Relationship of Hydroxyproline Excretion in Urine to Collagen Metabolism

Two Improved and Simplified Methods for the Spectrophotometric Determination of Hydroxyproline.

1963 • 1,523 citations

THE DETERMINATION OF HYDROXYPROLINE

1950 • 1,428 citations

Modifications of a specific assay for hydroxyproline in urine

1967 • 1,091 citations

A specific method for the analysis of hydroxyproline in tissues and urine

1960 • 1,065 citations

THE DETERMINATION OF COLLAGEN AND ELASTIN IN TISSUES

1950 • 826 citations

The Chromatographic Separation and Amino Acid Composition of the Subunits of Several Collagens^*

1963 • 706 citations

[Microdetermination of hydroxyproline with chloramine-T and p-dimethylaminobenzaldehyde].

1958 • 626 citations

The Structure Of Collagen And Gelatin

1962 • 391 citations

ALTERATIONS IN STATE OF MOLECULAR AGGREGATION OF COLLAGEN INDUCED IN CHICK EMBRYOS BY ß-AMINOPROPIONITRILE (LATHYRUS FACTOR)

1959 • 310 citations

SOME ASPECTS OF THE METABOLISM OF HYDROXYPROLINE, STUDIED WITH THE AID OF ISOTOPIC NITROGEN

1949 • 277 citations

Involvement of RNA in the Synthesis of Proteins

1963 • 267 citations

STUDIES ON THE FORMATION OF COLLAGEN

1958 • 241 citations

On the Significance of the Extractable Collagens

1960 • 233 citations

Connective tissue growth stimulated by carrageenin. 1. The formation and removal of collagen

1957 • 228 citations

The metabolism of collagen from liver, bone, skin and tendon in the normal rat

1953 • 213 citations

The relative metabolic inertia of tendon collagen in the rat

1951 • 200 citations

The metabolism of collagen and other proteins of the skin of rabbits

1954 • 199 citations

RELATIONSHIP BETWEEN URINARY HYDROXYPROLINE AND GROWTH*

1962 • 196 citations

Urinary Hydroxyproline as an Index of Collagen Turnover in Bone

1963 • 194 citations

ENZYMATIC HYDROXYLATION OF PROLINE IN MICROSOMAL POLYPEPTIDE LEADING TO FORMATION OF COLLAGEN

1965 • 184 citations

EXTRACTION OF COLLAGEN FROM CONNECTIVE TISSUE BY NEUTRAL SALT SOLUTIONS

1955 • 183 citations

Hydroxylation of Proline and the Intracellular Accumulation of a Polypeptide Precursor of Collagen

1966 • 180 citations

SIGNIFICANCE OF URINARY HYDROXYPROLINE IN MAN

1961 • 180 citations

Conversion of Proline to Collagen Hydroxyproline in a Cell-free System from Chick Embryo

1963 • 180 citations

Catabolism of collagen and non-collagen protein in the rat uterus during post-partum involution

1962 • 179 citations

THE METABOLISM OF l(-)-PROLINE STUDIED WITH THE AID OF DEUTERIUM AND ISOTOPIC NITROGEN

1944 • 176 citations

ENZYMATIC HYDROXYLATION OF PROLINE AND LYSINE IN PROTOCOLLAGEN

1967 • 171 citations

EXCRETION OF HYDROXYPROLINE IN PATIENTS WITH RHEUMATIC AND NON-RHEUMATIC DISEASES 1

1956 • 162 citations

Function of Ascorbic Acid in the Conversion of Proline to Collagen Hydroxyproline

1962 • 158 citations

Isotopic Studies on Collagen Degradation and the Urine Excretion of Hydroxyproline *

1964 • 152 citations

Requirements for α-ketoglutarate, ferrous ion and ascorbate by collagen proline hydroxylase

1966 • 148 citations

On the intramolecular cross-linking of collagen in lathyritic rats

1961 • 148 citations

Formation of collagen hydroxyproline in vitro

1959 • 148 citations

Isotopic Studies on Urinary Hydroxyproline as Evidence for Rapidly Catabolized Forms of Collagen in the Young Rat

1961 • 148 citations

HYDROXYPROLINE CREATININE RATIO AS AN INDEX OF NUTRITIONAL STATUS AND RATE OF GROWTH

1965 • 131 citations

SYNTHESIS OF HYDROXYPROLINE IN VITRO BY THE HYDROXYLATION OF PROLINE IN A PRECURSOR OF COLLAGEN

1965 • 130 citations

The determination of total hydroxyproline in urine and bone extracts

1966 • 128 citations

A Hydroxyproline-containing, Collagen-like Protein in Plasma and a Procedure for Its Assay

