Regulation of 5-lipoxygenase activity by the glutathione status in human polymorphonuclear leukocytes

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

Tissue sulfhydryl groups

1959 • 25,130 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Glutathione S-Transferases

1974 • 17,321 citations

Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.

1968 • 5,084 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes

1979 • 812 citations

UV-Assay with Pyruvate and NADH

1974 • 580 citations

Diamide, a new reagent for the intracellular oxidation of glutathione to the disulfide

1969 • 523 citations

Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles

1969 • 353 citations

Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.

1986 • 311 citations

On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors.

1985 • 254 citations

Effects of glutathione-oxidizing agents on microtubule assembly and microtubule-dependent surface properties of human neutrophils.

1976 • 220 citations

Arachidonate 5-lipoxygenase of guinea pig peritoneal polymorphonuclear leukocytes. Activation by adenosine 5'-triphosphate.

1983 • 215 citations

Stimulation of leukotriene biosynthesis in human blood leukocytes by platelet-derived 12-hydroperoxy-icosatetraenoic acid.

1982 • 196 citations

Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids.

1986 • 191 citations

Characterization and separation of the arachidonic acid 5-lipoxygenase and linoleic acid omega-6 lipoxygenase (arachidonic acid 15-lipoxygenase) of human polymorphonuclear leukocytes.

1985 • 177 citations

Microtubule dynamics and glutathione metabolism in phagocytizing human polymorphonuclear leukocytes.

1978 • 166 citations

Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation.

1983 • 137 citations

The multiple roles of glutathione in drug metabolism

1984 • 132 citations

The importance of hydroperoxide activation for the detection and assay of mammalian 5‐lipoxygenase

1986 • 124 citations

Enzymatic assembly of slow reacting substance

1980 • 122 citations

Effects of fatty acids on Na+-Ca2+ exchange and Ca2+ permeability of cardiac sarcolemmal vesicles.

1985 • 110 citations

On the nature of the 5-lipoxygenase reaction in human leukocytes: characterization of a membrane-associated stimulatory factor.

1985 • 101 citations

Application of interferometry to reaction kinetics: hydrolysis of ethyl acetate

1969 • 96 citations

Calcium fluxes and calcium buffering in human neutrophils.

1986 • 89 citations

Changes in the levels of glutathione in phagocytosing human neutrophils

1980 • 59 citations

Leukotriene biosynthesis inhibitors.

1985 • 44 citations

Inhibition of mammalian 5-lipoxygenase by aromatic disulfides.

1985 • 37 citations

Effect of phagocytosis on the reduced soluble sulfhydryl content of human granulocytes

1977 • 32 citations

Regulation of intracellular arachidonate in normal and stressed endothelial cells

1984 • 28 citations

Leukotriene B4 synthesis and metabolism by neutrophils and granule-free cytoplasts

1986 • 27 citations

Ethanol-enhanced transmembrane penetration of arachidonic acid and activation of the 5-lipoxygenase pathway in human leukocytes

1986 • 17 citations

Mediated uptake of arachidonic acid by rabbit neutrophils

1981 • 5 citations

Requirement of free arachidonic acid for leukotriene B4 biosynthesis by 12-hydroperoxyeicosatetraenoic acid-stimulated neutrophils

1986 • 5 citations