The dhfrI trimethoprim resistance gene of Tn7 can be found at specific sites in other genetic surroundings

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Experiments in molecular genetics

1972 • 28,260 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Crystalline Dihydropteroylglutamic Acid

1960 • 461 citations

Nucleotide sequence of the E. coli gene coding for dihydrofolate reductase

1980 • 378 citations

Transposition of a deoxyribonucleic acid sequence encoding trimethoprim and streptomycin resistances from R483 to other replicons

1976 • 280 citations

Site-specific recombination promotes linkage between trimethoprim- and sulfonamide resistance genes. Sequence characterization of dhfrV and sulI and a recombination active locus of Tn21

1988 • 252 citations

Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.

1987 • 228 citations

Nucleotide sequence analysis of a gene encoding a streptomycin/spectinomycin adenyltransferase

1985 • 204 citations

Nucleotide sequence of the AAD(2′) aminoglycoside adenylyltransferase determinantaadB. Evolutionary relationship of this region with those surroundingaadAin R538-1 anddhfrllin R388

1986 • 164 citations

The nucleotide sequence of the mercuric resistance operons of plasmid R100 and transposon Tn501: further evidence for mer genes which enhance the activity of the mercuric ion detoxification system

1986 • 152 citations

Transposon Tn21 encodes a RecA-independent site-specific integration system

1988 • 126 citations

The region of the incN plasmid R46 coding for resistance to β-lactam antibiotics, streptomycin/spectinomycin and sulphonamides is closely related to antibiotic resistance segments found In IncW plasm ids and in Tn21-like transposons

1987 • 121 citations

The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7

1983 • 111 citations

Rapid and quantitative recovery of DNA fragments from gels by displacement electrophoresis (isotachophoresis)

1984 • 96 citations

Site-specific properties of Tn7 transposition into the E. coli Chromosome

1981 • 88 citations

Nucleotide sequence of the transposon Tn7 gene encoding an aminoglycoside-modifying enzyme, 3″(9)-O-nucleotidyltransferase

1985 • 87 citations

Homology of ORFs from Tn2603and from R46 to site-specific recombinases

1987 • 81 citations

A New Dihydrofolate Reductase with Low Trimethoprim Sensitivity Induced by an R Factor Mediating High Resistance to Trimethoprim

1974 • 80 citations

Cloning and sequencing of a gene encoding an aminoglycoside 6'-N-acetyltransferase from an R factor of Citrobacter diversus

1988 • 72 citations

Identification of the type I trimethoprim-resistant dihydrofolate reductase specified by the Escherichia coli R-plasmid R483: comparison with procaryotic and eucaryotic dihydrofolate reductases

1983 • 60 citations

Nucleotide sequence analysis of 2″‐aminoglycoside nucleotidyl‐transferase ANT(2″) from Tn4000: its relationship with AAD(3″) and impact on Tn21 evolution

1988 • 54 citations

A Practical Guide to Molecular Cloning (2nd ed)

1989 • 54 citations

Insertions of resistance genes into Tn21-like transposons

1986 • 53 citations

Novel type of plasmid-borne resistance to trimethoprim

1987 • 52 citations

Nudeotide sequence analysis of tbe trimethoprim resistant dihydrofolate reductase encoded by R plasmid R751

1986 • 49 citations

Characterization of Tn2411 and Tn2410, two transposons derived from R-plasmid R1767 and related to Tn2603 and Tn21

1983 • 48 citations

Relationships among the streptothricin resistance transposons Tn1825 and Tn1826 and the trimethoprim resistance transposon Tn7

1987 • 42 citations

The Changing Pattern of Trimethoprim Resistance in Paris, with a Review of Worldwide Experience

1986 • 40 citations

Plasmid-borne or chromosomally mediated resistance by Tn7 is the most common response to ubiquitous use of trimethoprim

1985 • 39 citations

Characterization of plasmid pAZ1 and the type III dihydrofolate reductase gene

1988 • 30 citations

Conservation of a common ‘backbone’ in the genetic organization of the incP plasmids RP4 and R751

1987 • 25 citations

R plasmid dihydrofolate reductase with a dimeric subunit structure.

1983 • 23 citations

Characterization of trimethoprim resistance by use of probes specific for transposon Tn7

1984 • 17 citations

Evolution of Tn21-related Transposons: Isolation of Tn2425, which Harbours IS161

1985 • 14 citations

New observations regarding evolution of trimethoprim resistance

1986 • 7 citations