Loss of immune competence with age may be due to auto-anti-idiotypic antibody regulation

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1968 • 2,480 citations

Science and Information Theory

1956 • 1,940 citations

Handbook of experimental immunology

1974 • 473 citations

Idiotype suppression. II. Amplification of a suppressor T cell with anti‐idiotypic activity

1975 • 246 citations

Immunological studies of aging. II. Loss of IgG and high avidity plaque-forming cells and increased suppressor cell activity in aging mice.

1976 • 239 citations

Immune function in aged mice

1977 • 143 citations

Studies of Structure and Immunosuppression of a Cross‐Reactive Idiotype in Strain A Mice

1977 • 134 citations

Humoral immunity in aged mice. II. Increased suppressor T cell activity in immunologically deficient old mice.

1976 • 124 citations

Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. I. Occurrence in AKR/J and BALB/c mice of hapten-augmentable, anti-TNP plaque-forming cells and their accelerated appearance in recipients of immune spleen cells

1979 • 113 citations

Production of auto-anti-idiotypic antibody during the normal immune response to TNP-ficoll. II. Hapten-reversible inhibition of anti-TNP plaque-forming cells by immune serum as an assay for auto-anti-idiotypic antibody

1979 • 89 citations

Age-Related Decline in Response to Phytohemagglutinin and Pokeweed Mitogen by Spleen Cells from Hamsters and a Long-Lived Mouse Strain

1973 • 87 citations

Age-Related Changes in T Cell Function

1977 • 85 citations

Immune function in aged mice IV. Loss of T cell and B cell function in thymus‐dependent antibody responses

1978 • 80 citations

Humoral Immunity in Aged Mice

1976 • 69 citations

Incidence and specificities of IgA and IgM anti-AgG autoantibodies in various mouse strains and colonies.

1980 • 63 citations

Loss of immune competence with age may be due to a qualitative abnormality in lymphocyte membranes

1979 • 57 citations

Immune function in aged mice. V. Role of suppressor cells.

1980 • 47 citations

Suppression by autogenous complementary idiotypes: the priority of the first response.

1976 • 42 citations

Mechanisms of idiotype suppression. I. In vitro generation of idiotype-specific suppressor T cells by anti-idiotype antibodies and specific antigen.

1979 • 36 citations

Aging Increases Expression of LPS-Induced Autoantibody-Secreting B Cells

1979 • 30 citations

Aging Increases Expression of LPS-Induced Autoantibody-Secreting B Cells

1979 • 24 citations