1964 • 124 citations

Influence of chelating agents on the biosynthesis of collagen

1965 • 119 citations

GASTROINTESTINAL ABSORPTION AND RENAL EXCRETION OF HYDROXYPROLINE PEPTIDES

1962 • 118 citations

Incorporation of 18O from air into hydroxyproline by chick embryo

1962 • 113 citations

URINARY HYDROXYPROLINE PEPTIDES*

1963 • 110 citations

Purification and partial characterization of the enzyme for the hydroxylation of proline in protocollagen

1967 • 106 citations

INCREASED EXCRETION OF HYDROXYPROLINE IN MARFAN'S SYNDROME

1958 • 102 citations

Modes of Intermolecular Cross-linking in Mature Insoluble Collagen

1965 • 101 citations

Correlation of urinary hydroxyproline, serum alkaline phosphatase and skeletal calcium turnover

1964 • 92 citations

STUDIES ON THE FORMATION OF COLLAGEN

1958 • 91 citations

Hydroxyproline in the Serum and Urine Normal Values and Clinical Significance

1966 • 86 citations

Evidence for the Nature of the Precursor That Is Hydroxylated during the Biosynthesis of Collagen Hydroxyproline

1965 • 84 citations

THE BIOCHEMICAL ROLE OF ASCORBIC ACID IN CONNECTIVE TISSUE*

1961 • 81 citations

THE CONVERSION OF LYSINE TO HYDROXYLYSINE AND ITS RELATION TO THE BIOSYNTHESIS OF COLLAGEN IN SEVERAL TISSUES OF THE RAT

1957 • 79 citations

Oxygen-18 studies on the conversion of proline to collagen hydroxyproline

1963 • 79 citations

Hydroxyproline Excretion in Endocrine Disease

1963 • 77 citations

Hydroxyprolinemia

1965 • 75 citations

THE SOURCE AND STATE OF THE HYDROXYLYSINE OF COLLAGEN

1955 • 75 citations

Proposed Mode of Action of Corticosteroids on the Connective Tissue

1965 • 73 citations

Studies on the Intracellular Localization of Collagen Synthesis in the Intact Chick Embryo

1962 • 70 citations

Studies with 14C-proline on the action of cortisone on the metabolism of collagen in the rat

1965 • 69 citations

The urinary excretion of amino acids and sugars in early infancy

1957 • 69 citations

Partial characterization of protocollagen from embryonic cartilage

1967 • 67 citations

Hydroxyproline and Collagen Metabolism: Clinical Implications: Combined Clinical Staff Conference at the National Institutes of Health

1965 • 67 citations

Connective tissue development in subcutaneously implanted polyvinyl sponge

1961 • 67 citations

The Source and State of the Hydroxylysine of Collagen

1959 • 66 citations

Conversion of Proline to Collagen Hydroxyproline^*

1966 • 65 citations

Relation between Urinary Hydroxyproline and Parathyroid Function*

1964 • 64 citations

The urinary excretion of free amino acids and other amino compounds by the human.

1959 • 60 citations

Amino acid transport by the small intestine of the rat The existence and specificity of the transport mechanism of imino acids and its relation to the transport of glycine

1966 • 59 citations

Value of Urine and Serum Hydroxyproline in the Diagnosis of Thyroid Disease

1965 • 58 citations

Metabolism of Collagen in Experimental Hyperthyroidism and Hypothyroidism in the Rat¹

1967 • 54 citations

Influence of Scurvy and Lathyrism (Odoratism) on Hydroxyproline Excretion

1961 • 54 citations

Clinical Significance of a Hydroxyproline-containing Protein in Human Plasma*

1965 • 54 citations

Hydroxylation of lysine in a polypeptide precursor of collagen

1966 • 52 citations

Influence of cortisol on the synthesis of sulfated mucopolysaccharides and collagen in chick embryos

1967 • 52 citations

STUDIES ON THE FORMATION OF COLLAGEN

1959 • 50 citations

Collagen biosynthesis the formation of hydroxyproline and soluble-ribonucleic acid complexes of proline and hydroxyproline by chick embryo in vivo and by a subcellular chick-embryo system

1963 • 50 citations

Use of Collagenase to Identify Enzymatically Formed Collagen and a Hydroxyproline-deficient Intermediate

1965 • 49 citations

Urinary Hydroxyproline and Calcium Metabolism in Patients with Cancer

1966 • 49 citations

Conversion of proline-C14 to peptide-bound hydroxyproline-C14 in a cell-free system from chick embryo

1961 • 49 citations

Improvements in methods for measuring hydroxyproline: application to human urine.

