Catecholamines and Neurologic Diseases

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

Tyrosine Hydroxylase

1964 • 2,038 citations

Verteilung Von Noradrenalin Und Dopamin (3-Hydroxytyramin) Im Gehirn Des Menschen Und Ihr Verhalten Bei Erkrankungen Des Extrapyramidalen Systems

1960 • 1,863 citations

Aromatic Amino Acids and Modification of Parkinsonism

1967 • 1,464 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Enzymatic O-Methylation of Epinephrine and Other Catechols

1958 • 1,291 citations

Modification of Parkinsonism — Chronic Treatment with L-Dopa

1969 • 1,253 citations

Immunohistochemical evidence for the existence of adrenaline neurons in the rat brain

1974 • 1,097 citations

The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs

1954 • 1,014 citations

Huntington's Chorea

1973 • 845 citations

On the Presence of 3-Hydroxytyramine in Brain

1958 • 632 citations

HUNTINGTON'S CHOREA

1974 • 527 citations

[The L-3,4-dioxyphenylalanine (DOPA)-effect in Parkinson-akinesia].

1961 • 515 citations

The Pharmacology of Tardive Dyskinesias

1973 • 512 citations

THE DISTRIBUTION OF DOPAMINE AND DOPA IN VARIOUS ANIMALS AND A METHOD FOR THEIR DETERMINATION IN DIVERSE BIOLOGICAL MATERIAL.

1964 • 500 citations

The Use of Dopamine β-Hydroxylase as a Marker for the Central Noradrenergic Nervous System in Rat Brain

1972 • 416 citations

Brain Catechol Synthesis: Control by Brain Tyrosine Concentration

1974 • 367 citations

Role of brain norepinephrine in audiogenic seizure in the rat.

1973 • 363 citations

INFLUENCE OF THE SUBSTANTIA NIGRA ON THE CATECHOLAMINE CONTENT OF THE STRIATUM

1965 • 340 citations

L-Dopa-Induced Release of Cerebral Monoamines

1970 • 327 citations

Serum Dopamine-Beta-Hydroxylase Activity

1971 • 327 citations

DOPAMINE IN THE BASAL GANGLIA: Its Role and Therapeutic Implications (Including the Clinical Use of L-DOPA)

1973 • 316 citations

Plasma amino acids in patients with hepatic encephalopathy

1974 • 303 citations

An experimental model of tardive dyskinesia

1972 • 276 citations

Substrate specificity of steady-state amino acid transport in mouse brain slices

1965 • 263 citations

Central monoamines and convulsive thresholds in mice and rats

1973 • 260 citations

Histochemical demonstration and mapping of 5-hydroxytryptamine- and catecholamine-containing neuron systems in the human fetal brain

1973 • 258 citations

Tardive Dyskinesia in Patients Treated with Major Neuroleptics: A Review of the Literature

1968 • 235 citations

Lack of Uptake of Catecholamines after Chronic Denervation of Sympathetic Nerves

1961 • 231 citations

Regulation of Norepinephrine Biosynthesis

1970 • 231 citations

INSULIN, PLASMA AMINOACID IMBALANCE, AND HEPATIC COMA

1975 • 224 citations

The effects of high phenylalanine concentrations on serotinin and catecholamine metabolism in the human brain

1972 • 223 citations

Adrenal Tyrosine Hydroxylase: Compensatory Increase in Activity after Chemical Sympathectomy

1969 • 206 citations

False Adrenergic Transmitters

1968 • 197 citations

Modification of Chronic Manganese Poisoning

1970 • 195 citations

Monoamine metabolites in lumbar CSF: The question of their origin in relation to clinical studies

1974 • 189 citations

Choline acetylase and glutamic acid decarboxylase in Huntington's chorea

1973 • 180 citations

Pharmaco-histochemical evidence of the existence of dopamine nerve terminals in the limbic cortex

1974 • 173 citations

REDUCED GLUTAMIC-ACID- DECARBOXYLASE ACTIVITY OF POST-MORTEM BRAIN IN HUNTINGTON'S CHOREA

1973 • 168 citations

Role of Central and Peripheral Adrenergic Mechanisms in Neurogenic Hypertension Produced by Brainstem Lesions in Rat

1974 • 163 citations

HOMOVANILLIC ACID AND 5‐HYDROXYINDOLEACETIC ACID IN THE CEREBROSPINAL FLUID OF PATIENTS WITH SENILE DEMENTIA, PRESENILE DEMENTIA AND PARKINSONISM

1969 • 160 citations

Reduced Plasma Dopamine-β-Hydroxylase Activity in Familial Dysautonomia

1971 • 158 citations

The inactivation of adrenaline

1937 • 149 citations

A Pharmacologic Analysis of Huntington’s Chorea

1970 • 146 citations

Participation of Central Noradrenergic Neurons in Arterial Baroreceptor Reflexes in the Rabbit

1971 • 145 citations

Dopamine and Serotonin Metabolism in Hepatic Encephalopathy

1974 • 144 citations

Treatment of Tardive Dyskinesia

1972 • 140 citations

Adrenocortical control of the biosynthesis of epinephrine and proteins in the adrenal medulla.

