Insights into the complex association of bovine factor Va with acidic-lipid-containing synthetic membranes

A simple method for the preparation of homogeneous phospholipid vesicles

1977 • 861 citations

The role of phospholipids and factor Va in the prothrombinase complex.

1980 • 672 citations

The contribution of bovine Factor V and Factor Va to the activity of prothrombinase.

1979 • 592 citations

The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity.

1979 • 356 citations

Polyacrylamide gel electrophoresis in sodium dodecyl sulfate-containing buffers using multiphasic buffer systems: Properties of the stack, valid Rf− measurement, and optimized procedure

1977 • 307 citations

Binding of peptides with basic residues to membranes containing acidic phospholipids

1991 • 236 citations

Thrombin-catalyzed activation of single chain bovine factor V.

1979 • 229 citations

Phospholipid-binding properties of bovine factor V and factor Va

1979 • 173 citations

The interaction of bovine factor V and factor V-derived peptides with phospholipid vesicles.

1983 • 171 citations

The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex.

1987 • 170 citations

Observations on the interaction of phospholipids and certain clotting factors in prothrombin activator formation

1964 • 169 citations

Prothrombinase complex assembly. Kinetic mechanism of enzyme assembly on phospholipid vesicles.

1988 • 158 citations

Cofactor dependence of factor Xa incorporation into the prothrombinase complex.

1981 • 141 citations

[21] Factor V

1981 • 138 citations

Loss of prothrombin and of factor Xa-factor Va interactions upon inactivation of factor Va by activated protein C.

1984 • 133 citations

An experimental test of the discreteness-of-charge effect in positive and negative lipid bilayers

1986 • 127 citations

The binding of factor Va to phospholipid vesicles.

1988 • 125 citations

Cytochrome c induced lateral phase separation in a diphosphatidylglycerol-steroid spin-label model membrane

1976 • 112 citations

Structure of the prothrombin- and blood clotting factor X-membrane complexes

1977 • 108 citations

Extensive segregation of acidic phospholipids in membranes induced by protein kinase C and related proteins

1991 • 97 citations

Studies of the role of factor Va in the factor Xa-catalyzed activation of prothrombin, fragment 1.2-prethrombin-2, and dansyl-L-glutamyl-glycyl-L-arginine-meizothrombin in the absence of phospholipid.

1990 • 97 citations

Characterization of two forms of human factor Va with different cofactor activities.

1993 • 93 citations

The binding of activated protein C to factors V and Va.

1986 • 91 citations

A new model to describe extrinsic protein binding to phospholipid membranes of varying composition: application to human coagulation proteins

1989 • 87 citations

Nonideal mixing of phosphatidylserine and phosphatidylcholine in the fluid lamellar phase

1993 • 86 citations

Bilayer curvature and certain amphipaths promote poly(ethylene glycol)-induced fusion of dipalmitoylphosphatidylcholine unilamellar vesicles

1992 • 86 citations

Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles

1983 • 85 citations

The action of thrombin on blood clotting factor V: conversion of factor V to a prothrombin-binding protein

1973 • 79 citations

The Reassociation of Factor Va from Its Isolated Subunits

1989 • 77 citations

Proteolysis of factor Va by factor Xa and activated protein C.

1987 • 77 citations

Assembly of the Prothrombinase Complex on Lipid Vesicles Depends on the Stereochemical Configuration of the Polar Headgroup of Phosphatidylserine

1994 • 72 citations

The activation of prothrombin by the prothrombinase complex. The contribution of the substrate-membrane interaction to catalysis.

1994 • 72 citations

Phospholipid lateral organization in synthetic membranes as monitored by pyrene-labeled phospholipids: effects of temperature and prothrombin fragment 1 binding

1986 • 70 citations

Kinetic and hydrodynamic analysis of blood clotting factor V-membrane binding

1982 • 69 citations

Factor Va-membrane interaction is mediated by two regions located on the light chain of the cofactor

1994 • 56 citations

Identification and characterization of a phospholipid-binding site of bovine factor Va.

1990 • 50 citations

Specific contribution of different phospholipid surfaces to the activation of prothrombin by the fully assembled prothrombinase.

1993 • 49 citations

Evaluation of membrane phase behavior as a tool to detect extrinsic protein-induced domain formation: binding of prothrombin to phosphatidylserine/phosphatidylcholine vesicles

1990 • 48 citations

Preferential association of apocytochrome c with negatively charged phospholipids in mixed model membranes

1986 • 46 citations

Membrane binding properties of blood coagulation factor V and derived peptides

1984 • 46 citations

Calcium- and prothrombin-induced lateral phase separation in membranes

1981 • 46 citations

Comparison of the abilities of synthetic and platelet-derived membranes to enhance thrombin formation

1985 • 44 citations

Ca2+-Dependent Binding of Endonexin (Annexin IV) to Membranes: Analysis of the Effects of Membrane Lipid Composition and Development of a Predictive Model for the Binding Interaction

1994 • 43 citations

A domain of membrane-bound blood coagulation factor Va is located far from the phospholipid surface. A fluorescence energy transfer measurement

1986 • 40 citations

Phase behavior of mixed phosphatidylglycerol/phosphatidylcholine multilamellar and unilamellar vesicles

1982 • 38 citations

Binding of bovine factor Va to phosphatidylcholine membranes

1996 • 38 citations

Electrostatic and hydrophobic interactions are involved in factor Va binding to membranes containing acidic phospholipids.

1994 • 38 citations

Structure of membrane‐bound human factor Va

1994 • 35 citations

Interaction of blood coagulation factor Va with phospholipid vesicles. Examination using lipophilic photoreagents

1987 • 31 citations

Calcium-dependent and calcium-independent interactions of prothrombin fragment 1 with phosphatidylglycerol/phosphatidylcholine unilamellar vesicles

1985 • 26 citations

Membrane penetration of bovine factor V and Va detected by labeling with 5-iodonaphthalene-1-azide.

1987 • 25 citations

Electron microscopy and hydrodynamic properties of blood clotting factor V and activation fragments of factor V with phospholipid vesicles.

1984 • 25 citations

Fourier transform infrared spectroscopic study of Ca2+ and membrane-induced secondary structural changes in bovine prothrombin and prothrombin fragment 1

1991 • 23 citations

Membrane binding induces lipid-specific changes in the denaturation profile of bovine prothrombin. A scanning calorimetry study

1991 • 19 citations

Calcium-independent activation of prothrombin on membranes with positively charged lipids

1988 • 18 citations

The effect of factor Va on lipid dynamics in mixed phospholipid vesicles as detected by steady‐state and time‐resolved fluorescence depolarization of diphenylhexatriene

1987 • 4 citations