Dexmedetomidine Partially Attenuates the Sympathetically Mediated Systemic and Coronary Hemodynamic Effects of Cocaine

Endothelium-dependent relaxation of coronary arteries by noradrenaline and serotonin

1983 • 855 citations

Medical Complications of Cocaine Abuse

1986 • 802 citations

Regional Myocardial Function during Acute Coronary Artery Occlusion and Its Modification by Pharmacologic Agents in the Dog

1974 • 711 citations

Alpha-2 adrenoceptor agonists: defining the role in clinical anesthesia.

1991 • 710 citations

Cocaine-Induced Coronary-Artery Vasoconstriction

1989 • 633 citations

Acute Cardiac Events Temporally Related to Cocaine Abuse

1986 • 610 citations

Alpha-2 Adrenoceptor Agonists

1991 • 550 citations

Reduced Narcotic Requirement by Clonidine with Improved Hemodynamic and Adrenergic Stability in Patients Undergoing Coronary Bypass Surgery

1987 • 455 citations

Effects of Clonidine on Narcotic Requirements and Hemodynamic Response during Induction of Fentanyl Anesthesia and Endotracheal Intubation

1986 • 349 citations

Cardiovascular effects of cocaine: An autopsy study of 40 patients

1988 • 325 citations

Anesthesia and hypertension: the effect of clonidine on perioperative hemodynamics and isoflurane requirements.

1987 • 313 citations

Work as a correlate of canine left ventricular oxygen consumption, and the problem of catecholamine oxygen wasting.

1982 • 278 citations

Competition between sympathetic vasoconstriction and metabolic vasodilation in the canine coronary circulation.

1978 • 274 citations

Anesthesia and Hypertension

1987 • 261 citations

Acute Systemic Effects of Cocaine in Man: A Controlled Study by Intranasal and Intravenous Routes

1977 • 256 citations

Intramuscularly Administered Dexmedetomidine Attenuates Hemodynamic and Stress Hormone Responses to Gynecologic Laparoscopy

1992 • 148 citations

Dexmedetomidine Infusion for Maintenance of Anesthesia in Patients Undergoing Abdominal Hysterectomy

1992 • 136 citations

Pharmacology and Therapeutic Applications of Cocaine

1990 • 135 citations

Endothelial α2-adrenoceptors in canine pulmonary and systemic blood vessels

1985 • 134 citations

Pharmacological characterisation of the ?-adrenoceptors responsible for a decrease of blood pressure in the nucleus tractus solitarii of the rat

1981 • 130 citations

Cardiovascular effects of cocaine in conscious dogs: importance of fully functional autonomic and central nervous systems.

1988 • 129 citations

The nucleus reticularis lateralis: A region highly sensitive to clonidine

1981 • 127 citations

Centrally mediated release by cocaine of endogenous epinephrine and norepinephrine from the sympathoadrenal medullary system of unanesthetized rats.

1978 • 126 citations

Clonidine Reduces Sympathetic Activity but Maintains Baroreflex Responses in Normotensive Humans

1992 • 124 citations

Inhibition of neuronal uptake reduces the presynaptic effects of clonidine but not of α-methylnoradrenaline on the stimulation-evoked release of 3H-noradrenaline from rat occipital cortex slices

1980 • 111 citations

The Effects of the Stereoisomers of the α2-Adrenergic Agonist Medetomidine on Systemic and Coronary Hemodynamics in Conscious Dogs

1991 • 99 citations

Unrecognized left ventricular dysfunction in an apparently healthy cocaine abuse population

1990 • 94 citations

Hemodynamic effects of intranasal cocaine in humans

1992 • 91 citations

Myocardial Infarction With Topical Cocaine Anesthesia for Nasal Surgery

1986 • 90 citations

Aortic surgery: effect of clonidine on intraoperative catecholaminergic and circulatory stability

1990 • 88 citations

Adverse effects of cocaine on cardiovascular dynamics, myocardial blood flow, and coronary artery diameter in an experimental model

1989 • 86 citations

Role of the central nervous system in hemodynamic and sympathoadrenal responses to cocaine in rats.

1990 • 84 citations

EFFECT OF CLONIDINE ON THE CIRCULATION AND VASOACTIVE HORMONES AFTER AORTIC SURGERY

1991 • 83 citations

Adrenergic blockade blunts adenosine concentration and coronary vasodilation during hypoxia.

1992 • 73 citations

Cardiovascular responses to cocaine are initially mediated by the central nervous system in rats.

1992 • 72 citations

Electrocardiographic and hemodynamic effects of intravenous cocaine in awake and anesthetized dogs

1989 • 72 citations

Cocaine-induced closures of single batrachotoxin-activated Na+ channels in planar lipid bilayers.

1988 • 70 citations

Effect of cocaine on the coronary circulation and systemic hemodynamics in dogs

1990 • 67 citations

Direct Coronary and Cerebral Vascular Responses to Dexmedetomidine

1992 • 63 citations

Anaesthesia for laryngoscopy

1968 • 61 citations

Postjunctional α₂‐adrenoceptors mediate vasoconstriction in human subcutaneous resistance vessels

1989 • 53 citations

Pathophysiological and pharmacological mechanisms of acute cocaine toxicity in conscious rats.

1992 • 47 citations

Cardiovascular effects of cocaine in conscious rats: relative significance of central sympathetic stimulation and peripheral neuronal monoamine uptake and release mechanisms.

1992 • 47 citations

Acute cocaine toxicity: Antagonism by agents interacting with adrenoceptors

1990 • 36 citations

Oral Dexmedetomidine Attenuates Hemodynamic Responses during Emergence from General Anesthesia in Chronically Instrumented Dogs

1991 • 35 citations

Is Cocaine a Sympathetic Stimulant During General Anesthesia?

1980 • 34 citations

Adrenergic mechanisms underlying cardiac and vascular responses to cocaine in conscious rats.

1992 • 32 citations

Attenuation of the systemic and coronary hemodynamic effects of cocaine in conscious dogs: propranolol versus labetalol

1992 • 28 citations

Adrenergic Vasomotion in the Coronary Microcirculation

1991 • 27 citations

Alpha-adrenergic regulation of the coronary circulation in the conscious dog

1983 • 26 citations

Alpha adrenoceptor regulation of coronary artery blood flow in normal and stenotic canine coronary arteries.

1986 • 26 citations

Transient time course of cocaine-induced cardiac depression versus sustained peripheral vasoconstriction

1993 • 25 citations

Cocaine sensitization of coronary artery contractions: mechanism of drug-induced spasm.

1993 • 25 citations

Topical cocaine and general anaesthesia: an investigation of the efficacy and side effects of cocaine on the nasal mucosae

1975 • 23 citations

Cocaine Depresses Myocardial Contractility and Prolongs Isovolumetric Relaxation in Conscious Dogs with Partial Autonomic Nervous System Blockade

1992 • 21 citations

Isoflurane Causes Only Minimal Increases in Coronary Blood Flow Independent of Oxygen Demand

1991 • 19 citations

Severe hypertension during anaesthesia for dacryocystorhinostomy

1985 • 18 citations

Systemic and Coronary Hemodynamic Effects of Repetitive Cocaine Administration in Conscious Dogs

1994 • 17 citations

Premedication with Oral Dexmedetomidine Alters Hemodynamic Actions of Intravenous Anesthetic Agents in Chronically Instrumented Dogs

1992 • 17 citations