1972 • 137 citations

Protein Intake and Treatment of Parkinson's Disease with Levodopa

1975 • 136 citations

Amine metabolism in the human brain: Further evaluation of the probenecid test

1971 • 135 citations

Concentrations of 5-Hydroxyindole-acetic Acid and Homovanillic Acid in the Cerebrospinal Fluid after Treatment with Probenecid in Patients with Parkinson's Disease

1968 • 135 citations

The metabolism of orally administered <scp>l</scp>‐DOPA in Parkinsonism

1969 • 135 citations

p -Chlorophenylalanine-Induced Chemical Manifestations of Phenylketonuria in Rats

1967 • 131 citations

Treatment of Gilles de la Tourette's Syndrome with Haloperidol

1968 • 130 citations

Reduction in Brain Dopamine following Experimental Cerebral Ischaemia

1974 • 126 citations

An assay for dopamine-β-hydroxylase activity in tissues and serum

1971 • 126 citations

The Investigation of Homovanillic Acid in the Human Brain and its Correlation to Senile Dementia

1969 • 125 citations

Biogenic amine concentrations in traumatized spinal cords of cats

1974 • 123 citations

Catecholamines in Experimental Brain Ischemia

1975 • 120 citations

Levodopa in Parkinsonism: Potentiation of Central Effects with a Peripheral Inhibitor

1972 • 119 citations

Amine Metabolites in Human Cerebrospinal Fluid: Effects of Cord Transection and Spinal Fluid Block

1973 • 117 citations

NOREPINEPHRINE METABOLISM IN THE CENTRAL NERVOUS SYSTEM OF MAN: STUDIES USING 3‐METHOXY‐4‐HYDROXYPHENYLETHYLENE GLYCOL LEVELS IN CEREBROSPINAL FLUID

1973 • 114 citations

THEORETICAL IMPLICATIONS OF THE USE OF L-DOPA IN PARKINSONISM.

1970 • 110 citations

Brain H ³ ‐catecholamine metabolism in experimental cerebral ischemia

1975 • 110 citations

STUDIES OF AMINES IN THE STRIATUM IN MONKEYS WITH NIGRAL LESIONS

1969 • 110 citations

Treatment of Tardive Dyskinesia

1972 • 110 citations

Monoamine neurotransmitters and the pathophysiology of stroke and central nervous system trauma

1974 • 110 citations

Uptake and efflux of ¹⁴ C‐dopamine in platelets

1975 • 107 citations

Use of L-Dopa in the Detection of Presymptomatic Huntington's Chorea

1972 • 102 citations

Metabolic fate of L-[14C] DOPA in cerebrospinal fluid and blood plasma of humans

1967 • 101 citations

Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid

1973 • 101 citations

DISORDERED NEUROTRANSMITTER FUNCTION

1974 • 100 citations

Effects of L-Dopa on Norepinephrine Metabolism in the Brain

1971 • 97 citations

5-Hydroxyindoleacetic Acid and Homovanillic Acid in Cerebrospinal Fluid of Patients with Neurological Diseases

1974 • 93 citations

LEVODOPA IN HEPATIC COMA

1970 • 92 citations

On the origin of homovanillic acid in the cerebrospinal fluid

1966 • 89 citations

Acid monoamine metabolites in cerebrospinal fluid in multiple sclerosis

1973 • 87 citations

Abnormal Catechol Amine Metabolism in Familial Dysautonomia

1963 • 87 citations

The concentration of homovanillic and 5‐hydroxyindoleacetic acids in ventricular and lumbar CSF

1972 • 86 citations

Rat brain regional uptake and decarboxylation of L-DOPA following carotid injection

1975 • 86 citations

Role of a false neurotransmitter, octopamine, in the pathogenesis of hepatic and renal encephalopathy.

1973 • 85 citations

L-Dopa (L-3,4-dihydroxyphenylanine)--its clinical effects in parkinsonism.

1968 • 85 citations

The biosynthesis of octopamine

1972 • 83 citations

Reduced cerebrospinal fluid 5‐hydroxyindoleacetic acid and homovanillic acid in children with epilepsy

1975 • 83 citations

Reserpine-induced alterations in brain amines and their relationship to changes in the incidence of minimal electroshock seizures in mice.

