induced behavioral hyperalgesia in rats

1992 • 242 citations

Tachykinins and calcitonin gene-related peptide enhance release of endogenous glutamate and aspartate from the rat spinal dorsal horn slice

1990 • 229 citations

Capsaicin-evoked release of substance P from primary sensory neurons

1979 • 227 citations

Ultrastructural visualization of glutamate and aspartate immunoreactivities in the rat dorsal horn, with special reference to the co-localization of glutamate, substance P and calcitonin-gene related peptide

1991 • 165 citations

Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons

1981 • 161 citations

The effect of capsaicin on voltage‐gated calcium currents and calcium signals in cultured dorsal root ganglion cells

1990 • 100 citations

Capsazepine, a novel capsaicin antagonist, selectively antagonises the effects of capsaicin in the mouse spinal cord in vitro

1991 • 90 citations

Quantitative autoradiographic analysis of excitatory amino acid receptors in the cat spinal cord

1991 • 62 citations

Capsaicin-induced release of calcitonin gene-related peptide from dorsal horn slices is enhanced in adjuvant arthritic rats

1989 • 62 citations

The non-NMDA antagonist CNQX prevents release of amino acids into the rat spinal cord dorsal horn evoked by sciatic nerve stimulation

1992 • 61 citations

Localisation of glutamate receptor binding sites and mRNAS to the dorsal horn of the rat spinal cord

1993 • 59 citations

Detection of capsaicin-evoked release of glutamate from spinal dorsal horn slices of rat with on-line monitoring system

1993 • 57 citations

Identification by high-performance liquid chromatography of immunoreactive substance P released from isolated rat spinal cord

1980 • 48 citations

Exposure to calcium-free medium protects sensory fibers by capsaicin desensitization

1987 • 45 citations

NMDA receptor antagonist blocks the facilitation of the tail flick reflex in the rat induced by intrathecal administration of substance P and by noxious cutaneous stimulation

1991 • 44 citations

Behavioral sensitization to kainic acid and quisqualic acid in mice: comparison to NMDA and substance P responses

1991 • 36 citations

Capsaicin-like effect of (6)-shogaol on substance P-containing primary afferents of rats: A possible mechanism of its analgesic action

1992 • 34 citations

Desensitization of capsaicin-evoked neuropeptide release — Influence of Ca2+ and temperature

1990 • 25 citations

Serotonin, but neither noradrenaline nor GABA, inhibits capsaicin-evoked release of immunoreactive somatostatin from slices of rat spinal cord

1991 • 22 citations

Pharmacological Evidence for Involvement of Excitatory Amino Acids in Aversive Responses Induced by Intrathecal Substance P in Rats.

1993 • 19 citations

Capsaicin Does Not Change Tissue Levels of Glutamic Acid, Its Uptake, or Release in the Rat Spinal Cord

1982 • 17 citations

Calcium and capsaicin- induced substance P release from peripheral terminals of primary sensory neurons

1988 • 16 citations

Capsaicin inhibits whereas rhizotomy potentiates substance P-induced release of excitatory amino acids in the rat spinal cord in vivo

1993 • 14 citations

Depolarization-evoked release of glutamate, aspartate and γ-aminobutyric acid from rat dorsal spinal cord does not originate from capsaicin-sensitive neurons

1991 • 12 citations

Release of putative peptide and amino acid nociceptive transmitters from rat spinal cord in vitro

1990 • 3 citations