Molecular Mechanism of Gonadotropin Releasing Hormone (GnRH) Action. I. The GnRH Receptor*

Hypophysial Responses to Continuous and Intermittent Delivery of Hypothalamic Gonadotropin-Releasing Hormone

1978 • 1,363 citations

Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts

1981 • 593 citations

Receptor-mediated endocytosis

1985 • 577 citations

Gonadotropin-Releasing Hormone Receptors: Characterization, Physiological Regulation, and Relationship to Reproductive Function

1981 • 530 citations

Extrapituitary Actions of Gonadotropin-Releasing Hormone*

1981 • 445 citations

Phorbol esters induce transient internalization without degradation of unoccupied epidermal growth factor receptors.

1985 • 199 citations

Gonadotropin-Releasing Hormone Action in the Pituitary: A Three Step Mechanism*

1981 • 192 citations

Desensitization to Gonadotropin-Releasing Hormone Observed in Superfused Pituitary Cells on Cytodex Beads*

1981 • 176 citations

Conversion of a gonadotropin-releasing hormone antagonist to an agonist

1982 • 174 citations

Receptor-mediated internalization of fluorescent gonadotropin-releasing hormone by pituitary gonadotropes.

1980 • 173 citations

Homologous Regulation of Gonadotropin-Releasing Hormone Receptors in Cultured Pituitary Cells

1982 • 162 citations

The Molecular Mechanism of Action of Gonadotropin Releasing Hormone (GnRH) in the Pituitary

1987 • 153 citations

Conformational energy analysis of the molecule, luteinizing hormone-releasing hormone. 1. Native decapeptide

1976 • 144 citations

Quantitative immunocytochemistry of pituitary receptors for luteinizing hormone-releasing hormone

1975 • 141 citations

Characterization of Gonadotropin-Releasing Hormone Receptors in Cultured Rat Pituitary Cells

1980 • 138 citations

Regulation of the rat pituitary gonadotropin-releasing hormone receptor.

1981 • 127 citations

Complete inhibition of transferrin recycling by monensin in K562 cells.

1984 • 120 citations

The Molecular Basis of Gonadotropin-Releasing Hormone (GnRH) Action in the Pituitary Gonadotrope1

1987 • 113 citations

Topographical localization of the receptors for luteinizing hormone-releasing hormone on the surface of dissociated pituitary cells.

1977 • 113 citations

Receptor-Binding Affinity of Gonadotropin-Releasing Hormone Analogs: Analysis by Radioligand-Receptor Assay

1980 • 111 citations

Gonadotropin-Releasing Hormone

1975 • 105 citations

Interaction of fluorescent gonadotropin-releasing hormone with receptors in cultured pituitary cells.

1981 • 93 citations

Biphasic regulation of the gonadotropin-releasing hormone receptor by receptor microaggregation and intracellular Ca2+ levels.

1984 • 93 citations

POTENCY ENHANCEMENT OF A GnRH AGONIST: GnRH-RECEPTOR MICROAGGREGATION STIMULATES GONADOTROPIN RELEASE

1982 • 83 citations

Fate of a Gonadotropin-Releasing Hormone Agonist Internalized by Rat Pituitary Gonadotrophs*

1983 • 83 citations

Desensitization of cultured pituitary cells to gonadotropin-releasing hormone: Evidence for a post-receptor mechanism

1983 • 82 citations

Binding and Internalization of a Luteinizing Hormone-Releasing Hormone Agonist by Rat Gonadotrophic Cells. A Radioautographic Study

1982 • 81 citations

Luteinizing Hormone Release and Gonadotropin-Releasing Hormone (GnRH) Receptor Internalization: Independent Actions of GnRH*

1981 • 76 citations

Stimulation of pituitary gonadotropin release does not require internalization of gonadotropin-releasing hormone.