1972 • 83 citations

Apomorphine in huntington's chorea: Clinical observations and theoretical considerations

1974 • 82 citations

Amine Metabolites in the Lumbar Cerebrospinal Fluid of Humans with Restricted Flow of Cerebrospinal Fluid

1971 • 82 citations

Serum dopamine β-hydroxylase as an index of sympathetic function

1974 • 81 citations

Presynaptic Catecholamine Antagonists as Treatment for Tourette Syndrome

1974 • 78 citations

Elevated Plasma Dopamine-β-Hydroxylase Activity in Autosomal Dominant Torsion Dystonia

1973 • 78 citations

Folie acid deficiency and methyl group metabolism in rat brain: Effects of l-dopa

1974 • 77 citations

Studies in experimental spinal cord trauma

1974 • 76 citations

Neurological features of Gilles de la Tourette's syndrome

1973 • 73 citations

Treatment of hepatic coma and hepatorenal syndrome

1972 • 71 citations

BRAIN-DECARBOXYLASE ACTIVITIES AS INDICES OF PATHOLOGICAL CHANGE IN SENILE DEMENTIA

1974 • 71 citations

Pyridoxine reversal of L-dopa effects in Parkinsonism.

1969 • 70 citations

Urinary Monoamine Metabolites in Children with Minimal Brain Dysfunction

1971 • 70 citations

Effect of Ischemia on Monoamine Metabolism in the Brain

1974 • 70 citations

Amine metabolites in the cerebrospinal fluid of patients with disseminated sclerosis

1974 • 66 citations

The role of biogenic amines in the reserpine-induced alteration of minimal electroshock seizure thresholds in the mouse

1973 • 65 citations

Noradrenergic neurons: Allosteric activation of hippocampal tyrosine hydroxylase by stimulation of the locus coeruleus

1974 • 64 citations

Resynthesis of Catecliol Hormones in the Cat's Adrenal Medulla

1958 • 61 citations

Parkinson's Disease, Cerebral Arteriosclerosis, and Senile Dementia&lt;subtitle&gt;CLINICAL FEATURES AND RESPONSE TO LEVODOPA&lt;/subtitle&gt;

1974 • 60 citations

PLASMA UPTAKE OF DOPAMINE AND 5-HYDROXYTRYPTAMINE AND PLASMA-CATECHOLAMINE LEVELS IN PATIENTS WITH HUNTINGTON'S CHOREA

1974 • 58 citations

Enhancement of audiogenic seizure by 6-hydroxydopamine

1972 • 58 citations

EFFECT OF SELECTIVE DESTRUCTION OF CENTRAL AND PERIPHERAL CATECHOLAMINE‐CONTAINING NEURONES WITH 6‐HYDROXYDOPAMINE ON CATECHOLAMINE EXCRETION IN THE RAT

1974 • 56 citations

Pathogenesis of phenylketonuria: Inhibition of dopa and catecholamine synthesis in patients with phenylketonuria

1972 • 55 citations

Amine metabolites in the cerebrospinal fluid in Huntington's chorea

1972 • 54 citations

Some speculations concerning a possible biochemical basis of minimal brain dysfunction

1974 • 51 citations

Tardive dyskinesia treated with pimozide

1975 • 51 citations

Serum amino acid concentrations in alcoholic hepatitis.

1967 • 51 citations

Epinephrine Metabolism in Phenylketonuria.

1961 • 49 citations

ACID MONOAMINE METABOLITES IN CEREBROSPINAL FLUID FROM PATIENTS WITH PRESENILE DEMENTIA (ALZHEIMER'S DISEASE)

1973 • 48 citations

Striatonigral degeneration

1973 • 46 citations

Mechanisms of norepinephrine accumulation within sites of spinal cord injury

1974 • 44 citations

Observations on the Efficacy of L-Dopa in Progressive Supranuclear Palsy

1971 • 44 citations

SERUM DOPAMINE-β-HYDROXYLASE ACTIVITY IN PATIENTS WITH HUNTINGTON'S CHOREA AND PARKINSON'S DISEASE

1972 • 44 citations

Catecholamine levels in the injured spinal cord of monkeys

1975 • 44 citations

Effects of L-dopa administration of the concentrations of dopa, dopamine and norepinephrine in various rat tissues.

1973 • 42 citations

[Homovanillic acid in the cerebrospinal fluid: studies in Parkinson's syndrome and other diseases of the CNS].

