Cell Cycle Regulation of Histone H1 Kinase Activity Associated with the Adenoviral Protein E1A

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product

1988 • 1,440 citations

Adenovirus early region 1A enables viral and cellular transforming genes to transform primary cells in culture

1983 • 1,358 citations

Monoclonal antibodies specific for simian virus 40 tumor antigens

1981 • 1,110 citations

Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2

1989 • 920 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Cellular targets for transformation by the adenovirus E1A proteins

1989 • 747 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

Human cyclin A is adenovirus E1A-associated protein p60 and behaves differently from cyclin B

1990 • 730 citations

Cyclin activation of p34cdc2

1990 • 690 citations

TGF-β1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains

1990 • 612 citations

The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation

1986 • 502 citations

Partial transformation of primary rat cells by the leftmost 4.5% fragment of adenovirus 5 DNA

1980 • 463 citations

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

1989 • 439 citations

Monoclonal antibodies specific for adenovirus early region 1A proteins: extensive heterogeneity in early region 1A products

1985 • 417 citations

p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.

1987 • 387 citations

Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28.

1985 • 370 citations

Multiple functional domains in the adenovirus E1A gene

1987 • 361 citations

Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+

1987 • 341 citations

An adenovirus E1a protein region required for transformation and transcriptional repression

1986 • 329 citations

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

1988 • 285 citations

Cell Cycle Control of DNA Replication by a Homologue from Human Cells of the p34 ^cdc2 Protein Kinase

1990 • 285 citations

A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells

1989 • 262 citations

Analysis of E1A-mediated growth regulation functions: binding of the 300-kilodalton cellular product correlates with E1A enhancer repression function and DNA synthesis-inducing activity

1990 • 251 citations

Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication

1989 • 242 citations

Two regions of the adenovirus early region 1A proteins are required for transformation

1988 • 232 citations

Identification of separate domains in the adenovirus E1A gene for immortalization activity and the activation of virus early genes.

1986 • 231 citations

Cloning by differential screening of a Xenopus cDNA coding for a protein highly homologous to cdc2.

1991 • 225 citations

The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function

1986 • 222 citations

cdc2 Gene Expression at the G ₁ to S Transition in Human T Lymphocytes

1990 • 220 citations

Retinoblastoma growth suppressor and a 300-kDa protein appear to regulate cellular DNA synthesis.

1990 • 209 citations

The Saccharomyces cerevisiae CKS1 gene, a homolog of the Schizosaccharomyces pombe suc1+ gene, encodes a subunit of the Cdc28 protein kinase complex.

1989 • 206 citations

[28] Quantitative two-dimensional gel electrophoresis of proteins

1983 • 188 citations

Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products.

1987 • 171 citations

In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes

1986 • 168 citations

A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products

1988 • 167 citations

Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe.

1987 • 158 citations

The release of growth arrest by microinjection of adenovirus E1A DNA.

1985 • 154 citations

Differential splicing yields novel adenovirus 5 E1A mRNAs that encode 30 kd and 35 kd proteins.

1987 • 142 citations

Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF

1987 • 124 citations

Adenovirus-induced alterations of the cell growth cycle: a requirement for expression of E1A but not of E1B

1983 • 120 citations

Human cyclin A and the retinoblastoma protein interact with similar but distinguishable sequences in the adenovirus E1A gene product.

1991 • 116 citations

E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products.

1991 • 102 citations

Expression of region E1b of human adenoviruses in the absence of region E1a is not sufficient for complete transformation

1983 • 100 citations

Interactions between cell growth-regulating domains in the products of the adenovirus E1A oncogene.

1988 • 88 citations

Use of N-chlorosuccinimide/urea for the selective cleavage of tryptophanyl peptide bonds in proteins. Cytochrome c.

1977 • 84 citations

Induction of cellular DNA synthesis by purified adenovirus E1A proteins

1986 • 75 citations