Stress and reactivation of latent herpes simplex virus: A fusion of behavioral medicine and molecular biology

Proceedings of the National Academy of Sciences of the United States of America

2009 • 5,771 citations

Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction

1992 • 5,105 citations

Psychological Stress and Susceptibility to the Common Cold

1991 • 1,679 citations

Epstein-Barr virus and its replication

1996 • 1,621 citations

Physiology of nerve growth factor.

1980 • 1,602 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor

1991 • 1,232 citations

Changes of nerve growth factor synthesis in nonneuronal cells in response to sciatic nerve transection.

1987 • 1,012 citations

Spousal caregivers of dementia victims: longitudinal changes in immunity and health.

1991 • 1,003 citations

Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve

1987 • 1,000 citations

Induction of Apoptosis by the Low-Affinity NGF Receptor

1993 • 774 citations

The Nerve Growth Factor: Biochemistry, Synthesis, and Mechanism of Action

1980 • 733 citations

Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration: role of macrophages.

1987 • 711 citations

Marital quality, marital disruption, and immune function.

1987 • 667 citations

Nerve growth factor in sympathetic ganglia and corresponding target organs of the rat: correlation with density of sympathetic innervation.

1983 • 564 citations

Infection with Herpes-Simplex Viruses 1 and 2

1973 • 500 citations

Stress, loneliness, and changes in herpesvirus latency

1985 • 500 citations

Psychosocial factors, immunologic mediation, and human susceptibility to infectious diseases: How much do we know?

1984 • 468 citations

Pathogenesis of Herpetic Neuritis and Ganglionitis in Mice: Evidence for Intra-Axonal Transport of Infection

1973 • 456 citations

Gene Transfer and Molecular Cloning of the Human NGF Receptor

1986 • 447 citations

An Extracellular Proteolytic Cascade Promotes Neuronal Degeneration in the Mouse Hippocampus

1997 • 421 citations

Nerve growth factor induces growth and differentiation of human B lymphocytes.

1989 • 386 citations

A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins.

1988 • 381 citations

Herpes simplex virus regulatory elements and the immunoglobulin octamer domain bind a common factor and are both targets for virion transactivation

1988 • 377 citations

Immediate-early regulatory gene mutants define different stages in the establishment and reactivation of herpes simplex virus latency

1989 • 372 citations

Stress-induced modulation of the immune response to recombinant hepatitis B vaccine.

1992 • 362 citations

A complex formed between cell components and an HSV structural polypeptide binds to a viral immediate early gene regulatory DNA sequence

1988 • 360 citations

Disruption of the low affinity receptor-binding site in NGF allows neuronal survival and differentiation by binding to the trk gene product

1992 • 336 citations

Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes

1982 • 315 citations

Comprehensive Virology

1975 • 254 citations

Interleukin 1 increases stability and transcription of mRNA encoding nerve growth factor in cultured rat fibroblasts.

1988 • 244 citations

Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream.

1986 • 242 citations

Herpes simplex virus type 1 ICP0 plays a critical role in the de novo synthesis of infectious virus following transfection of viral DNA

1989 • 237 citations

The Replication of Herpesviruses

1974 • 235 citations

Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins.

1987 • 217 citations

Psychosocial Risk Factors in the Developmental of Infectious Mononucleosis*

1979 • 187 citations

Herpes simplex virus latency

1984 • 180 citations

Activation of Latent Herpes Simplex by Trigeminal Sensory-Root Section

1952 • 178 citations

Cyclic AMP-induced shape changes of astrocytes are accompanied by rapid depolymerization of actin

1990 • 175 citations

Host cell proteins bind to the cis-acting site required for virion-mediated induction of herpes simplex virus 1 alpha genes.

1987 • 163 citations

Direct combinatorial interaction between a herpes simplex virus regulatory protein and a cellular octamer-binding factor mediates specific induction of virus immediate-early gene expression.

1988 • 157 citations

Chronic stress, leukocyte subpopulations, and humoral response to latent viruses.

1989 • 155 citations

Characterization of nerve growth factor-dependent herpes simplex virus latency in neurons in vitro

1988 • 151 citations

Nerve growth factor-dependence of herpes simplex virus latency in peripheral sympathetic and sensory neurons in vitro

1990 • 143 citations

Separation of sequences defining basal expression from those conferring alpha gene recognition within the regulatory domains of herpes simplex virus 1 alpha genes.

1984 • 140 citations

Stimulation of the pituitary-adrenocortical axis by nerve growth factor

1979 • 125 citations

The octamer-binding protein Oct-2 represses HSV immediate-early genes in cell lines derived from latently infectable sensory neurons

1991 • 120 citations

Reactivation of Herpes Simplex Virus after Decompression of the Trigeminal Nerve Root

1978 • 119 citations

alpha-Adrenergic regulation of secretion of mouse saliva rich in nerve growth factor.

