Radioimmunoassay evidence that the pressor effect of big endothelindash1 is due to local conversion to endothelindash1

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

1988 • 10,786 citations

Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788.

1994 • 574 citations

Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1

1990 • 158 citations

Inhibition of biological actions of big endothelin-1 by phosphoramidon

1990 • 146 citations

Phosphoramidon, a metalloproteinase inhibitor, suppresses the secretion of endothelin-1 from cultured endothelial cells by inhibiting a big endothelin-1 converting enzyme

1990 • 142 citations

Putative precursors of endothelin have less vasoconstrictor activity in vitro but a potent pressor effect in vivo

1989 • 126 citations

Incomplete inhibition of the pressor effects of endothelin‐1 and related peptides in the anaesthetized rat with BQ‐123 provides evidence for more than one vasoconstrictor receptor

1993 • 75 citations

Intravascular big endothelin increases circulating levels of endothelin-1 and prostanoids in the rabbit

1990 • 54 citations

Phosphoramidon inhibits the generation of endothelin‐1 from exogenously applied big endothelin‐1 in cultured vascular endothelial cells and smooth muscle cells

1991 • 49 citations

In Vivo Pharmacology of Ro 46-2005, The First Synthetic Nonpeptide Endothelin Receptor Antagonist: Implications for Endothelin Physiology

1993 • 46 citations

The effects of phosphoramidon on the regional haemodynamic responses to human proendothelin [1–38] in conscious rats

1991 • 42 citations

Phosphoramidon does not inhibit endogenous endothelin-1 release stimulated by hemorrhage, cytokines and hypoxia in rats

1994 • 38 citations

Phosphoramidon blocks big‐endothelin‐1 but not endothelin‐1 enhancement of vascular permeability in the rat

1992 • 36 citations

Effects of Phosphoramidon in Endothelial Cell Cultures on the Endogenous Synthesis of Endothelin-1 and on Conversion of Exogenous Big Endothelin-1 to Endothelin-1

1993 • 28 citations

In vivo characterization of a phosphoramidon-sensitive endothelin-converting enzyme in the rat

1993 • 27 citations

Endothelium-independent pressor effect of big endothelin-1 and its inhibition by phosphoramidon in rat mesenteric artery

1993 • 19 citations

Responses to endothelin-1, human proendothelin (1–38) and porcine proendothelin (1–39) in the rat on intravenous administration and in the blood perfused mesentery

1991 • 18 citations

Why Big Endothelin-1 Lacks a Vasodilator Response

1993 • 17 citations

Coeliac haemodynamic effects of endothelin‐1, endothelin‐3, proendothelin‐1 [1–38] and proendothelin‐3 [1–41] in conscious rats

1992 • 16 citations

Phosporamidon inhibits the vasoconstrictor effects evoked by big endothelin-1 but not the elevation of plasma endothelin-1 in vivo

1991 • 15 citations

Regional haemodynamic responses to intravenous and intraarterial endothelin‐1 and big endothelin‐1 in conscious rats

1993 • 13 citations

Big endothelin-1 and big endothelin-3 are constrictor agents in the microvasculature: evidence for the local phosphoramidon-sensitive conversion of big endothelin-1

1993 • 12 citations

Effect of the chronic administration of ethinyl estradiol and norgestrel on biogenic amine(s) level and monoamine oxidase enzyme activity in rat brain

1980 • 9 citations