Expression of the glial glutamate transporter EAAT2 in the human CNS: an immunohistochemical study

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Studies on transformation of Escherichia coli with plasmids

1983 • 11,179 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

1996 • 2,470 citations

Glutamate: A Neurotransmitter in Mammalian Brain

1984 • 1,981 citations

Localization of neuronal and glial glutamate transporters

1994 • 1,668 citations

Selective loss of glial glutamate transporter GLT‐1 in amyotrophic lateral sclerosis

1995 • 1,430 citations

Primary structure and functional characterization of a high-affinity glutamate transporter

1992 • 1,319 citations

Cloning and expression of a rat brain L-glutamate transporter

1992 • 1,230 citations

Structure, expression, and functional analysis of a Na(+)-dependent glutamate/aspartate transporter from rat brain.

1992 • 1,185 citations

Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

1992 • 1,170 citations

An excitatory amino-acid transporter with properties of a ligand-gated chloride channel

1995 • 1,124 citations

The release and uptake of excitatory amino acids

1990 • 1,090 citations

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

1994 • 988 citations

A reliable method for the recovery of DNA fragments from agarose and acrylamide gels

1981 • 916 citations

Differential expression of two glial glutamate transporters in the rat brain: quantitative and immunocytochemical observations

1995 • 884 citations

A radical hypothesis for neurodegeneration

1993 • 727 citations

Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

1990 • 630 citations

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 • 623 citations

Brain Glutamate Transporter Proteins Form Homomultimers

1996 • 471 citations

Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro.

1996 • 420 citations

Chapter 7 Immunofluorescence and Immunocytochemical Procedures with Affinity Purified Antibodies: Tubulin-Containing Structures

1982 • 382 citations

Motor Neurons Are Selectively Vulnerable to AMPA/Kainate Receptor-Mediated InjuryIn Vitro

1996 • 368 citations

Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons

1990 • 355 citations

Block of glutamate transporters potentiates postsynaptic excitation

1994 • 345 citations

Tissue pH as an indicator of mRNA preservation in human post-mortem brain

1995 • 318 citations

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

1997 • 294 citations

CSF and Plasma Amino Acid Levels in Motor Neuron Disease: Elevation of CSF Glutamate in a Subset of Patients

1995 • 264 citations

The high affinity uptake system for excitatory amino acids in the brain

1994 • 257 citations

Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex

1996 • 237 citations

The neuroexcitotoxic amino acids glutamate and aspartate are altered in the spinal cord and brain in amyotrophic lateral sclerosis

1988 • 210 citations

Glutamine from Glial Cells Is Essential for the Maintenance of the Nerve Terminal Pool of Glutamate: Immunogold Evidence from Hippocampal Slice Cultures

1995 • 189 citations

Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis.

1995 • 174 citations

Pharmacologically distinct sodium-dependentl-[3H]glutamate transport processes in rat brain

1991 • 152 citations

Expression of the glutamate transporter GLT1 in neural cells of the rat central nervous system: Non-radioactive in situ hybridization and comparative immunocytochemistry

1996 • 150 citations

Excitatory amino acid receptors in the human cerebral cortex: A quantitative autoradiographic study comparing the distributions of [3H]TCP, [3H]glycine,l-[3H]glutamate, [3H]AMPA and [3H]kainic acid binding sites

1989 • 135 citations

The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport.

1994 • 132 citations

Regional Deafferentiation Down‐Regulates Subtypes of Glutamate Transporter Proteins

1995 • 128 citations

Reductions in acidic amino acids andN-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS

1991 • 98 citations

Antigen Unmasking in Formalin-Fixed Routinely Processed Paraffin Wax-Embedded Sections by Pressure Cooking

1995 • 75 citations

The quantitative autoradiographic distribution of [3H]MK-801 binding sites in the normal human spinal cord

1991 • 74 citations

Molecular cloning of human brain glutamate/aspartate transporter II

1994 • 74 citations

Regional Heterogeneity of L‐Glutamate and L‐Aspartate High‐Affinity Uptake Systems in the Rat CNS

1991 • 69 citations

Cloning and characterization of a glutamate transporter cDNA from human cerebellum

1993 • 64 citations

Heterogeneity of high affinity uptake of L-glutamate and L-aspartate in the mammalian central nervous system

1992 • 64 citations

[3H]d-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study

1994 • 62 citations

Autoradiographic characterization of putative excitatory amino acid transport sites

1990 • 62 citations

Excitotoxicity in the embryonic chick spinal cord

1991 • 57 citations

AN IMMUNOCYTOCHEMICAL STUDY OF THE DISTRIBUTION OF AMPA SELECTIVE GLUTAMATE RECEPTOR SUBUNITS IN THE NORMAL HUMAN MOTOR SYSTEM

1996 • 43 citations

Excitatory amino acids, free radicals and the pathogenesis of motor neuron disease

1994 • 38 citations

N-methyl-d-aspartate (NMDA) receptors in the spinal cord and motor cortex in motor neuron disease: a quantitative autoradiographic study using [3H]MK-801

1994 • 33 citations

The glial glutamate transporter complementary DNA in patients with amyotrophic lateral sclerosis

1996 • 32 citations

Synaptosomal Glutamate Uptake Declines Progressively in the Spinal Cord of a Mutant Mouse with Motor Neuron Disease

1993 • 29 citations

Autoradiographic distribution of binding sites for the non-NMDA receptor antagonist [3H]CNQX in human motor cortex, brainstem and spinal cord

1993 • 27 citations

A quantitative autoradiographic study of [3H]kainate binding sites in the normal human spinal cord, brainstem and motor cortex

1994 • 19 citations

Brainstem Motoneuron Cell Groups that die in Amyotrophic Lateral Sclerosis are Rich in the GLT-1 Glutamate Transporter

1996 • 1 citations