Modulation of immunity and inflammatory gene expression in the gut, in inflammatory diseases of the gut and in the liver by probiotics

Changes of Intestinal Functions in Liver Cirrhosis

2016 • 6,567 citations

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

2009 • 2,301 citations

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease

2009 • 1,283 citations

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

2008 • 1,062 citations

Probiotic Mechanisms of Action

2012 • 1,042 citations

The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects

2007 • 976 citations

The Role of the Gut Microbiota in Energy Metabolism and Metabolic Disease

2009 • 892 citations

Probiotics inhibit enteropathogenicE. coliadherence in vitro by inducing intestinal mucin gene expression

1999 • 820 citations

Synbiotic therapy (Bifidobacterium longum/Synergy 1) initiates resolution of inflammation in patients with active ulcerative colitis: a randomised controlled pilot trial

2005 • 719 citations

Antibiotics prevent liver injury in rats following long-term exposure to ethanol

1995 • 698 citations

Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals

2002 • 507 citations

Probiotics and immunity

2009 • 492 citations

Probiotics

2010 • 420 citations

Lactobacillus plantarum MB452 enhances the function of the intestinal barrier by increasing the expression levels of genes involved in tight junction formation

2010 • 410 citations

Nonalcoholic Fatty Liver Disease in Humans Is Associated with Increased Plasma Endotoxin and Plasminogen Activator Inhibitor 1 Concentrations and with Fructose Intake

2008 • 398 citations

Functional modulation of enterocytes by gram-positive and gram-negative microorganisms

2004 • 394 citations

Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition

2011 • 385 citations

Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota

2009 • 359 citations

Elevated endotoxin levels in non-alcoholic fatty liver disease

2010 • 353 citations

Human mucosal in vivo transcriptome responses to three lactobacilli indicate how probiotics may modulate human cellular pathways

2010 • 327 citations

Modulation of intestinal morphology and immunity in nile tilapia (Oreochromis niloticus) by Lactobacillus rhamnosus GG

2011 • 321 citations

Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model

2012 • 320 citations

Efficacy of probiotic use in acute diarrhea in children: a meta-analysis.

2002 • 320 citations

Sources, isolation, characterisation and evaluation of probiotics

2013 • 307 citations

Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius

2006 • 284 citations

Human CD4+ T Lymphocytes with Remarkable Regulatory Functions on Dendritic Cells and Nickel-Specific Th1 Immune Responses

2000 • 241 citations

Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production

2011 • 239 citations

Kupffer cell activation is a causal factor for hepatic insulin resistance

2009 • 235 citations

The Impact of Probiotic on Gut Health

2009 • 233 citations

Susceptibility to gut leakiness: a possible mechanism for endotoxaemia in non‐alcoholic steatohepatitis

2008 • 218 citations

Bacterial Probiotic Modulation of Dendritic Cells

2004 • 218 citations

Expression of immune-related genes in rainbow trout (Oncorhynchus mykiss) induced by probiotic bacteria during Lactococcus garvieae infection

2011 • 216 citations

Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-κB activation

2006 • 173 citations

Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells

2008 • 160 citations

Anti-Inflammatory Lactobacillus rhamnosus CNCM I-3690 Strain Protects against Oxidative Stress and Increases Lifespan in Caenorhabditis elegans

2012 • 157 citations

Lactobacillus acidophilus induces virus immune defence genes in murine dendritic cells by a Toll‐like receptor‐2‐dependent mechanism

2010 • 148 citations

Role of Toll-like receptors in the development of immunotolerance mediated by probiotics

2010 • 145 citations

Lactobacillus rhamnosus alleviates intestinal barrier dysfunction in part by increasing expression of zonula occludens-1 and myosin light-chain kinase in vivo

2009 • 130 citations

Saccharomyces cerevisiae Modulates Immune Gene Expressions and Inhibits ETEC-Mediated ERK1/2 and p38 Signaling Pathways in Intestinal Epithelial Cells

2011 • 127 citations

Specific probiotics alleviate allergic rhinitis during the birch pollen season

2009 • 122 citations

Innate mechanisms for Bifidobacterium lactis to activate transient pro‐inflammatory host responses in intestinal epithelial cells after the colonization of germ‐free rats

2005 • 120 citations

Role of Natural Killer and Dendritic Cell Crosstalk in Immunomodulation by Commensal Bacteria Probiotics

2011 • 118 citations

The Probiotic Lactobacillus GG may Augment Intestinal Host Defense by Regulating Apoptosis and Promoting Cytoprotective Responses in the Developing Murine Gut

