Clinical pharmacology of UCN-01: Initial observations and comparison to preclinical models

Comprehensive toxicology

1997 • 564 citations

Drug binding to human alpha-1-acid glycoprotein in health and disease.

1988 • 563 citations

UCN-01: a Potent Abrogator of G2 Checkpoint Function in Cancer Cells With Disrupted p53

1996 • 451 citations

Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.

1996 • 221 citations

Human Tumor Xenograft Models in NCI Drug Development

1997 • 219 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

Differential inhibition of protein kinase C isozymes by UCN-01, a staurosporine analogue.

1994 • 161 citations

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

1997 • 155 citations

Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2.

1995 • 137 citations

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.

1993 • 133 citations

7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells.

1997 • 74 citations

Potent selective inhibition of 7-O-methyl UCN-01 against protein kinase C.

1990 • 45 citations

Disposition in mice of 7-hydroxystaurosporine, a protein kinase inhibitor with antitumor activity

1994 • 13 citations