NMDA and AMPA receptors: old channels, new tricks

Synaptic Plasticity and Memory: An Evaluation of the Hypothesis

2000 • 2,700 citations

Homeostatic plasticity in the developing nervous system

2004 • 2,371 citations

Activity-dependent scaling of quantal amplitude in neocortical neurons

1998 • 2,213 citations

Genetic enhancement of learning and memory in mice

1999 • 1,831 citations

NMDA receptor subunits: diversity, development and disease

2001 • 1,677 citations

Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways

2002 • 1,612 citations

Role of NMDA Receptor Subtypes in Governing the Direction of Hippocampal Synaptic Plasticity

2004 • 1,084 citations

Calcium regulation of neuronal gene expression

2001 • 1,003 citations

Mitogen-activated protein kinases in synaptic plasticity and memory

2004 • 975 citations

Structural plasticity and memory

2004 • 971 citations

Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors

2006 • 778 citations

Direct interactions between PSD-95 and stargazin control synaptic AMPA receptor number

2002 • 729 citations

EphB Receptors Interact with NMDA Receptors and Regulate Excitatory Synapse Formation

2000 • 702 citations

NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII

2005 • 685 citations

Regulatory mechanisms of AMPA receptors in synaptic plasticity

2007 • 677 citations

NF-κB functions in synaptic signaling and behavior

2003 • 672 citations

Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons

1998 • 640 citations

Regulation of transcription factors by neuronal activity

2002 • 584 citations

Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation

2006 • 523 citations

Miniature synaptic events maintain dendritic spines via AMPA receptor activation

1999 • 522 citations

Functional studies and distribution define a family of transmembrane AMPA receptor regulatory proteins

2003 • 518 citations

Differential Roles of NR2A- and NR2B-Containing NMDA Receptors in Ras-ERK Signaling and AMPA Receptor Trafficking

2005 • 480 citations

Activity-Dependent Dendritic Arborization Mediated by CaM-Kinase I Activation and Enhanced CREB-Dependent Transcription of Wnt-2

2006 • 455 citations

Glutamate receptors regulate actin-based plasticity in dendritic spines

2000 • 446 citations

Regulation of Ca2+-permeable AMPA receptors: synaptic plasticity and beyond

2006 • 434 citations

The NMDA Receptor Is Coupled to the ERK Pathway by a Direct Interaction between NR2B and RasGRF1

2003 • 427 citations

Increased Expression of the Immediate-Early Gene Arc/Arg3.1 Reduces AMPA Receptor-Mediated Synaptic Transmission

2006 • 407 citations

Heterogeneity in the Molecular Composition of Excitatory Postsynaptic Sites during Development of Hippocampal Neurons in Culture

1998 • 396 citations

Insights into immediate‐early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches

2002 • 384 citations

Synapse-Specific and Developmentally Regulated Targeting of AMPA Receptors by a Family of MAGUK Scaffolding Proteins

2006 • 378 citations

Activity Coregulates Quantal AMPA and NMDA Currents at Neocortical Synapses

2000 • 344 citations

NMDA receptor surface mobility depends on NR2A-2B subunits

2006 • 343 citations

NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling

2002 • 312 citations

Opposing role of synaptic and extrasynaptic NMDA receptors in regulation of the extracellular signal‐regulated kinases (ERK) activity in cultured rat hippocampal neurons

2006 • 304 citations

Induction of dendritic spines by an extracellular domain of AMPA receptor subunit GluR2

2003 • 302 citations

Neuronal activity‐dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5

2003 • 296 citations

Subunit Rules Governing the Sorting of Internalized AMPA Receptors in Hippocampal Neurons

2004 • 277 citations

Regulation of Dendritic Protein Synthesis by Miniature Synaptic Events

2004 • 273 citations

The AMPA receptor interacts with and signals through the protein tyrosine kinase Lyn

1999 • 271 citations

TARP γ-8 controls hippocampal AMPA receptor number, distribution and synaptic plasticity

