Pioglitazone is Metabolised by CYP2C8 and CYP3A4 in vitro: Potential for Interactions with CYP2C8 Inhibitors

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1995 • 601 citations

Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

1994 • 407 citations

Gemfibrozil and Its Glucuronide Inhibit the Organic Anion Transporting Polypeptide 2 (OATP2/OATP1B1:SLC21A6)-Mediated Hepatic Uptake and CYP2C8-Mediated Metabolism of Cerivastatin: Analysis of the Mechanism of the Clinically Relevant Drug-Drug Interaction between Cerivastatin and Gemfibrozil

2004 • 403 citations

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.

1996 • 358 citations

Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes

1998 • 334 citations

Gemfibrozil greatly increases plasma concentrations of cerivastatin

2002 • 334 citations

GLUCURONIDATION CONVERTS GEMFIBROZIL TO A POTENT, METABOLISM-DEPENDENT INHIBITOR OF CYP2C8: IMPLICATIONS FOR DRUG-DRUG INTERACTIONS

2005 • 321 citations

Ketoconazole and sulphaphenazole as the respective selective inhibitors of P4503A and 2C9

1995 • 295 citations

Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics and pharmacodynamics of repaglinide: potentially hazardous interaction between gemfibrozil and repaglinide

2003 • 276 citations

ROLE OF ITRACONAZOLE METABOLITES IN CYP3A4 INHIBITION

2004 • 258 citations

Potent Mechanism-Based Inhibition of Human CYP2B6 by Clopidogrel and Ticlopidine

2003 • 253 citations

Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone

1999 • 230 citations

Evaluation of omeprazole and lansoprazole as inhibitors of cytochrome P450 isoforms.

1997 • 208 citations

Gemfibrozil considerably increases the plasma concentrations of rosiglitazone

2003 • 188 citations

Gemfibrozil Inhibits CYP2C8-Mediated Cerivastatin Metabolism in Human Liver Microsomes

2002 • 186 citations

Examination of 209 Drugs for Inhibition of Cytochrome P450 2C8

2004 • 178 citations

Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes.

1991 • 170 citations

Trimethoprim and Sulfamethoxazole are Selective Inhibitors of CYP2C8 and CYP2C9, Respectively

2002 • 169 citations

Metabolism of Repaglinide by CYP2C8 and CYP3A4 in vitro: Effect of Fibrates and Rifampicin

2005 • 169 citations

Clinical pharmacokinetics of pioglitazone

2000 • 161 citations

Effect of clopidogrel and ticlopidine on cytochrome P450 2B6 activity as measured by bupropion hydroxylation

2005 • 154 citations

SELECTIVE INHIBITION OF HUMAN CYTOCHROME P4502C8 BY MONTELUKAST

2004 • 152 citations

Prediction of Drug Metabolism and Interactions on the Basis of in vitro Investigations

2005 • 145 citations

Gemfibrozil is a potent inhibitor of human cytochrome P450 2C9.

2001 • 135 citations

Effects of gemfibrozil, itraconazole, and their combination on the pharmacokinetics of pioglitazone

2005 • 115 citations

Effects of trimethoprim and rifampin on the pharmacokinetics of the cytochrome P450 2C8 substrate rosiglitazone

2004 • 99 citations

Simultaneous determination of pioglitazone and its two active metabolites in human plasma by LC–MS/MS

2003 • 96 citations

The xenobiotic inhibitor profile of cytochrome P4502C8

2000 • 87 citations

Effect of rifampicin on the pharmacokinetics of pioglitazone

2005 • 86 citations

Rifampicin seems to act as both an inducer and an inhibitor of the metabolism of repaglinide

2004 • 80 citations

Pharmacokinetics and clinical efficacy of pioglitazone.

2001 • 75 citations

Midazolam α‐Hydroxylation by Human Liver Microsomes in vitro: Inhibition by Calcium Channel Blockers, Itraconazole and Ketoconazole

1999 • 66 citations

The effect of trimethoprim on CYP2C8 mediated rosiglitazone metabolism in human liver microsomes and healthy subjects

2004 • 60 citations

Effect of gemfibrozil on the pharmacokinetics and pharmacodynamics of racemic warfarin in healthy subjects

2005 • 44 citations

Enhancement of type II substrate oxidation and of azo reduction in the isolated rat liver and in vitro by metyrapone.

1973 • 6 citations