An evolutionary approach to folding small alpha-helical proteins that uses sequence information and an empirical guiding fitness function.

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Artificial Intelligence through Simulated Evolution

1966 • 2,850 citations

A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure

1991 • 2,629 citations

Database of homology‐derived protein structures and the structural meaning of sequence alignment

1991 • 1,641 citations

Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-A resolution.

1981 • 1,432 citations

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

1990 • 996 citations

Genetic Algorithms for Protein Folding Simulations

1993 • 527 citations

Three-dimensional solution structure of the B domain of staphylococcal protein A: comparisons of the solution and crystal structures

1992 • 342 citations

Where metal ions bind in proteins.

1990 • 318 citations

Reduced representation model of protein structure prediction: Statistical potential and genetic algorithms

1993 • 212 citations

Potential of genetic algorithms in protein folding and protein engineering simulations

1992 • 127 citations

Structure of the amino-terminal domain of phage 434 represser at 2.0 Å resolution

1989 • 120 citations

Computer-aided model-building strategies for protein design

1986 • 107 citations

Fast approximations for accessible surface area and molecular volume of protein segments

1985 • 13 citations