Mandelate Racemase: Structure-Function Studies of a Pseudosymmetric Enzyme

Synthesis of the Enzymes of the Mandelate Pathway by Pseudomonas putida I. Synthesis of Enzymes by the Wild Type

1966 • 399 citations

The evolution of α/β barrel enzymes

1990 • 378 citations

An explanation for rapid enzyme-catalyzed proton abstraction from carbon acids: importance of late transition states in concerted mechanisms

1993 • 370 citations

Understanding the rates of certain enzyme-catalyzed reactions: Proton abstraction from carbon acids, acyl transfer reactions, and displacement reactions of phosphodiesters

1993 • 352 citations

Active site titration and aminoacyl adenylate binding stoichiometry of aminoacyl-tRNA synthetases

1975 • 226 citations

pK of the lysine amino group at the active site of acetoacetate decarboxylase

1971 • 195 citations

Purification and mechanism of action of proline racemase

1968 • 173 citations

Electrophilic catalysis can explain the unexpected acidity of carbon acids in enzyme-catalyzed reactions

1991 • 166 citations

Suicide substrates for the alanine racemase of Escherichia coli B

1978 • 156 citations

Mandelate pathway of Pseudomonas putida: sequence relationships involving mandelate racemase, (S)-mandelate dehydrogenase, and benzoylformate decarboxylase and expression of benzoylformate decarboxylase in Escherichia coli

1990 • 156 citations

A Functionally Diverse Enzyme Superfamily that Abstracts the α Protons of Carboxylic Acids

1995 • 138 citations

Mechanism of the reaction catalyzed by mandelate racemase. 2. Crystal structure of mandelate racemase at 2.5-.ANG. resolution: identification of the active site and possible catalytic residues

1991 • 133 citations

Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous

1990 • 128 citations

The TIM barrel—the most frequently occurring folding motif in proteins

1991 • 118 citations

The role of lysine 166 in the mechanism of mandelate racemase from Pseudomonas putida: Mechanistic and crystallographic evidence for stereospecific alkylation by (R)-.alpha.-phenylglycidate

1994 • 108 citations

Mechanism of the reaction catalyzed by mandelate racemase: structure and mechanistic properties of the D270N mutant.

1996 • 101 citations

Isotope effects and the identification of catalytic residues in the reaction catalyzed by glutamate racemase

1993 • 99 citations

Mechanism of the reaction catalyzed by glutamate racemase

1993 • 95 citations

Proton exchange and mutarotation of chelated amino acids via carbanion intermediates

1967 • 81 citations

Crystal structure of muconate lactonizing enzyme at 3 Å resolution

1987 • 76 citations

The Enol of Mandelic Acid, Detection, Acidity in Aqueous Solution, and Estimation of the Keto-Enol Equilibrium Constant and Carbon Acidity of Mandelic Acid

1990 • 75 citations

Mechanism of the Reaction Catalyzed by Mandelate Racemase: Importance of Electrophilic Catalysis by Glutamic Acid 317

1995 • 70 citations

Mechanism of the reaction catalyzed by mandelate racemase. 3. Asymmetry in reactions catalyzed by the H297N mutant

1991 • 67 citations

Mandelic acid racemase from Pseudomonas putida. Purification and properties of the enzyme

1970 • 66 citations

Characteristics of .beta.,.beta.-difluoroalanine and .beta.,.beta.,.beta.-trifluoroalanine as suicide substrates for E. coli B alanine racemase

1981 • 64 citations

Mechanism of the reaction catalyzed by mandelate racemase. 1. Chemical and kinetic evidence for a two-base mechanism

1991 • 63 citations

THE ENZYMATIC CONVERSION OF MANDELIC ACID TO BENZOIC ACID I

1953 • 58 citations

The Active Site of Acetoacetate Decarboxylase¹

1966 • 45 citations

Mandelate racemase from Pseudomonas putida. Subunit composition and absolute divalent metal ion requirement

1974 • 44 citations

Mandelic acid racemase from Pseudomonas putida. Evidence favoring a carbanion intermediate in the mechanism of action

1970 • 43 citations

Mandelate racemase and class-related enzymes

1992 • 35 citations

Evidence for the generation of .alpha.-carboxy-.alpha.-hydroxy-p-xylylene from p-(bromomethyl)mandelate by mandelate racemase

1988 • 32 citations

A birect kinetic assay for mandelate racemase using circular dichroic measurements

1979 • 31 citations

Cloning, DNA sequence analysis, and expression in Escherichia coli of the gene for mandelate racemase from Pseudomonas putida

1988 • 30 citations

Symmetry and asymmetry in mandelate racemase catalysis

1985 • 30 citations

Carbon-13 nuclear magnetic resonance studies of mandelate metabolism in whole bacterial cells and in isolated, in vivo cross-linked enzyme complexes

1981 • 24 citations

Mandelate racemase from Pseudomonas putida. Affinity labeling of the enzyme by D, L-α-phenylglycidate in the presence of magnesium ion

1974 • 23 citations

Selection and characterization of a mutant of the cloned gene for mandelate racemase that confers resistance to an affinity label by greatly enhanced production of enzyme

1989 • 20 citations

Mechanism-based inactivation of mandelate racemase by propargylglycolate

1992 • 14 citations

Preliminary x-ray data on crystals of mandelate racemase.

1988 • 13 citations

Mandelate racemase from Pseudomonas putida. Absence of detectable intermolecular proton transfer accompanying racemization

1977 • 11 citations

[62] Mandelate racemase

1977 • 5 citations