Inhibitors of GABA metabolism

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

1978 • 998 citations

Huntington's Chorea

1973 • 845 citations

γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE¹

1977 • 472 citations

Biochemical-physiology correlations in studies of the γ-aminobutyric acid system

1968 • 408 citations

4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain

1977 • 375 citations

Suicide enzyme inactivators

1976 • 366 citations

Some properties of L-glutamic decarboxylase in mouse brain

1963 • 335 citations

Effect of sodium n-dipropylacetate on audiogenic seizures and brain γ-aminobutyric acid level

1973 • 285 citations

Chemistry and Enzymology of k _cat Inhibitors

1974 • 283 citations

Glutamate and γ-Aminobutyric Acid in Brain

1970 • 269 citations

γ-aminobutyric acid and nervous system function—A perspective

1974 • 269 citations

Elevation of γ-Aminobutyric Acid in Brain: Selective Inhibition of γ-Aminobutyric-α-ketoglutaric Acid Transaminase

1961 • 224 citations

THE EFFECT OF 4‐AMINO HEX‐5‐YNOIC ACID (γ‐ACETYLENIC GABA, γ‐ETHYNYL GABA) A CATALYTIC INHIBITOR OF GABA TRANSAMINASE, ON BRAIN GABA METABOLISM IN VIVO

1977 • 216 citations

Soluble γ-Aminobutyric-Glutamic Transaminase from Pseudomonas fluorescens

1959 • 212 citations

Audiogenic seizure protection by elevated brain GABA concentration in mice: Effects of γ-acetylenic GABA and γ-vinyl GABA, two irreversible GABA-T inhibitors

1977 • 203 citations

PROPERTIES OF BRAIN <scp>l</scp>‐GLUTAMATE DECARBOXYLASE: INHIBITION STUDIES¹

1974 • 186 citations

Choline acetylase and glutamic acid decarboxylase in Huntington's chorea

1973 • 180 citations

Active-site-directed irreversible inhibition of rat brain 4-aminobutyrate aminotransferase by ethanolamine O-sulphate in vitro and in vivo

1972 • 178 citations

REDUCED GLUTAMIC-ACID- DECARBOXYLASE ACTIVITY OF POST-MORTEM BRAIN IN HUNTINGTON'S CHOREA

1973 • 168 citations

Elevation of γ-aminobutyric acid in brain with amino-oxyacetic acid and susceptibility to convulsive seizures in mice: A quantitative re-evaluation

1966 • 166 citations

Seizures induced by allylglycine, 3‐mercaptopropionic acid and 4‐deoxypyridoxine in mice and photosensitive baboons, and different modes of inhibition of cerebral glutamic acid decarboxylase

1973 • 152 citations

Mechanism of the irreversible inhibition of γ-aminobutyric acid-α-ketoglutaric acid transaminase by the neurotoxin gabaculine

1977 • 141 citations

Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog

1975 • 136 citations

THE ROLE OF GABA METABOLISM IN THE CONVULSANT AND ANTICONVULSANT ACTIONS OF AMINOOXYACETIC ACID

1973 • 119 citations

MERCAPTOPROPIONIC ACID: A CONVULSANT THAT INHIBITS GLUTAMATE DECARBOXYLASE¹

1970 • 118 citations

Effect of n‐dipropylacetate on amino acid concentrations in mouse brain: correlations with anti‐convulsant activity

1978 • 108 citations

4-Aminobutyrate in mammalian putrescine catabolism

1975 • 102 citations

Dipropylacetate (Depakine®, Ergenyl®) in the Treatment of Epilepsy

1973 • 101 citations

Irreversible inhibition of aspartate aminotransferase by 2-amino-3-butenoic acid

1974 • 98 citations

Enzyme-activated irreversible inhibitors of L-ornithine:2-oxoacid aminotransferase. Demonstration of mechanistic features of the inhibition of ornithine aminotransferase by 4-aminohex-5-ynoic acid and gabaculine and correlation with in vivo activity.

