Age and Relative Adiposity Are Specific Negative Determinants of the Frequency and Amplitude of Growth Hormone (GH) Secretory Bursts and the Half-Life of Endogenous GH in Healthy Men*

Abdominal adipose tissue distribution, obesity, and risk of cardiovascular disease and death: 13 year follow up of participants in the study of men born in 1913.

1984 • 1,948 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.

1983 • 1,455 citations

The Effects of Treatment with Recombinant Human Growth Hormone on Body Composition and Metabolism in Adults with Growth Hormone Deficiency

1989 • 1,411 citations

Effects of Sex and Age on the 24-Hour Profile of Growth Hormone Secretion in Man: Importance of Endogenous Estradiol Concentrations*

1987 • 927 citations

BENEFICIAL EFFECTS OF GROWTH HORMONE TREATMENT IN GH-DEFICIENT ADULTS

1989 • 894 citations

Impaired growth hormone secretion in the adult population: relation to age and adiposity.

1981 • 643 citations

Age-Related Change in the Twenty-Four Hour Spontaneous Secretion of Growth Hormone

1972 • 640 citations

The Influence of Age on the 24-Hour Integrated Concentration of Growth Hormone in Normal Individuals*

1985 • 600 citations

The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations.

1987 • 561 citations

Patterns of Growth Hormone-Eeleasing Factor and Somatostatin Secretion into the Hypophysial-Portal Circulation of the Rat

1985 • 534 citations

Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man.

1988 • 486 citations

Dual Defects in Pulsatile Growth Hormone Secretion and Clearance Subserve the Hyposomatotropism of Obesity in Man*

1991 • 481 citations

Effects of Estrogen and Sex Difference on Secretion of Human Growth Hormone1

1965 • 469 citations

Impaired Growth Hormone Responses to Growth Hormone–Releasing Factor in Obesity

1984 • 420 citations

Effects of Short Term Administration of Recombinant Human Growth Hormone to Elderly People*

1990 • 375 citations

Identification and characterization of specific binding proteins for growth hormone in normal human sera.

1986 • 313 citations

Augmentation of Growth Hormone Secretion during Puberty: Evidence for a Pulse Amplitude-Modulated Phenomenon*

1987 • 298 citations

Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: relationship to age, pubertal status, and body mass.

1992 • 259 citations

AGE-RELATED CHANGES IN PLASMA GROWTH HORMONE RESPONSE TO GROWTH HORMONE-RELEASING FACTOR IN MAN

1984 • 232 citations

Somatomedin-C Levels in Healthy Young and Old Men: Relationship to Peak and 24-Hour Integrated Levels of Growth Hormone

1985 • 205 citations

Free Fatty Acids Block Growth Hormone (GH) Releasing Hormone-Stimulated GH Secretion in Man Directly at the Pituitary*

1987 • 205 citations

Basal Plasma Growth Hormone Levels in Man: New Evidence for Rhythmicity of Growth Hormone Secretion*

1990 • 193 citations

Total human body protein synthesis in relation to protein requirements at various ages

1975 • 188 citations

Alterations in the Pulsatile Mode of Growth Hormone Release in Men and Women with Insulin-Dependent Diabetes Mellitus*

1989 • 166 citations

Absence of Sleep-Related Growth Hormone Peaks in Aged Normal Subjects and in Acromegaly

1972 • 163 citations

Antiserum to Somatostatin Reverses Starvation-Induced Inhibition of Growth Hormone but Not Insulin Secretion*

1978 • 163 citations

Growth Hormone (GH) Responsiveness to Combined Administration of Arginine and GH-Releasing Hormone Does not Vary with Age in Man*

1990 • 162 citations

Half-Time of Endogenous Growth Hormone (GH) Disappearance in Normal Man After Stimulation of GH Secretion by GH-Releasing Hormone and Suppression with Somatostatin*

1989 • 148 citations

Increased hGH Production Rate after Low-Dose Estrogen Therapy in Prepubertal Girls with Turner's Syndrome

1990 • 129 citations

Effects of Insulin on Rat Anterior Pituitary Cells: Inhibition of Growth Hormone Secretion and mRNA Levels

1986 • 118 citations

Cholinergic Receptor Activation by Pyridostigmine Restores Growth Hormone (GH) Responsiveness to GH Releasing Hormone Administration in Obese Subjects: Evidence for Hypothalamic Somatostatinergic Participation in the Blunted GH Release of Obesity*

1989 • 111 citations

Effect of Age on Growth Hormone Secretion in Man

1973 • 97 citations

Reduced growth hormone releasing factor (GHRF)-like immunoreactivity and GHRF gene expression in the hypothalamus of aged rats

1989 • 96 citations

Growth Hormone Restores Protein Synthesis in Skeletal Muscle of Old Male Rats

1985 • 88 citations

Integrated concentrations of growth hormone, insulin, C-peptide and prolactin in human obesity

1982 • 65 citations

Impact of intensive venous sampling on characterization of pulsatile GH release

1987 • 58 citations

Differential Effects of Feeding on the Ultradian Variation of the Growth Hormone (GH) Response to GHReleasing Hormone in Normal Subjects and Patients With Obesity and Anorexia Nervosa

1988 • 56 citations

Increased Pituitary Response to Somatostatin in Aging Male Rats: Relationship to Somatostatin Receptor Number and Affinity

1989 • 46 citations

Metabolic Clearance Rates of Synthetic Human Growth Hormone in Lean and Obese Male Rhesus Monkeys*

1988 • 43 citations

Biophysical modeling of sensitivity and positive accuracy of detecting episodic endocrine signals

1989 • 34 citations

Effect of L-Dopa on Growth Hormone, Glucose, Insulin, and Cortisol Response in Obese Subjects

2009 • 30 citations

THE RESPONSE OF OBESE SUBJECTS TO CONTINUOUS INFUSION OF HUMAN PANCREATIC GROWTH HORMONE‐RELEASING FACTOR 1–44

1985 • 29 citations

A rapid and simple assay for growth hormone-binding protein activity in human plasma

1988 • 21 citations

Effect of Fenfluramine on Growth Hormone and Prolactin Secretion in Obese Subjects

1987 • 19 citations

Plasma Growth Hormone Response to Oral Clonidine as Compared to Insulin Hypoglycemia in Obese Children and Adolescents

2008 • 19 citations

Naloxone increases the response of growth hormone and prolactin to stimuli in obese humans

1987 • 17 citations

Changes in Basal and Stimulated Growth Hormone Secretion in the Aging Rhesus Monkey: A Comparison of Chair Restraint and Tether and Vest Sampling*

1990 • 16 citations