Rational Design and Synthesis of a Novel Anti-leukemic Agent Targeting Bruton′s Tyrosine Kinase (BTK), LFM-A13 [α-Cyano-β-Hydroxy-β-Methyl-N-(2,5-Dibromophenyl)Propenamide]

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Crystal structure of the Src family tyrosine kinase Hck

1997 • 1,165 citations

Apoptosis and Programmed Cell Death in Immunity

1992 • 1,105 citations

Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors

1997 • 1,098 citations

The development of a simple empirical scoring function to estimate the binding constant for a protein-ligand complex of known three-dimensional structure

1994 • 975 citations

Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

1997 • 929 citations

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID Mice

1993 • 868 citations

A License to Kill

1996 • 649 citations

Regulators of cell death

1995 • 647 citations

A fast algorithm for rendering space-filling molecule pictures

1988 • 616 citations

LUDI: rule-based automatic design of new substituents for enzyme inhibitor leads

1992 • 450 citations

2.2 Å refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor

1993 • 356 citations

CHAIN — A crystallographic modeling program

1988 • 341 citations

Impaired expansion of mouse B cell progenitors lacking Btk

1995 • 314 citations

Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases

1995 • 279 citations

Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.

1994 • 240 citations

Molecular mechanisms in B cell antigen receptor signaling

1997 • 194 citations

Apoptosis by a cytosolic extract from Fas-activated cells.

1995 • 167 citations

BTK as a Mediator of Radiation-Induced Apoptosis in DT-40 Lymphoma B Cells

1996 • 166 citations

Src Family Protein Tyrosine Kinases Induce Autoactivation of Bruton's Tyrosine Kinase

1995 • 151 citations

Bruton's Tyrosine Kinase as an Inhibitor of the Fas/CD95 Death-inducing Signaling Complex

1999 • 124 citations

An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis.

1996 • 117 citations

Bruton's Tyrosine Kinase is a Key Regulator in B‐Cell Development

1994 • 107 citations

Regulation of Btk by Src Family Tyrosine Kinases

1996 • 106 citations

Synthesis, Structure−Activity Relationships, and Pharmacokinetic Properties of Dihydroorotate Dehydrogenase Inhibitors: 2-Cyano-3-cyclopropyl-3-hydroxy- N-[3‘-methyl-4‘-(trifluoromethyl)phenyl]propenamide and Related Compounds

1996 • 90 citations

BTKbase: a database of XLA-causing mutations

1995 • 90 citations

Bruton’s tyrosine kinase (BTK) as a dual-function regulator of apoptosis

1998 • 74 citations

Differentiation and cell death: lessons from the immune system

1994 • 57 citations

Role of Tyrosine Kinases in Induction of the c-junProto-oncogene in Irradiated B-lineage Lymphoid Cells

1998 • 53 citations

Synthesis and biological activity of a series of diaryl-substituted .alpha.-cyano-.beta.-hydroxypropenamides, a new class of anthelmintic agents

1991 • 23 citations

Reconstitution of the B Cell Antigen Receptor Signaling Components in COS Cells

1995 • 22 citations