From Halsted to prevention and beyond: advances in the management of breast cancer during the twentieth century

The Structure of Scientific Revolutions

2017 • 5,532 citations

Tamoxifen for Prevention of Breast Cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study

1998 • 5,487 citations

The Structure of Scientific Revolutions

1984 • 2,244 citations

Effect of preoperative chemotherapy on the outcome of women with operable breast cancer.

1998 • 2,115 citations

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy

1992 • 2,084 citations

Effect of preoperative chemotherapy on local-regional disease in women with operable breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-18.

1997 • 1,783 citations

ON THE TREATMENT OF INOPERABLE CASES OF CARCINOMA OF THE MAMMA: SUGGESTIONS FOR A NEW METHOD OF TREATMENT, WITH ILLUSTRATIVE CASES.

1896 • 1,633 citations

Comparing Radical Mastectomy with Quadrantectomy, Axillary Dissection, and Radiotherapy in Patients with Small Cancers of the Breast

1981 • 1,581 citations

Reanalysis and Results after 12 Years of Follow-up in a Randomized Clinical Trial Comparing Total Mastectomy with Lumpectomy with or without Irradiation in the Treatment of Breast Cancer

1995 • 1,480 citations

A Randomized Clinical Trial Evaluating Tamoxifen in the Treatment of Patients with Node-Negative Breast Cancer Who Have Estrogen-Receptor–Positive Tumors

1989 • 1,471 citations

Ten-Year Results of a Randomized Clinical Trial Comparing Radical Mastectomy and Total Mastectomy with or without Radiation

1985 • 1,384 citations

Combination Chemotherapy as an Adjuvant Treatment in Operable Breast Cancer

1976 • 1,333 citations

METHODS IN CANCER RESEARCH

1969 • 1,197 citations

Tamoxifen in treatment of intraductal breast cancer: National Surgical Adjuvant Breast and Bowel Project B-24 randomised controlled trial

1999 • 1,034 citations

Effects of Adjuvant Tamoxifen and of Cytotoxic Therapy on Mortality in Early Breast Cancer

1988 • 921 citations

Streptomycin Treatment of Pulmonary Tuberculosis: A Medical Research Council Investigation

1948 • 880 citations

Five Versus More Than Five Years of Tamoxifen Therapy for Breast Cancer Patients With Negative Lymph Nodes and Estrogen Receptor-Positive Tumors

1996 • 870 citations

THE RESULTS OF RADICAL OPERATIONS FOR THE CURE OF CARCINOMA OF THE BREAST.*

1907 • 844 citations

Lumpectomy Compared with Lumpectomy and Radiation Therapy for the Treatment of Intraductal Breast Cancer

1993 • 832 citations

L-Phenylalanine Mustard (L-PAM) in the Management of Primary Breast Cancer

1975 • 752 citations

Effects of adjuvant tamoxifen and of cytotoxic therapy on mortality in early breast cancer. An overview of 61 randomized trials among 28,896 women

1988 • 631 citations

STREPTOMYCIN treatment of pulmonary tuberculosis.

1948 • 610 citations

Tamoxifen and Chemotherapy for Lymph Node-Negative, Estrogen Receptor-Positive Breast Cancer

1997 • 525 citations

Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata

1976 • 377 citations

Laboratory and clinical research in breast cancer--a personal adventure: the David A. Karnofsky memorial lecture.

1980 • 367 citations

Ten year follow-up results of patients with carcinoma of the breast in a co-operative clinical trial evaluating surgical adjuvant chemotherapy.

1975 • 367 citations

What is Efficient Vaccination?

1891 • 348 citations

Tamoxifen in advanced breast cancer

1978 • 343 citations

Increased intensification and total dose of cyclophosphamide in a doxorubicin-cyclophosphamide regimen for the treatment of primary breast cancer: findings from National Surgical Adjuvant Breast and Bowel Project B-22.

1997 • 316 citations

Postoperative chemotherapy and tamoxifen compared with tamoxifen alone in the treatment of positive-node breast cancer patients aged 50 years and older with tumors responsive to tamoxifen: results from the National Surgical Adjuvant Breast and Bowel Project B-16.