2008 • 113 citations

Effect of natural commensal-origin DNA on toll-like receptor 9 (TLR9) signaling cascade, chemokine IL-8 expression, and barrier integritiy of polarized intestinal epithelial cells

2009 • 112 citations

Immunoregulatory Mechanisms Underlying Prevention of Colitis-Associated Colorectal Cancer by Probiotic Bacteria

2012 • 112 citations

Dose-Dependent Immunomodulation of Human Dendritic Cells by the Probiotic Lactobacillus rhamnosus Lcr35

2011 • 109 citations

Critical role of Kupffer cells in the management of diet-induced diabetes and obesity

2009 • 105 citations

Cell-Free Culture Supernatant of Bifidobacterium breve CNCM I-4035 Decreases Pro-Inflammatory Cytokines in Human Dendritic Cells Challenged with Salmonella typhi through TLR Activation

2013 • 103 citations

Epigenetic imprinting by commensal probiotics inhibits the IL-23/IL-17 axis in an in vitro model of the intestinal mucosal immune system

2012 • 102 citations

Immunoregulatory Effect of Bifidobacteria Strains in Porcine Intestinal Epithelial Cells through Modulation of Ubiquitin-Editing Enzyme A20 Expression

2013 • 101 citations

In vitro screening of probiotics and synbiotics according to anti-inflammatory and anti-proliferative effects

2010 • 101 citations

Anti-inflammatory and immunomodulatory efficacy of indigenous probiotic Lactobacillus plantarum Lp91 in colitis mouse model

2011 • 101 citations

Novel Evidence for Chronic Exposure to Endotoxin in Human Nonalcoholic Steatohepatitis

2010 • 100 citations

Impact of lipoteichoic acid modification on the performance of the probiotic Lactobacillus rhamnosus GG in experimental colitis

2010 • 99 citations

Probiotics VSL#3 Protect against Development of Visceral Pain in Murine Model of Irritable Bowel Syndrome

2013 • 98 citations

Immunostimulatory activity ofBacillusspores

2008 • 90 citations

Lactococcus lactis subsp. cremoris FC alleviates symptoms of colitis induced by dextran sulfate sodium in mice

2009 • 81 citations

In vitro evaluation of Lactobacillus plantarum DSMZ 12028 as a probiotic: Emphasis on innate immunity

2009 • 81 citations

Human Intestinal Dendritic Cells Decrease Cytokine Release against Salmonella Infection in the Presence of Lactobacillus paracasei upon TLR Activation

2012 • 77 citations

Probiotic Therapy in the Prevention of Pouchitis Onset: Decreased Interleukin-1β, Interleukin-8, and Interferon-γ Gene Expression

2005 • 75 citations

Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells

2008 • 75 citations

Effect of the combined probiotics with aflatoxin B1-degrading enzyme on aflatoxin detoxification, broiler production performance and hepatic enzyme gene expression

2013 • 74 citations

Anti‐inflammatory effects of the genus Bifidobacterium on macrophages by modification of phospho‐IκB and SOCS gene expression

2009 • 74 citations

ProbioticLactobacillus rhamnosusdownregulatesFCER1andHRH4expression in human mast cells

2011 • 72 citations

Probiotic Yeast Inhibits VEGFR Signaling and Angiogenesis in Intestinal Inflammation

2013 • 69 citations

An evaluation of the effects of Lactobacillus ingluviei on body weight, the intestinal microbiome and metabolism in mice

2011 • 67 citations

Effects of Probiotics, Prebiotics, and Synbiotics on Messenger RNA Expression of Caveolin-1, NOS, and Genes Regulating Oxidative Stress in the Terminal Ileum of Formula-Fed Neonatal Rats

2010 • 64 citations

Modulation of the immune response by probiotic strains in a mouse model of gluten sensitivity

2009 • 64 citations

Early administration of probioticLactobacillus acidophilusand/or prebiotic inulin attenuates pathogen-mediated intestinal inflammation and Smad 7 cell signaling

2012 • 61 citations

The association of minocycline and the probiotic Escherichia coli Nissle 1917 results in an additive beneficial effect in a DSS model of reactivated colitis in mice

2011 • 60 citations

Lactobacillus casei Zhang modulate cytokine and Toll‐like receptor expression and beneficially regulate poly I:C‐induced immune responses in RAW264.7 macrophages

2013 • 60 citations

Co-administration of Bacillus subtilis RJGP16 and Lactobacillus salivarius B1 strongly enhances the intestinal mucosal immunity of piglets

2012 • 57 citations

The host response to the probiotic Escherichia coli strain Nissle 1917: Specific up-regulation of the proinflammatory chemokine MCP-1