1959 • 48 citations

Collagen-Like Protein in Human Plasma

1963 • 46 citations

Hydroxylation of proline in particulate fractions from cartilage

1965 • 46 citations

Connective Tissue V. Comparison of Synthesis and Turnover of Collagen and Elastin in Tissues of Rat at Several Ages.

1961 • 44 citations

Ascorbic Acid and Collagen Fiber Formation

1961 • 44 citations

Collagen Degradation and the Response to Parathyroid Extract in the Intact Rhesus Monkey*

1967 • 44 citations

Skin and Femur Collagens and Urinary Hydroxyproline of Cortisone-Treated Rats

1965 • 43 citations

Urinary Hydroxyproline Excretion in Metastatic Cancer of Bone

1964 • 43 citations

Relationship Between Soluble Collagen and Urinary Hydroxyproline in the Lathyritic Rat.

1962 • 42 citations

Hydroxyproline and creatinine excretion in infantile protein malnutrition.

1965 • 41 citations

HYDROXYPROLINE-CONTAINING FRACTIONS IN NORMAL AND CORTISONE-TREATED CHICK EMBRYOS.

1963 • 40 citations

COLLAGEN METABOLISM IN OSTEOLATHYRISM IN CHICK EMBRYOS: SITE OF ACTION OF ß-AMINOPROPIONITRILE

1962 • 40 citations

Biochemistry of lathyrism

1962 • 40 citations

Experimental Lathyrism in the Rat. Nature of Defect in Epiphysial Cartilage

1958 • 39 citations

The size of the polypeptide precursor of collagen hydroxyproline.

1966 • 39 citations

Parathyroid Inhibition of Bone Collagen Synthesis

1964 • 39 citations

Isolation of hydroxylysyl-sRNA and hydroxyprolyl-sRNA in a chick embryo system

1963 • 38 citations

The influence of age and growth rate on the extractable collagen of skin of normal rats.

1962 • 38 citations

Metabolic studies of human bone in vitro. II. Changes in hyperparathyroidism.

1965 • 37 citations

Renal tubular transport of proline, hydroxyproline, and glycine. II. Hydroxy-l-proline as substrate and as inhibitor in vivo.

1966 • 36 citations

The Formation of Free Hydroxyproline by Rat Cartilage in Vitro

1962 • 36 citations

Further Evidence for the Accumulation of a Hydroxyproline-deficient, Collagenase-degradable Protein during Collagen Biosynthesis in Vitro

1966 • 36 citations

An Effect of Puromycin on the Synthesis of Collagen by Embryonic Cartilage in Vitro

1966 • 36 citations

Enzymatic Synthesis of Hydroxyproline by the Hydroxylation of Poly(L-prolyl-glycyl-L-prolyl)

1967 • 34 citations

Total urinary hydroxyproline excretion in normal human subjects.

1965 • 34 citations

Untersuchungen über den Stoffwechsel des Kollagens, II. Der Einbau von [¹⁴C]Glycin in Kollagen bei mit Prednison behandelten Ratten

1964 • 33 citations

Bestimmung von Oxyprolin. Zur Methode nach K. Lang.

1934 • 32 citations

The determination of hydroxyproline in urine

1965 • 32 citations

Hydroxyproline in the Serum and Urine of Patients with Hyperthyroidism

1964 • 31 citations

Urinary Hydroxyproline Excretion in Malabsorption States

1965 • 30 citations

Formation of s-RNA hydroxyproline in chick-embryo and wound granulation tissue

1964 • 28 citations

Urinary hydroxyproline excretion in normal subjects and in patients affected with primary diseases of bone

1965 • 28 citations

Urinary Excretion of Acid Mucopolysaccharides and Hydroxyproline in Psoriasis

1965 • 28 citations

Skeletal metabolism in early infancy: Urinary hydroxyproline

1966 • 27 citations

The Significance of Gelatin Tolerance in Malabsorptive States

1966 • 27 citations

Puromycin inhibition of collagen synthesis as evidence for a ribosomal or post-ribosomal site for the hydroxylation of proline

1964 • 26 citations

The role of free hydroxyproline in the biosynthesis of collagen☆

1965 • 26 citations

Urinary hydroxyproline during late pregnancy and postpartum involution

1964 • 26 citations

The relationship of parathyroid activity to pyrophosphate excretion.