1990 • 296 citations

CONTROLLED TRIAL OF TAMOXIFEN AS SINGLE ADJUVANT AGENT IN MANAGEMENT OF EARLY BREAST CANCER

1985 • 291 citations

The cytologic demonstration and significance of tumor cells in the mesenteric venous blood in patients with colorectal carcinoma.

1955 • 243 citations

Endogenous Factors Influencing Host-Tumor Balance.

1967 • 241 citations

Kinetics of mammary tumor cell growth and implications for therapy

1971 • 240 citations

Further Evaluation of Intensified and Increased Total Dose of Cyclophosphamide for the Treatment of Primary Breast Cancer: Findings From National Surgical Adjuvant Breast and Bowel Project B-25

1999 • 231 citations

Cancer invasion and metastasis : biologic and therapeutic aspects

1984 • 221 citations

Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy 133 randomised trials involving 31 000 recurrences and 24 000 deaths among 75 000 women

1992 • 217 citations

Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial.

1986 • 215 citations

Methods in Cancer Research.

1967 • 213 citations

Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model

1980 • 212 citations

Infection in Infancy

1965 • 211 citations

Adjuvant Chemotherapy for Breast Cancer

1985 • 183 citations

I. A Clinical and Histological Study of certain Adenocarcinomata of the Breast: and a Brief Consideration of the Supraclavicular Operation and of the Results of Operations for Cancer of the Breast from 1889 to 1898 at the Johns Hopkins Hospital.

1898 • 173 citations

The evolution of paradigms for the management of breast cancer: a personal perspective.

1992 • 158 citations

ADJUVANT TAMOXIFEN IN THE MANAGEMENT OF OPERABLE BREAST CANCER: THE SCOTTISH TRIAL

1987 • 145 citations

The development of tamoxifen for breast cancer therapy: A tribute to the late Arthur L. Walpole

1988 • 130 citations

New Perspective on Cancer of the Contralateral Breast: A Marker for Assessing Tamoxifen as a Preventive Agent

1991 • 111 citations

Non-steroidal antioestrogens—Receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells

1984 • 110 citations

Preoperative chemotherapy: a model for studying the biology and therapy of primary breast cancer.

1995 • 108 citations

A role for chemotherapy as an adjunct to surgery.

1957 • 92 citations

The surgical dilemma in the primary therapy of invasive breast cancer: A critical appraisal

1970 • 86 citations

CONTROLLED TRIAL OF TAMOXIFEN AS ADJUVANT AGENT IN MANAGEMENT OF EARLY BREAST CANCER

1983 • 65 citations

Current overview of EORTC clinical trials with tamoxifen.

1976 • 55 citations

Tamoxifen (Nolvadex) for premenopausal patients with advanced breast cancer

1984 • 41 citations

National Surgical Adjuvant Breast and Bowel Project Breast Cancer Prevention Trial: A Reflective Commentary

1999 • 38 citations

Tamoxifen. Use in treatment of metastatic breast cancer refractory to combination chemotherapy

1979 • 34 citations

Effect of anti-oestrogens on initiation of mammary cancer in the female rat

1971 • 33 citations

Tamoxifen

1979 • 26 citations

X-Ray Treatment: Its Origin, Birth and Early History

1950 • 24 citations

The evolution of mammography.

1992 • 14 citations

Laboratory and clinical research in breast cancer—A personal adventure

1981 • 14 citations

Current Concepts in Surgery.

1965 • 11 citations

HIV-l infection diagnosis and management

1992 • 10 citations

Progress in Anti-Cancer Chemotherapy

2000 • 9 citations

The interdependence of laboratory and clinical research in the study of metastases.

1983 • 7 citations

Biologic aspects of cancer-cell spread.

1964 • 7 citations

National Surgical Adjuvant Breast and Bowel Project's Breast Cancer Prevention Trial.

1993 • 6 citations

Estrogens, receptors and cancer: the scientific contributions of Elwood Jensen.

1990 • 4 citations

Compliance with quality of life data collection in the National Surgical Adjuvant Breast and Bowel Project (NSABP) Breast Cancer Prevention Trial

1998 • 2 citations

A Personal Perspective About the Future of Breast Cancer Research and Treatment

2000 • 1 citations

Sixth annual Wendell G. Scott Memorial lecture

1979 • 1 citations