Novel, Ultraslow Inactivating Sodium Current in Human Ventricular Cardiomyocytes

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches

1981 • 18,584 citations

Ionic channels of excitable membranes

1985 • 7,199 citations

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction

1996 • 1,352 citations

Ionic Channels of Excitable Membranes, 2nd Ed.

1992 • 1,283 citations

Molecular mechanism for an inherited cardiac arrhythmia

1995 • 964 citations

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

Alterations of K+ currents in isolated human ventricular myocytes from patients with terminal heart failure.

1993 • 717 citations

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

1992 • 624 citations

Ionic Mechanism of Action Potential Prolongation in Ventricular Myocytes From Dogs With Pacing-Induced Heart Failure

1996 • 573 citations

The steady state TTX-sensitive (?window?) sodium current in cardiac Purkinje fibres

1979 • 468 citations

Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II

1991 • 460 citations

Structure and Function of a Novel Voltage-gated, Tetrodotoxin-resistant Sodium Channel Specific to Sensory Neurons

1996 • 424 citations

A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel

1994 • 274 citations

A Phosphorylation Site in the Na ⁺ Channel Required for Modulation by Protein Kinase C

1991 • 252 citations

Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine.

1992 • 247 citations

Slow currents through single sodium channels of the adult rat heart.

1985 • 242 citations

Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure.

1993 • 233 citations

Physiology and Pathophysiology of the Heart

1989 • 214 citations

Block of inactivated sodium channels and of depolarization-induced automaticity in guinea pig papillary muscle by amiodarone.

1984 • 213 citations

Triggered activity and automaticity in ventricular trabeculae of failing human and rabbit hearts

1994 • 213 citations

A persistent sodium current in rat ventricular myocytes.

1992 • 199 citations

Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes.

1989 • 192 citations

Characterization of Inwardly Rectifying K ⁺ Channel in Human Cardiac Myocytes

1995 • 171 citations

Molecular cloning of an atypical voltage-gated sodium channel expressed in human heart and uterus: evidence for a distinct gene family.

1992 • 145 citations

Slow inactivation of the sodium current in rabbit cardiac Purkinje fibres

1987 • 140 citations

Modulation of Cardiac Na+ Channel Expression in Xenopus Oocytes by β1 Subunits

1995 • 137 citations

Cytoskeleton modulates gating of voltage-dependent sodium channel in heart

1995 • 123 citations

Sodium current in isolated human ventricular myocytes

1993 • 102 citations

Characterization of the sodium current in single human atrial myocytes.

1992 • 101 citations

Modal gating behavior of cardiac sodium channels in cell-free membrane patches

1988 • 96 citations

Electrophysiologic and Extracellular Ionic Changes During Acute Ischemia in Failing and Normal Rabbit Myocardium

1996 • 64 citations

Basis for tetrodotoxin and lidocaine effects on action potentials in dog ventricular myocytes

1988 • 63 citations

Cytoskeleton modulates coupling between availability and activation of cardiac sodium channel

1997 • 55 citations

A Novel Tetrodotoxin-Sensitive Na sup + Current in Cultured Human Coronary Myocytes

1997 • 49 citations

Relationship between action potential, contraction-relaxation pattern, and intracellular Ca 2+ transient in cardiomyocytes of dogs with chronic heart failure

1998 • 39 citations

Arrhythmogenic effects of catecholamines are decreased in heart failure induced by rapid pacing in dogs

1993 • 23 citations

Ionic Basis of Electrical Activity in the Heart

1989 • 17 citations

Voltage-dependent properties of three different gating modes in single cardiac Na+ channels

1995 • 15 citations

Electromechanical effects of caffeine in failing human ventricular myocardium

1995 • 12 citations