2005 • 268 citations

Nuclear Ca²+ and the cAMP Response Element-Binding Protein Family Mediate a Late Phase of Activity-Dependent Neuroprotection

2005 • 258 citations

Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus

2005 • 249 citations

Arc/Arg3.1: Linking Gene Expression to Synaptic Plasticity and Memory

2006 • 248 citations

Regulation of mitogen‐activated protein kinases by glutamate receptors

2006 • 230 citations

Generation of Silent Synapses by Acute In Vivo Expression of CaMKIV and CREB

2005 • 218 citations

Opposing roles of synaptic and extrasynaptic NMDA receptors in neuronal calcium signalling and BDNF gene regulation

2003 • 213 citations

Ca2+ channel-regulated neuronal gene expression

1998 • 204 citations

Ca²⁺-Permeable AMPA Receptors Induce Phosphorylation of cAMP Response Element-Binding Protein through a Phosphatidylinositol 3-Kinase-Dependent Stimulation of the Mitogen-Activated Protein Kinase Signaling Cascade in Neurons

1999 • 197 citations

The AMPA Receptor Subunits GluR-A and GluR-B Reciprocally Modulate Spinal Synaptic Plasticity and Inflammatory Pain

2004 • 195 citations

AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc

2006 • 187 citations

CREB, Synapses and Memory Disorders: Past Progress and Future Challenges

2005 • 184 citations

Distinct Roles for Ras-Guanine Nucleotide-Releasing Factor 1 (Ras-GRF1) and Ras-GRF2 in the Induction of Long-Term Potentiation and Long-Term Depression

2006 • 184 citations

Excitation-Transcription Coupling: Signaling by Ion Channels to the Nucleus

2003 • 164 citations

A proportional but slower NMDA potentiation follows AMPA potentiation in LTP

2004 • 162 citations

Glutamate induces the rapid formation of spine head protrusions in hippocampal slice cultures

2005 • 159 citations

AMPA receptor-mediated regulation of a Gi-protein in cortical neurons

1997 • 155 citations

A Novel Ca²⁺-Independent Signaling Pathway to Extracellular Signal-Regulated Protein Kinase by Coactivation of NMDA Receptors and Metabotropic Glutamate Receptor 5 in Neurons

2004 • 139 citations

Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB

2004 • 132 citations

Glutamate Signaling to Ras-MAPK in Striatal Neurons: Mechanisms for Inducible Gene Expression and Plasticity

2004 • 109 citations

Late-phase long-term potentiation: getting to the nucleus

2005 • 95 citations

AMPA protects cultured neurons against glutamate excitotoxicity through a phosphatidylinositol 3‐kinase‐dependent activation in extracellular signal‐regulated kinase to upregulate BDNF gene expression

2004 • 91 citations

α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, but Not N-Methyl-D-aspartate, Activates Mitogen-activated Protein Kinase through G-protein βγ Subunits in Rat Cortical Neurons

1995 • 79 citations

Splice Variants of the NR1 Subunit Differentially Induce NMDA Receptor-Dependent Gene Expression

2006 • 67 citations

A Novel Pathway for Presynaptic Mitogen-Activated Kinase Activation via AMPA Receptors

2005 • 66 citations

AMPA Receptor Activates a G-Protein that Suppresses a cGMP-Gated Current

1999 • 66 citations

Age-dependent Participation of Ras-GRF Proteins in Coupling Calcium-permeable AMPA Glutamate Receptors to Ras/Erk Signaling in Cortical Neurons

2006 • 55 citations

Excitotoxicity mediated by Ca2+-permeable GluR4-containing AMPA receptors involves the AP-1 transcription factor

2005 • 19 citations

Characterization of NMDA- and AMPA-induced enhancement of AP-1 DNA binding activity in rat cerebellar granule cells

1997 • 18 citations

Spine-Tingling Excitement from Glutamate Receptors

2003 • 4 citations