The CD4 molecule transmits biochemical information important in the regulation of T lymphocyte activity

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using protein A-Sepharose

1978 • 2,726 citations

Fluorographic detection of radioactivity in polyacrylamide gols with the water-soluble fluor, sodium salicylate

1979 • 1,976 citations

In vitro methods in cell-mediated and tumor immunity

1976 • 1,266 citations

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

1985 • 742 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family

1985 • 669 citations

Inhibition of Lymphocyte Proliferation by a Synthetic Peptide Homologous to Retroviral Envelope Proteins

1985 • 433 citations

Immunologic Abnormalities in the Acquired Immunodeficiency Syndrome

1985 • 380 citations

Perturbation of the T4 molecule transmits a negative signal to T cells.

1985 • 335 citations

Evidence for a physical association of CD4 and the CD3: α : β T-cell receptor

1987 • 265 citations

Expression and function of CD4 in a murine T-cell hybridoma

1987 • 208 citations

Early Signal Transduction by the Antigen Receptor Without Commitment to T Cell Activation

1988 • 169 citations

Role of the L3T4-antigen in T cell activation. II. Inhibition of T cell activation by monoclonal anti-L3T4 antibodies in the absence of accessory cells.

1985 • 167 citations

HTLV-III large envelope protein (gp120) suppresses PHA-induced lymphocyte blastogenesis.

1987 • 160 citations

Inhibition of CD4+ T cell function by the HIV envelope protein, gp120.

1988 • 160 citations

Functional and Molecular Aspects of Human T Lymphocyte Activation via T3‐Ti and Tl1 Pathways

1987 • 152 citations

Mitogenesis in Response to PDGF and Bombesin Abolished by Microinjection of Antibody to PIP ₂

1988 • 146 citations

Cross-linking of surface immunoglobulin on B lymphocytes induces both intracellular Ca2+ release and Ca2+ influx: Analysis with indo-1

1986 • 112 citations

Antibody-induced modulation of the CD3/T cell receptor complex causes T cell refractoriness by inhibiting the early metabolic steps involved in T cell activation.

1987 • 74 citations

Synthetic peptides homologous to HIV transmembrane glycoprotein suppress normal human lymphocyte blastogenic response

1988 • 70 citations

Five epitopes of a differentiation antigen on human inducer T cells distinguished by monoclonal antibodies

1983 • 69 citations

Regulation of the alternative pathway of T cell activation by anti-T3 monoclonal antibody

1986 • 55 citations

Role of phosphoinositide-derived second messengers in mediating anti-IgM-induced growth arrest of WEHI-231 B lymphoma cells.

1988 • 46 citations

Regulation of T cell clone function via CD4 and CD8 molecules. Anti-CD4 can mediate two distinct inhibitory activities.

1988 • 40 citations

Regulation of the alternative pathway of T cell activation by anti-T3 monoclonal antibody.

1986 • 38 citations

Participation of L3T4 in T cell activation in the absence of class II major histocompatibility complex antigens. Inhibition by anti-L3T4 antibodies is a function both of epitope density and mode of presentation of anti-receptor antibody.

1987 • 36 citations

Regulation of the CD2 alternate pathway of T cell activation by CD3. Evidence for heterologous desensitization.

1988 • 22 citations

The selective activation of T8+ cells by neuraminidase and galactose oxidase is mediated by activated T4+ cells

1987 • 1 citations