Decreased IFN- γ and increased IL-4 production by human CD8+ T cells in response toMycobacterium tuberculosis in tuberculosis patients

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

1991 • 1,027 citations

Major histocompatibility complex class I-restricted T cells are required for resistance to Mycobacterium tuberculosis infection.

1992 • 771 citations

Global Trends in Resistance to Antituberculosis Drugs

2001 • 673 citations

The Relative Importance of T Cell Subsets in Immunity and Immunopathology of Airborne Mycobacterium tuberculosis Infection in Mice

2001 • 527 citations

Human cytolytic and interferon γ-secreting CD8⁺T lymphocytes specific forMycobacterium tuberculosis

1998 • 364 citations

Impairment of Tetanus Toxoid-Specific Thl-like Immune Responses in Humans Infected with Schistosoma mansoni

1996 • 328 citations

Th1/Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens.

1994 • 309 citations

T-cell cytokine responses in human infection with Mycobacterium tuberculosis

1995 • 291 citations

Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice

2000 • 265 citations

Human Infection withAscaris lumbricoidesIs Associated with a Polarized Cytokine Response

2000 • 257 citations

Infection with Schistosoma mansoni alters Th1/Th2 cytokine responses to a non-parasite antigen.

1992 • 256 citations

Protection againstMycobacterium tuberculosisInfection by CD8⁺T Cells Requires the Production of Gamma Interferon

1998 • 229 citations

Immune response to Mycobacterium bovis bacille Calmette Guérin infection in major histocompatibility complex class I‐ and II‐deficient knock‐out mice: contribution of CD4 and CD8 T cells to acquired resistance

1995 • 220 citations

Type 2 Cytokine Gene Activation and Its Relationship to Extent of Disease in Patients with Tuberculosis

2000 • 220 citations

Increased Production of Interleukin 4 by CD4⁺and CD8⁺T Cells from Patients with Tuberculosis Is Related to the Presence of Pulmonary Cavities

2000 • 210 citations

Early Emergence of CD8⁺T Cells Primed for Production of Type 1 Cytokines in the Lungs ofMycobacterium tuberculosis-Infected Mice

1999 • 181 citations

Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls

1994 • 180 citations

Characterization of Human CD8+ T Cells Reactive with Mycobacterium tuberculosis–infected Antigen-presenting Cells

1998 • 163 citations

Cytokine Profiles for Peripheral Blood Lymphocytes from Patients with Active Pulmonary Tuberculosis and Healthy Household Contacts in Response to the 30-Kilodalton Antigen ofMycobacterium tuberculosis

1998 • 148 citations

Modulation of murine cytokine responses to mycobacterial antigens by helminth-induced T helper 2 cell responses.

1993 • 147 citations

Impact of the HIV epidemic on the spread of other diseases: the case of tuberculosis.

2000 • 143 citations

Mycobacterial diseases

1990 • 141 citations

Increase in Gamma Interferon-Secreting CD8⁺, as Well as CD4⁺, T Cells in Lungs following Aerosol Infection withMycobacterium tuberculosis

1999 • 138 citations

Human alveolar T lymphocyte responses to Mycobacterium tuberculosis antigens: role for CD4+ and CD8+ cytotoxic T cells and relative resistance of alveolar macrophages to lysis.

1997 • 133 citations

Onchocerciasis modulates the immune response to mycobacterial antigens

1999 • 128 citations

Evidence of a T helper type 2 activation in human schistosomiasis

1996 • 123 citations

Stimulation of human peripheral blood mononuclear cells with live Mycobacterium bovis BCG activates cytolytic CD8⁺ T cells in vitro

1996 • 120 citations

Human CD8+ CTL Specific for the Mycobacterial Major Secreted Antigen 85A

2000 • 114 citations

CD8- and CD95/95L-Dependent Mechanisms of Resistance in Mice with Chronic Pulmonary Tuberculosis

2001 • 104 citations

Activation of human CD8+ alpha beta TCR+ cells by Mycobacterium tuberculosis via an alternate class I MHC antigen-processing pathway.

1999 • 102 citations

Characterization of HumanMycobacterium bovisBacille Calmette-Guérin-Reactive CD8⁺T Cells

1999 • 96 citations

In Vitro Synthesis of Interferon-γ, Interleukin-4, Transforming Growth Factor-β and Interleukin-1β by Peripheral Blood Mononuclear Cells from Tuberculosis Patients: Relationship with the Severity of Pulmonary Involvement

1999 • 95 citations

Up-Regulation of VCAM-1 and Differential Expansion of β Integrin-Expressing T Lymphocytes Are Associated with Immunity to PulmonaryMycobacterium tuberculosisInfection

2000 • 89 citations

Activation of Human CD8+ αβ TCR+ Cells byMycobacterium tuberculosisVia an Alternate Class I MHC Antigen-Processing Pathway

1999 • 83 citations

Human CD8⁺T Cells Specific forMycobacterium tuberculosisSecreted Antigens in Tuberculosis Patients and Healthy BCG-Vaccinated Controls in The Gambia

2000 • 75 citations

Dichotomy of Cytokine Profiles in Patients and High-Risk Healthy Subjects Exposed to Tuberculosis

1999 • 62 citations

Dynamics and control of the global tuberculosis epidemic

2000 • 62 citations

Th2 biased immune response in cases with activeMycobacterium tuberculosisinfection and tuberculin anergy

1998 • 50 citations

Th2 biased immune response in cases with active Mycobacterium tuberculosis infection and tuberculin anergy

1998 • 28 citations