1981 • 69 citations

PHOTOAFFINITY LABELING OF LUTEINIZING HORMONE RELEASING HORMONE RECEPTOR OF RAT PITUITARY MEMBRANE PREPARATIONS

1981 • 67 citations

GnRH-MEDIATED DESENSITIZATION OF THE PITUITARY GONADOTROPE IS NOT CALCIUM DEPENDENT

1983 • 62 citations

Uptake, localization, and retention of gonadotropin-releasing hormone and gonadotropin-releasing hormone analogs in rat gonadotrophs

1980 • 59 citations

The calcium requirement in GnRH-stimulated LH release is not mediated through a specific action on receptor binding

1980 • 59 citations

Coincidence of down-regulation and desensitization in pituitary gonadotrophs stimulated by gonadotropin releasing hormone

1983 • 59 citations

Photoaffinity-labeling and fluorescence-distribution studies of gonadotropin-releasing hormone receptors in ovarian granulosa cells.

1982 • 59 citations

Localization of biotinylated gonadotropin releasing hormone on pituitary monolayer cells with avidin-biotin-peroxidase complexes.

1983 • 57 citations

Gonadotropin-releasing hormone stimulation of luteinizing hormone release: A ligand-receptor-effector model.

1982 • 57 citations

Luteinizing hormone release from dissociated pituitary cells by dimerization of occupied LHRH receptors

1982 • 56 citations

Cytochemical characterization of pituitary target cells for biotinylated gonadotropin releasing hormone

1983 • 54 citations

Subcellular Localization of the Receptor for Gonadotropin-Releasing Hormone in Pituitary and Ovarian Tissue*

1983 • 54 citations

Some characteristics of GnRH receptors in rat-pituitary membranes: Differences between an agonist and an antagonist

1981 • 52 citations

Intracellular Pathways of Electron-Opaque Gonadotropin-Releasing Hormone Derivatives Bound by Cultured Gonadotropes^*

1983 • 51 citations

Solubilization and purification of rat pituitary gonadotropin-releasing hormone receptor.

1986 • 50 citations

Receptor-mediated binding and uptake of GnRH agonist and antagonist by pituitary cells

1984 • 49 citations

Homologous Desensitization with Gonadotropin-Releasing Hormone (GnRH) also Diminishes Gonadotrope Responsiveness to Maitotoxin: A Role for the GnRH Receptor-Regulated Calcium Ion Channel in Mediation of Cellular Desensitization*

1987 • 48 citations

Desensitization of luteinizing hormone release in cultured pituitary cells by gonadotropin-releasing hormone

1983 • 47 citations

Microaggregation of the Gonadotropin-Releasing Hormone-Receptor: Relation to Gonadotrope Desensitization*

1984 • 45 citations

Binding of luteinizing hormone-releasing hormone analogues to dispersed rat pituitary cells

1981 • 44 citations

Quantification of pituitary membrane receptor sites to LHRH: Use of a superactive analog as tracer

1979 • 42 citations

Structural features of luliberin (luteinising hormone-releasing factor) inferred from fluorescence measurements

1976 • 40 citations

GnRH-Receptor of rat pituitary is a glycoprotein: Differential effect of neuraminidase and lectins on agonists and antagonists binding

1982 • 39 citations

Radiation Inactivation (Target Size Analysis) of the Gonadotropin-Releasing Hormone Receptor: Evidence for a High Molecular Weight Complex*

1985 • 38 citations

Demonstration of a 60K Molecular Weight Luteinizing Hormone-Releasing Hormone Receptor in Solubilized Adrenal Membranes by a Ligand-Immunoblotting Technique*

1985 • 37 citations

Photoaffinity Labeling of Peptide Hormone Receptors*

1983 • 36 citations

Binding and internalization of native gonadoliberin (GnRH) by anterior pituitary gonadotrophs of the rat

1987 • 33 citations

Internalization and recycling of receptor-bound gonadotropin-releasing hormone agonist in pituitary gonadotropes.

