Expression of Human Anti-Tetanus Toxoid Antibody in Transfected Murine Myeloma Cells

A simple and very efficient method for generating cDNA libraries

1983 • 4,606 citations

[1] Preparation of monoclonal antibodies: Strategies and procedures

1981 • 1,787 citations

A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene

1983 • 1,418 citations

The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function

1988 • 1,394 citations

Replacing the complementarity-determining regions in a human antibody with those from a mouse

1986 • 1,356 citations

Transfer of a functional human immune system to mice with severe combined immunodeficiency

1988 • 1,248 citations

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase.

1981 • 1,048 citations

Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains.

1984 • 1,002 citations

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

1983 • 436 citations

Gene amplification in cultured cells.

1988 • 289 citations

Human monoclonal antibody production

1987 • 224 citations

Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells.

1983 • 121 citations

Tumor-specific genetically engineered murine/human chimeric monoclonal antibody.

1987 • 49 citations

Cloning and sequence determination of a human rheumatoid factor light-chain gene.

1986 • 47 citations

Prospects for the therapeutic use of human monoclonal antibodies.

1986 • 46 citations

The effect of dihydrofolate reductase-mediated gene amplification on the expression of transfected immunoglobulin genes.

1987 • 40 citations

USE OF CELLULAR MICROENCAPSULATION IN LARGE-SCALE PRODUCTION OF MONOCLONAL ANTIBODIES

1985 • 27 citations

Human monoclonal antibodies — their potential, problems and prospects

1987 • 21 citations

Preparation of medium for large-scale hybridoma culture

1983 • 5 citations

Studies on the production of human monoclonal antibodies

1988 • 1 citations