1966 • 24 citations

Effect of Parathyroid Extract on Collagen Metabolism

1966 • 24 citations

Collagen fractions in lathyritic rats

1960 • 24 citations

Effect of Cortisone on the Hydroxyproline in the Serum and Urine of Young Rats

1965 • 23 citations

Cell-free collagen biosynthesis and the hydroxylation of sRNA-proline

1965 • 23 citations

URINARY HYDROXYPROLINE IN DISEASES INVOLVING BONE AND CALCIUM METABOLISM

1964 • 22 citations

Parathyroid-Induced Changes in Collagen and Calcium Metabolismin Vivo

1967 • 21 citations

Effect of Thyroxine on the Hydroxyproline in Rat Urine and Skin

1963 • 21 citations

Clinical significance of urinary hydroxyproline determinations in children.

1965 • 21 citations

Studies of collagen turnover in lathyritic rats

1962 • 21 citations

Alpha-Ketoglutaric Semialdehyde: A Metabolic Intermediate

1964 • 20 citations

Hydroxyproline Peptides of Urine in Arthritic Patients and Controls on a Collagen-Free Diet.

1962 • 19 citations

Studies on hydroxyproline excretion and corticosteroid-induced dwarfism: Treatment with human growth hormone

1966 • 19 citations

Urinary hydroxyproline in various diseases.

1965 • 18 citations

Observations on the Urinary Excretion of Amino Acids by the Premature Infant

1960 • 18 citations

Collagen breakdown in thermal burns.

1962 • 17 citations

Parathyroid hormone and urinary hydroxyproline

1965 • 17 citations

Elevated plasma levels of a hydroxyproline-containing protein in Hodgkin's disease and their relation to disease activity.

1966 • 17 citations

Urinary Hydroxyproline Excretion in Marian's Syndrome as Compared with Age Matched Controls.

1964 • 16 citations

Urinary hydroxyproline levels in an aged population a study of non‐osteoporotic and osteoporotic patients

1965 • 14 citations

Biochemistry of experimental lathyrism

1961 • 14 citations

Hydroxyprolinemia and Increased Excretion of Free Hydroxyproline in Early Infancy

1966 • 13 citations

EFFECT OF CORTISONE AND AGE ON THE HYDROXYPROLINE AND PROLINE CONCENTRATIONS OF BLOOD AND URINE IN THE RAT

1958 • 13 citations

Regulation of Hydroxyproline Excretion in Hyperparathyroidism

1966 • 13 citations

Primary Hyperparathyroidism—Evaluation of Diagnostic Aids: Calcium Infusion, Phosphorus Deprivation and Hydroxyprolinuria

1966 • 13 citations

Further Studies on the Action of Thyroid Hormones on the Metabolism of Collagen

1964 • 12 citations

Effect of Growth Hormone on Acetic Acid-Extractable Collagen of Hamster Skin

1958 • 12 citations

An oral gelatin-xylose test for estimating pancreatic proteolytic activity

1963 • 12 citations

Excretion of hydroxyproline in patients with sarcoidosis.

1966 • 12 citations

EFFECT OF GROWTH HORMONE AND OF AN ANABOLIC STEROID ON EXCRETION OF HYDROXYPROLINE IN THE URINE OF RATS

1965 • 11 citations

Étude d'une méthode d'exploration et du taux normal de l'hydroxyproline du sérum

1965 • 11 citations

Hydroxyproline in Human Blood: Forms in Which It Is Present.

1965 • 11 citations

A new glycopeptide containing hydroxyproline and sarcosine in human urine

1965 • 11 citations

The Amount of free Hydroxyproline in Human Blood Serum

1962 • 11 citations

Hydroxyproline Excretion in Urine of Patients with Muscular Dystrophy and Other Muscle Diseases.

1964 • 10 citations

Hydrocortisone and/or desiccated thyroid in physiologic dosage

1964 • 9 citations

CORRELATION OF URINARY HYDROXYPROLINE TO SEVERITY OF BURN.

1964 • 9 citations

Total urinary hydroxyproline excretion in diabetics before and after hypophysectomy and after growth hormone in adult hypopituitarism

1965 • 9 citations

In vitro Incorporation and Hydroxylation of Lysine-2-C14 In Rat Biopsy-Connective Tissue.

1958 • 9 citations

Urinary excretion of hydroxyproline in tropical sprue

1964 • 8 citations

Dynamics of changes in connective tissue components during development of carrageenan granuloma.

1961 • 8 citations

EFFECT OF GROWTH HORMONE AND OF PREGNANCY ON THE HYDROXYPROLINE CONCENTRATION OF THE BLOOD OF RATS

1958 • 5 citations

Biochemical studies on the collagen metabolism. 2. Collagen metabolism of the skin in some pathological states.

1960 • 3 citations