1987 • 33 citations

Receptor-mediated internalization of LHRH antagonists by pituitary cells

1983 • 31 citations

Cytochemical Evidence for Different Routes of Gonadotropin-Releasing Hormone Processing by Large Gonadotropes and Granulosa Cells^*

1986 • 30 citations

Monensin, like methylamine, prevents degradation of 125I-epidermal growth factor, causes intracellular accumulation of receptors and blocks the mitogenic response

1984 • 28 citations

Tunicamycin and Neuraminidase Effects on Luteinizing Hormone (LH)-Releasing Hormone Binding and LH Release from Rat Pituitary Cells in Culture*

1985 • 27 citations

Receptor-mediated uptake of GnRH agonist and antagonists by cultured gonadotropes: Evidence for differential intracellular routing

1986 • 26 citations

Intracellular pathways of receptor-bound GnRH agonist in pituitary gonadotropes

1985 • 26 citations

A NOVEL METHOD FOR LOCALIZATION OF GONADOTROPIN RELEASING HORMONE RECEPTORS

1982 • 23 citations

Gonadotropin releasing hormone activation is mediated by dimerization of occupied receptors

1985 • 23 citations

SOLUBILIZATION OF THE GONADOTROPIN-RELEASING HORMONE RECEPTOR FROM BOVINE PITUITARY PLASMA MEMBRANES

1983 • 22 citations

Solubilization of pituitary GnRH binding sites by means of a zwitterionic detergent

1983 • 22 citations

Mapping of gonadotropin-releasing hormone receptor binding site

1985 • 21 citations

Receptors for luteinizing hormone-releasing hormone.

1978 • 21 citations

Photoaffinity labeling of pituitary gonadotropin releasing hormone receptors during the rat estrous cycle

1982 • 20 citations

Covalent linking of photoreactive gonadotropin-releasing hormone to gonadotropes produces a prolonged signal.

1983 • 19 citations

Solubilized active pituitary and ovarian gonadotropin-releasing hormone receptors retain binding properties for adenosine 3′, 5′-cyclic monophosphate derivatives

1984 • 18 citations

Structure-activity relationships of luliberin substituted at position 8

1976 • 17 citations

Gonadotropin releasing-hormone receptors: Photoaffinity labeling with an antagonist

1983 • 17 citations

Receptor-mediated endocytosis of GnRH analogs: Differential processing of gold-labeled agonist and antagonist derivatives

1986 • 16 citations

Photoaffinity labeling of gonadotropin releasing hormone receptors in control and desensitized pituitary cells

1984 • 15 citations

Role of lipids in gonadotropin releasing hormone agonist and antagonist binding to rat pituitary

1982 • 14 citations

[4] Photoaffinity labeling in neuroendocrine tissues

1983 • 14 citations

Binding properties of solubilized gonadotropin-releasing hormone receptor: role of carboxylic groups

1987 • 13 citations

Production and characterization of antibodies to gonadotropin-releasing hormone receptor.

1987 • 13 citations

Solubilization and partial purification of the high-affinity gonadoliberin receptor from the bovine pituitary gland

1983 • 11 citations

The Metabolism of Insulin Receptors: Internalization, Degradation, and Recycling

1985 • 10 citations

LHRH: Clinical applications growing

1985 • 10 citations

Activation of Luteinizing Hormone Release from Pituitary Cells by Polycations^*

1984 • 10 citations

[3] Ligand dimerization: A technique for assessing receptor-receptor interactions

1983 • 10 citations

[5] Preparation and use of biotinylated neuroendocrine peptides

1986 • 9 citations

Characterization of GnRH receptors in bovine pituitary membranes

1984 • 8 citations

Testicular GnRH receptors: Photoaffinity labeling and fluorescence distribution studies

1984 • 7 citations

Mapping of gonadotropin-releasing hormone-receptor binding site using selective chemical modifications

1989 • 2 citations