1976 • 111 citations

Hybrid hybridomas and the production of bi-specific monoclonal antibodies

1984 • 111 citations

Influence of perceived psychological stress and distress on antibody response to low dose rDNA hepatitis B vaccine

1993 • 110 citations

Octamer motif mediates transcriptional repression of HSV immediate-early genes and octamer-containing cellular promoters in neuronal cells

1990 • 109 citations

NGF rescues substance P expression but not neurofilament or tubulin gene expression in axotomized sensory neurons

1991 • 108 citations

Psychological influences on immunity

1986 • 104 citations

Differential inhibition of nerve growth factor responses by purine analogues: correlation with inhibition of a nerve growth factor-activated protein kinase.

1989 • 101 citations

Pathogenesis of herpes simplex labialis: experimental induction of lesions with UV light

1985 • 92 citations

Receptors for nerve growth factor on rat spleen mononuclear cells

1987 • 81 citations

Synergism between protein‐kinase C and cAMP‐dependent pathways in the expression of the interleukin‐1β gene is mediated via the activator‐protein‐1 (AP‐1) enhancer activity

1993 • 81 citations

Health Psychology

1985 • 81 citations

The Influence of Conditioning on Immune Responses

1991 • 78 citations

Regulation of the Synthesis of Nerve Growth Factor

1987 • 77 citations

EGO STRENGTH AND LENGTH OF RECOVERY FROM INFECTIOUS MONONUCLEOSIS

1959 • 64 citations

Herpes Simplex Virus Latency

1985 • 63 citations

Herpes simplex virus and moods: A longitudinal study

1976 • 62 citations

Prediction of the Incidence of Recurrent Herpes Labialis and Systemic Illness from Psychological Measurements

1973 • 56 citations

Regulation of expression of the neuronal POU protein Oct-2 by nerve growth factor.

1992 • 55 citations

Recurrent Herpes Labialis, Recurrent Aphthous Ulcers, and the Menstrual Cycle

1974 • 54 citations

Cyclic nucleotides in mitogen-induced lymphocyte proliferation

1982 • 53 citations

Selective inhibition of responses to nerve growth factor and of microtubule-associated protein phosphorylation by activators of adenylate cyclase.

1986 • 51 citations

Retrograde Axonal Transport

1983 • 50 citations

Nerve growth factor levels in mouse serum: Variations due to stress

1987 • 45 citations

Activation of the cellular transcription factor AP-1 in herpes simplex virus infected cells is dependent on the viral immediate-early protein ICPO

1991 • 41 citations

Communication between Target Organs and Nerve Cells: Retrograde Axonal Transport and Site of Action of Nerve Growth Factor

1982 • 41 citations

Herpes Simplex Virus Infection of in vitro Cultured Neuronal Cells (Mouse Neuroblastoma C 1300 Cells)

1978 • 39 citations

CYCLIC NUCLEOTIDES IN LYMPHOCYTE FUNCTION

1975 • 32 citations

Decreased levels of nerve growth factor receptor on dexamethasone‐treated PC12 cells

1988 • 32 citations

Regulated transcription of herpes simplex virus immediate-early genes in neuroblastoma cells

1989 • 29 citations

¹²⁵I‐β‐nerve growth factor binding is reduced in rat brain after stress exposure

1990 • 27 citations

Activation of protein kinase C and elevation of cAMP interact synergistically to raise c-Fos and AP-1 activity in Jurkat cells

1992 • 24 citations

Cell lines derived from dorsal root ganglion neurons are nonpermissive for HSV and express only the latency-associated transcript following infection

1990 • 23 citations

Elevation of cyclic AMP levels in cell lines derived from latently infectable sensory neurons increases their permissivity for herpes virus infection by activating the viral immediate-early 1 gene promoter

1992 • 21 citations

Naturally occuring antibodies against nerve growth factor in human and rabbit sera: comparison between control and herpes simplex virus-infected patients

1991 • 14 citations

Role of the Herpes Simplex Virus 1 Internal Repeat Sequences in Pathogenicity

1990 • 13 citations

Intraocular herpes simplex virus injection in neonatal rats induces sympathetic nerve cell destruction: Effect of nerve growth factor

1987 • 13 citations

Costimulation of cAMP and Protein Kinase C Pathways Inhibits the CD3-Dependent T Cell Activation and Leads to a Persistent Expression of the AP-1 Transcription Factor

1993 • 6 citations

Stress-induced changes in the cyclic nucleotide concentrations and phosphorylase activity in the myocardium.

1991 • 2 citations

Autoreactive CD8+ cell responses to human myelin protein-derived peptides

1994 • 1 citations

Adrenocortical activity and plasma cAMP levels of humans under high altitude stress

1989 • 1 citations

Deleted Work

1955 • 0 citations