Spontaneous inflammatory arthritis in HLA-B27 transgenic mice lacking beta 2-microglobulin: a model of human spondyloarthropathies.

ANKYLOSING SPONDYLITIS AND HL-A 27

1973 • 1,801 citations

Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: An animal model of HLA-B27-associated human disorders

1990 • 1,001 citations

Normal Development of Mice Deficient in β ₂ M, MCClass I Proteins, and CD8 ⁺ T Cells

1990 • 885 citations

Identification of self peptides bound to purified HLA-B27

1991 • 844 citations

Type II collagen-induced arthritis in mice. I. Major histocompatibility complex (I region) linkage and antibody correlates.

1981 • 705 citations

The three-dimensional structure of HLA-B27 at 2.1 Å resolution suggests a general mechanism for tight peptide binding to MHC

1992 • 670 citations

Monoclonal antibodies raised against denatured HLA-B locus heavy chains permit biochemical characterization of certain HLA-C locus products.

1986 • 547 citations

Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

1992 • 344 citations

Susceptibility to inflammatory disease in HLA-B27 transgenic rat lines correlates with the level of B27 expression.

1993 • 239 citations

Beta 2-microglobulin is not required for cell surface expression of the murine class I histocompatibility antigen H-2Db or of a truncated H-2Db.

1986 • 212 citations

The CD8+ T cell repertoire in beta 2-microglobulin-deficient mice is biased towards reactivity against self-major histocompatibility class I.

1994 • 97 citations

A hypothesis for the HLA-B27 immune dysregulation in spondyloarthropathy: contributions from enteric organisms, B27 structure, peptides bound by B27, and convergent evolution.

1993 • 93 citations

Assembly and Intracellular Transport of MHC Class I Molecules

1993 • 71 citations

An overview of clinical spectrum and heterogeneity of spondyloarthropathies.

1992 • 68 citations

Current perspectives in reactive arthritis

1993 • 66 citations

Polymorphism in an HLA linked proteasome gene influences phenotypic expression of disease in HLA-B27 positive individuals.

1994 • 46 citations

A monoclonal antibody that recognizes HLA-B27 in the context of peptides.

1994 • 45 citations

Polymorphism in the mouse Tap-1 gene. Association with abnormal CD8+ T cell development in the nonobese nondiabetic mouse.

1993 • 35 citations

Expression of HLA-B27 in transgenic mice is dependent on the mouse H-2D genes.

1990 • 24 citations

Beta 2-microglobulin independent presentation of exogenously added foreign peptide and endogenous self-epitope by MHC class I alpha-chain to a cross-reactive CD8+ CTL clone.

1994 • 21 citations

The effect of mutant beta 2-microglobulins on the conformation of HLA-B27 detected by antibody and by CTL.

1994 • 21 citations

Structure, function, and disease association of HLA-B27

1994 • 19 citations