2005 • 57 citations

Metabolites of Lactobacillus plantarum 2142 Prevent Oxidative Stress-Induced Overexpression of Proinflammatory Cytokines in IPEC-J2 Cell Line

2012 • 54 citations

Clostridium butyricum activates TLR2-mediated MyD88-independent signaling pathway in HT-29 cells

2011 • 54 citations

Regulation of TLR4, p38 MAPkinase, IκB and miRNAs by inactivated strains of lactobacilli in human dendritic cells

2012 • 54 citations

Lactobacillus rhamnosus (LGG) Regulates IL-10 Signaling in the Developing Murine Colon through Upregulation of the IL-10R2 Receptor Subunit

2012 • 52 citations

Lactococcus lactis subsp. cremoris FC triggers IFN-γ production from NK and T cells via IL-12 and IL-18

2012 • 52 citations

Effect of Bifidobacterium bifidum BF-1 on gastric protection and mucin production in an acute gastric injury rat model

2012 • 49 citations

Lactobacillus rhamnosus GGandStreptococcus thermophilusinduce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages

2011 • 48 citations

Effect of fructo-oligosaccharides and different doses of Bifidobacterium animalis in a weaning diet on bacterial translocation and Toll-like receptor gene expression in pigs

2008 • 45 citations

Probiotic genomic DNA reduces the production of pro-inflammatory cytokine tumor necrosis factor-alpha

2011 • 45 citations

Therapeutic implications of manipulating and mining the microbiota

2009 • 45 citations

Pulse Probiotic Administration Induces Repeated Small Intestinal Muc3 Expression in Rats

2010 • 44 citations

Multistep mechanism of probiotic bacterium, the effect on innate immune system

2009 • 43 citations

Gene Expression Profiles Identify Inflammatory Signatures in Dendritic Cells

2010 • 42 citations

Clostridium butyricum TO-A Culture Supernatant Downregulates TLR4 in Human Colonic Epithelial Cells

2007 • 42 citations

Lysozyme-Modified Probiotic Components Protect Rats against Polymicrobial Sepsis: Role of Macrophages and Cathelicidin-Related Innate Immunity

2006 • 42 citations

Saccharomyces boulardii and Bacillus subtilis B10 Modulate TLRs Mediated Signaling to Induce Immunity by Chicken BMDCs

2013 • 41 citations

Effects of Bifidobacterium breve on inflammatory gene expression in neonatal and weaning rat intestine

2011 • 39 citations

Lactobacillus rhamnosus GG and Bifidobacterium animalis MB5 Induce Intestinal but Not Systemic Antigen-Specific Hyporesponsiveness in Ovalbumin-Immunized Rats

2012 • 37 citations

Bacillus clausii effect on gene expression pattern in small bowel mucosa using DNA microarray analysis

2005 • 36 citations

Effects of Live and Inactivated VSL#3 Probiotic Preparations in the Modulation of in vitro and in vivo Allergen-Induced Th2 Responses

2009 • 34 citations

Adhesion and immunomodulatory effects ofBifidobacterium lactisHN019 on intestinal epithelial cells INT-407

2010 • 33 citations

Symbiotic formulation in experimentally induced liver fibrosis in rats: intestinal microbiota as a key point to treat liver damage?

2013 • 30 citations

Gene Expression Profiling Identifies Mechanisms of Protection to Recurrent Trinitrobenzene Sulfonic Acid Colitis Mediated by Probiotics

2011 • 28 citations

Inulin and probiotics in newly weaned piglets: effects on intestinal morphology, mRNA expression levels of inflammatory marker genes and haematology

2010 • 26 citations

Transcriptomic response of immune signalling pathways in intestinal epithelial cells exposed to lipopolysaccharides, Gram-negative bacteria or potentially probiotic microbes

2012 • 25 citations

Preventive and curative effects of probiotics in atopic patients

2005 • 25 citations

Prebiotics, Probiotics and Helminths: The ‘Natural’ Solution?

2009 • 23 citations

The contribution of gut-derived endotoxins to liver injury.

1979 • 22 citations

Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus

2012 • 20 citations

A plasmacytoid dendritic cell (CD123+/CD11c−) based assay system to predict contact allergenicity of chemicals

2009 • 18 citations

Modulation of cytokine gene expression in spleen and Peyer's patches by feeding dahi containing probiotic Lactobacillus casei in mice

2009 • 16 citations

Bifidobacterium breve – HT-29 cell line interaction: modulation of TNF-α induced gene expression

2011 • 16 citations