Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae

Instability and decay of the primary structure of DNA

1993 • 5,370 citations

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

1999 • 2,095 citations

Rate of depurination of native deoxyribonucleic acid

1972 • 1,488 citations

REPAIR OF OXIDATIVE DAMAGE TO DNA: Enzymology and Biology

1994 • 1,435 citations

The RAD9 Gene Controls the Cell Cycle Response to DNA Damage in Saccharomyces cerevisiae

1988 • 1,174 citations

DNA damage and repair

2003 • 1,119 citations

DNA glycosylases in the base excision repair of DNA

1997 • 840 citations

Heat-induced deamination of cytosine residues in deoxyribonucleic acid

1974 • 725 citations

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

2002 • 693 citations

Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

1996 • 655 citations

Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid

1972 • 586 citations

Deoxycytidyl transferase activity of yeast REV1 protein

1996 • 566 citations

Oxidative damage to DNA: Formation, measurement, and biological significance

1997 • 431 citations

Nonenzymatic methylation of DNA by the intracellular methyl group donor S-adenosyl-L-methionine is a potentially mutagenic reaction.

1982 • 398 citations

Single-strand interruptions in replicating chromosomes cause double-strand breaks

2001 • 392 citations

Removal of Nonhomologous DNA Ends in Double-Strand Break Recombination: the Role of the Yeast Ultraviolet Repair Gene RAD1

1992 • 375 citations

Endogenous apurinic/apyrimidinic sites in genomic DNA of mammalian tissues.

1999 • 343 citations

Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sites

2001 • 338 citations

Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair

2002 • 335 citations

Insertion of nucleotides opposite apurinic apyrimidinic sites in deoxyribonucleic acid during in vitro synthesis: uniqueness of adenine nucleotides

1983 • 320 citations

Functional overlap between Sgs1–Top3 and the Mms4–Mus81 endonuclease

2001 • 315 citations

Alternative nucleotide incision repair pathway for oxidative DNA damage

2002 • 305 citations

Apurinic sites as mutagenic intermediates

1985 • 283 citations

Specific Cleavage of Model Recombination and Repair Intermediates by the Yeast Rad1-Rad10 DNA Endonuclease

1994 • 265 citations

Recent progress in the biology, chemistry and structural biology of DNA glycosylases

2001 • 257 citations

DNA postreplication repair and mutagenesis in Saccharomyces cerevisiae

2001 • 249 citations

Characterization of the Two Small Subunits of Saccharomyces cerevisiae DNA Polymerase δ

1998 • 221 citations

RAD1 and RAD10, but Not Other Excision Repair Genes, Are Required for Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae

1995 • 217 citations

Yeast Tdp1 and Rad1-Rad10 function as redundant pathways for repairing Top1 replicative damage

2002 • 211 citations

Cellular role of yeast Apn1 apurinic endonuclease/3'-diesterase: repair of oxidative and alkylation DNA damage and control of spontaneous mutation.

1991 • 211 citations

Nucleotide insertion kinetics opposite abasic lesions in DNA.

1987 • 209 citations

Overlapping Specificities of Base Excision Repair, Nucleotide Excision Repair, Recombination, and Translesion Synthesis Pathways for DNA Base Damage in Saccharomyces cerevisiae

1999 • 205 citations

Identification of APN2, the Saccharomyces cerevisiae homolog of the major human AP endonuclease HAP1, and its role in the repair of abasic sites

1998 • 201 citations

Yeast structural gene (APN1) for the major apurinic endonuclease: homology to Escherichia coli endonuclease IV.

1990 • 199 citations

Yeast DNA repair and recombination proteins Rad1 and Rad1O constitute a single-stranded-DNA endonuclease

1993 • 198 citations

Interaction with PCNA Is Essential for Yeast DNA Polymerase η Function

2001 • 195 citations

The Mechanism of Mus81-Mms4 Cleavage Site Selection Distinguishes It from the Homologous Endonuclease Rad1-Rad10

2003 • 192 citations

Generation of a strong mutator phenotype in yeast by imbalanced base excision repair

1998 • 189 citations

In vivo evidence for endogenous DNA alkylation damage as a source of spontaneous mutation in eukaryotic cells.

1993 • 177 citations

Release of normal bases from intact DNA by a native DNA repair enzyme

1998 • 176 citations

Mammalian DNA single‐strand break repair: an X‐ra(y)ted affair

2001 • 175 citations

Overlapping Functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 Nucleases in DNA Metabolism

2001 • 168 citations

Repair of topoisomerase I covalent complexes in the absence of the tyrosyl-DNA phosphodiesterase Tdp1

2002 • 165 citations

The Saccharomyces cerevisiae RAD6 Group Is Composed of an Error-Prone and Two Error-Free Postreplication Repair Pathways

2000 • 157 citations

Yeast Rev1 Protein Is a G Template-specific DNA Polymerase

2002 • 156 citations

The Saccharomyces cerevisiae Homologues of Endonuclease III from Escherichia coli, Ntg1 and Ntg2, Are Both Required for Efficient Repair of Spontaneous and Induced Oxidative DNA Damage in Yeast

1999 • 147 citations

Coding properties of poly(deoxycytidylic acid) templates containing uracil or apyrimidinic sites: in vitro modulation of mutagenesis by deoxyribonucleic acid repair enzymes

1982 • 142 citations

DNA repair synthesis during base excision repair in vitro is catalyzed by DNA polymerase epsilon and is influenced by DNA polymerases alpha and delta in Saccharomyces cerevisiae.