1966 • 41 citations

Torsion dystonia and spasmodic torticollis results of treatment with L-dopa

1970 • 39 citations

Gilles de la Tourette's disease and minimal brain dysfunction: Amphetamine isomers reveal catecholamine correlates in an affected patient

1973 • 38 citations

Cereal ingestion and catecholamine excretion

1974 • 38 citations

TREATMENT OF WILSON'S DISEASE WITH L-DOPA AFTER FAILURE WITH PENICILLAMINE

1970 • 37 citations

EXCRETION OF CATECHOLAMINE METABOLITES BY CHILDREN WITH FAMILIAL DYSAUTONOMIA

1970 • 37 citations

Depressed Monoamine Catabolite Levels in Cerebrospinal Fluid of Patients with Parkinsonism Dementia of Guam

1970 • 36 citations

Decreased noradrenaline (norepinephrine) synthesis in familial dysautonomia

1971 • 34 citations

Cerebral Metabolic Changes During Treatment of Subacute Cerebral Infarction by Alpha and Beta Adrenergic Blockade With Phenoxybenzamine and Propranolol

1974 • 33 citations

STUDIES OF THE MONOAMINE METABOLISM IN THE CENTRAL NERVOUS SYSTEM IN JAKOB-CREUTZFELDT DISEASE

1971 • 33 citations

The effects of intracerebroventricularly administered noradnamine and other sympathomimetic amines upon leptazol convulsions in mice

1968 • 31 citations

MEDICAL TREATMENT OF SPASMODIC TORTICOLLIS

1972 • 31 citations

Estimation of 5-hydroxytryptamine (5-HT) level in cerebrospinal fluid of patients with intracranial or spinal lesions.

1967 • 30 citations

Zur Beeinflussung der Akinese und anderer extrapyramidal-motorischer Störungen mit L-Dopa (L-Dihydroxyphenylalanin)

1964 • 29 citations

The effects of 6-hydroxydopamine pretreatment on the accumulation of dopa and dopamine in brain and peripheral organs following l-dopa administration

1972 • 29 citations

Biochemical and pharmacologic studies of dystonia

1970 • 28 citations

Das Verhalten des Dopamin-Metaboliten Homovanillinsäure im Gehirn von normalen und Parkinson-kranken Menschen

1964 • 26 citations

LEVODOPA IN DYSTONIA MUSCULORUM DEFORMANS

1973 • 26 citations

The effect of hyperbaric oxygenation of cerebral amines

1966 • 25 citations

Noradrenergic mediation of traumatic spinal cord autodestruction

1974 • 25 citations

FAMILIAL DYSAUTONOMIA: CLINICAL AND PATHOPHYSIOLOGICAL ASPECTS

1974 • 25 citations

Rationale for the use of L‐dopa in the torsion dystonias

1970 • 24 citations

The treatment of dystonia with L‐dopa and haloperidol

1970 • 24 citations

A familial study in serum dopamine‐β‐hydroxylase levels in torsion dystonia

1974 • 23 citations

Brain norepinephrine and serotonin in central oxigen toxicity

1971 • 22 citations

L-Dopa in Parkinsonism associated with cerebellar dysfunction (probable olivopontocerebellar degeneration)

1971 • 22 citations

Treatment and prevention of acute hepatic encephalopathy by intravenous levodopa.

1974 • 22 citations

Normal excretion of homovanillic acid in the urine of patients with Huntington's chorea.

1961 • 21 citations

Cortical Cataracts in Infants Nourished Parenterally

1975 • 21 citations

CSF homovanillic acid: Effects of probenec id and α-methyltyrosine

1970 • 20 citations

Spasmodic Torticollis Treated Effectively by Medical Means

1971 • 18 citations

GILLES DE LA TOURETTE'S DISEASE IN CHILDREN: TREATMENT WITH PHENOTHIAZINE DRUGS

1964 • 18 citations

LEVODOPA-INDUCED DYSTONIA

1972 • 15 citations

Wilson's Disease: Modification by L-Dopa

1973 • 14 citations

Alterations in spinal cord norepinephrine levels following experimentally produced trauma in normal and adrenalectomized cats

1974 • 14 citations

[On the diagnostic value of homovanillic acid in the cerebrospinal fluid].

1967 • 13 citations

Treatment of Spasmodic Torticollis

1972 • 13 citations

Spasmodic torticollis and L‐dopa

1972 • 13 citations

Brain Synapses

1972 • 12 citations

LEVODOPA IN DYSTONIA MUSCULORUM DEFORMANS

1973 • 10 citations

Dopamine histofluorescence: restoration in mammalian brain tissues prepared several hours post mortem

1973 • 10 citations

LEVODOPA IN DYSTONIA

1973 • 10 citations

[Favorable results with an association of L-dopa and amantadine added to penicillamine in the treatment of Wilson's disease].

1973 • 9 citations

HOMOVANILLIC ACID AND 5‐HYDROXYINDOLEACETIC ACID IN CEREBROSPINAL FLUID OF A CHILD WITH FAMILIAL DYSAUTONOMIA

1973 • 8 citations

HALOPERIDOL IN SPASMODIC TORTICOLLIS

1972 • 7 citations

Hepatic Encephalopathy Treated With L-Dopa, Recovery Followed for 18 Months

1973 • 5 citations

Studies of catecholamine metabolism in two hereditary forms of dystonia.

1973 • 1 citations