1978 • 97 citations

The in vivo inhibition of gaba-transaminase by gabaculine

1977 • 88 citations

THE EFFECT ON GABA METABOLISM IN BRAIN OF ISONICOTINIC ACID HYDRAZIDE AND PYRIDOXINE AS A FUNCTION OF TIME AFTER ADMINISTRATION

1972 • 75 citations

Reaction of L-serine O-sulfate with aspartate aminotransferase

1969 • 71 citations

The in vivo effects of hydrazines and vitamin B6 on the metabolism of gamma-aminobutyric acid.

1963 • 69 citations

Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase.

1977 • 68 citations

Evidence for a role of glutamate decarboxylase activity as a regulatory mechanism of cerebral excitability

1975 • 66 citations

D‐ AND L‐STEREOISOMERS OF ALLYLGLYCINE: CONVULSIVE ACTION AND INHIBITION OF BRAIN L‐GLUTAMATE DECARBOXYLASE

1977 • 65 citations

CORRELATIVE CHANGES OF PYRIDOXAL KINASE PYRIDOXAL‐5′‐PHOSPHATE AND GLUTAMATE DECARBOXYLASE IN BRAIN, DURING DRUG‐INDUCED CONVULSIONS

1969 • 59 citations

DEVELOPMENT OF AN EXPRESSION WHICH RELATES THE EXCITABLE STATE OF THE BRAIN TO THE LEVEL OF GAD ACTIVITY AND GABA CONTENT, WITH PARTICULAR REFERENCE TO THE ACTION OF HYDRAZINE AND ITS DERIVATIVES

1974 • 58 citations

Gabaculine: γ-aminobutyrate aminotransferase inhibitor of microbial origin

1976 • 55 citations

Inhibition of Incorporation of Thymidine into Deoxyribonucleic Acid by Amino Acid Antagonists in Vivo

1960 • 51 citations

G.A.B.A. AND HUNTINGTON'S CHOREA

1973 • 51 citations

Effect of elevated brain GABA concentrations on the actions of bicuculline and picrotoxin in mice

1977 • 50 citations

Effects of sodium dipropylacetate on .GAMMA.-aminobutyric acid and biogenic amines in rat brain.

1977 • 46 citations

HYDRAZINOPROPIONIC ACID: A NEW INHIBITOR OF AMINOBUTYRATE TRANSAMINASE AND GLUTAMATE DECARBOXYLASEI

1968 • 46 citations

Active-site labeling of aspartate aminotransferases by the β,γ-unsaturated amino acid vinylglycine

1977 • 44 citations

Mechanism of the stereospecific irreversible inhibition of bacterial glutamic acid decarboxylase by (R)-(-)-4-aminohex-5-ynoic acid, an analog of 4-aminobutyric acid

1978 • 43 citations

On the mechanism of action of antibiotics which act as irreversible enzyme inhibitors

1975 • 42 citations

The effect of γ-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems

1978 • 41 citations

Effect of ethanolamine-O-sulphate on regional gaba metabolism in the mouse brain

1977 • 37 citations

Effect of 2-methyl 2-ethyl caproic acid and 2-2-dimethyl valeric acid on audiogenic seizures and brain gamma aminobutyric acid

1974 • 34 citations

NEUROCHEMICAL STUDIES WITH <scp>l</scp>‐CYCLOSERINE, A CENTRAL DEPRESSANT AGENT

1963 • 31 citations

The inhibition of mouse brain glutamate decarboxylase by some structural analogues of L-glutamic acid

1977 • 31 citations

Effects of Gabaculine on the uptake, binding and metabolism of GABA

1977 • 30 citations

Isolation of 4.5‐Dihydroxyisophthalic Acid, an Inhibitor of Brain Glutamate Decarboxylase, Produced by a Streptomyces Species

1978 • 9 citations

L-α-amino-β-chloropropionic acid hydroxamide: An inhibitor of GABA-α-oxoglutarate aminotransferase

1976 • 5 citations

Differential Effects of <scp>d</scp>- and <scp>l</scp>-Allylglycine (2-Aminopent-4-enoic Acid) on Regional Cerebral γ-Aminobutyrate Concentrations

1978 • 3 citations