1993 • 141 citations

Cleavage Specificity of Saccharomyces cerevisiae Flap Endonuclease 1 Suggests a Double-Flap Structure as the Cellular Substrate

2002 • 140 citations

Role of the Rad1 and Rad10 Proteins in Nucleotide Excision Repair and Recombination

1995 • 134 citations

Determinants in nuclease specificity of ape1 and ape2, human homologues of Escherichia coli exonuclease III

2002 • 130 citations

Endogenous DNA abasic sites cause cell death in the absence of Apn1, Apn2 and Rad1/Rad10 in Saccharomyces cerevisiae

2002 • 127 citations

The Ogg1 protein of Saccharomyces cerevisiae: a 7,8-dihydro-8- oxoguanine DNA glycosylase/AP lyase whose lysine 241 is a critical residue for catalytic activity

1997 • 123 citations

Saccharomyces cerevisiae Ntg1p and Ntg2p: Broad Specificity N-Glycosylases for the Repair of Oxidative DNA Damage in the Nucleus and Mitochondria

1999 • 115 citations

Inefficient Bypass of an Abasic Site by DNA Polymerase η

2001 • 107 citations

Yeast DNA Polymerase ζ Is an Efficient Extender of Primer Ends Opposite from 7,8-Dihydro-8-Oxoguanine and O⁶-Methylguanine

2003 • 106 citations

Pir1p Mediates Translocation of the Yeast Apn1p Endonuclease into the Mitochondria To Maintain Genomic Stability

2001 • 105 citations

Specificity of the mutator caused by deletion of the yeast structural gene (APN1) for the major apurinic endonuclease.

1994 • 98 citations

The Stalling of Transcription at Abasic Sites Is Highly Mutagenic

2002 • 98 citations

Substrate specificities of the Ntg1 and Ntg2 proteins of Saccharomyces cerevisiae for oxidized DNA bases are not identical

1998 • 97 citations

Origin of Endogenous DNA Abasic Sites in Saccharomyces cerevisiae

2003 • 96 citations

Repair of oxidized DNA bases in the yeast Saccharomyces cerevisiae

1997 • 95 citations

Yeast DNA 3′-repair diesterase is the major cellular apurinic/apyrimidinic endonuclease: substrate specificity and kinetics.

1988 • 91 citations

Novel Mutagenic Properties of Abasic Sites inSaccharomyces cerevisiae

1995 • 89 citations

Evidence for the Involvement of Nucleotide Excision Repair in the Removal of Abasic Sites in Yeast

2000 • 84 citations

The Saccharomyces cerevisiae ETH1 Gene, an Inducible Homolog of Exonuclease III That Provides Resistance to DNA-Damaging Agents and Limits Spontaneous Mutagenesis

1999 • 83 citations

Repair of DNA Strand Breaks by the Overlapping Functions of Lesion-Specific and Non-Lesion-Specific DNA 3′ Phosphatases

2001 • 81 citations

Silent repair accounts for cell cycle specificity in the signaling of oxidative DNA lesions

2001 • 79 citations

Repair of chromosomal abasic sites in vivo involves at least three different repair pathways

2000 • 77 citations

Yeast as an honorary mammal

2000 • 76 citations

Apurinic Endonuclease Activity of Yeast Apn2 Protein

2000 • 73 citations

3′-Phosphodiesterase and 3′→5′ Exonuclease Activities of Yeast Apn2 Protein and Requirement of These Activities for Repair of Oxidative DNA Damage

2001 • 71 citations

Yeast DNA diesterase for 3′-fragments of deoxyribose: purification and physical properties of a repair enzyme for oxidative DNA damage.

1988 • 67 citations

Synergism between yeast nucleotide and base excision repair pathways in the protection against DNA methylation damage

1998 • 66 citations

Stimulation of 3′→5′ Exonuclease and 3′-Phosphodiesterase Activities of Yeast Apn2 by Proliferating Cell Nuclear Antigen

2002 • 61 citations

Uncoupling of 3′-Phosphatase and 5′-Kinase Functions in Budding Yeast

2001 • 59 citations

Relationships between yeast Rad27 and Apn1 in response to apurinic/apyrimidinic (AP) sites in DNA

1999 • 57 citations

Metalloenzymes in DNA repair. Escherichia coli endonuclease IV and Saccharomyces cerevisiae Apn1.

1991 • 54 citations

Intracellular localization of the Apn1 DNA repair enzyme of Saccharomyces cerevisiae. Nuclear transport signals and biological role.

1993 • 49 citations

Difference between deoxyribose- and tetrahydrofuran-type abasic sites in the in vivo mutagenic responses in yeast

2002 • 49 citations

Disparity between DNA base excision repair in yeast and mammals: translational implications.

2003 • 48 citations

Deletion of the MAG1 DNA glycosylase gene suppresses alkylation-induced killing and mutagenesis in yeast cells lacking AP endonucleases

2001 • 46 citations

The Role of Yeast DNA 3′-Phosphatase Tpp1 and Rad1/Rad10 Endonuclease in Processing Spontaneous and Induced Base Lesions

2003 • 39 citations

Partial Purification of Pde1 from Saccharomyces cerevisiae: Enzymatic Redundancy for the Repair of 3‘-Terminal DNA Lesions and Abasic Sites in Yeast

1997 • 27 citations

Uracil-DNA Glycosylases and DNA Uracil Repair

1989 • 26 citations