Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

A Mathematical Contribution to Structure-Activity Studies

1964 • 913 citations

Advances in protein kinase B signalling: AKTion on multiple fronts

2004 • 828 citations

The maximal affinity of ligands

1999 • 817 citations

Fragment-based lead discovery

2004 • 773 citations

Fragment-Based Drug Discovery

2004 • 605 citations

Crystal structure of an activated Akt/Protein Kinase B ternary complex with GSK3-peptide and AMP-PNP

2002 • 492 citations

Akt/Protein Kinase B Signaling Inhibitor-2, a Selective Small Molecule Inhibitor of Akt Signaling with Antitumor Activity in Cancer Cells Overexpressing Akt

2004 • 424 citations

Fragment-Based Lead Discovery Using X-ray Crystallography

2004 • 408 citations

Inhibition of protein kinase B/Akt

2002 • 241 citations

Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo

2005 • 219 citations

The consequences of translational and rotational entropy lost by small molecules on binding to proteins.

2002 • 194 citations

The Akt/PKB Family of Protein Kinases: A Review of Small Molecule Inhibitors and Progress Towards Target Validation

2005 • 148 citations

Probing Hot Spots at Protein−Ligand Binding Sites: A Fragment-Based Approach Using Biophysical Methods

2006 • 131 citations

Targeting Serine / Threonine Protein Kinase B / Akt and Cell-cycle Checkpoint Kinases for Treating Cancer

2002 • 105 citations

The Metabolic Fate of Thiabendazole in Sheep¹

1964 • 97 citations

Automated Protein–Ligand Crystallography for Structure‐Based Drug Design

2006 • 88 citations

A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera

2007 • 84 citations

Unraveling principles of lead discovery: from unfrustrated energy landscapes to novel molecular anchors.

1996 • 80 citations

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors

2006 • 75 citations

Rapid Evolution of 6-Phenylpurine Inhibitors of Protein Kinase B through Structure-Based Design

2007 • 60 citations

Design and Crystal Structures of Protein Kinase B-Selective Inhibitors in Complex with Protein Kinase A and Mutants

2004 • 57 citations

Discovery of 2-pyrimidyl-5-amidothiophenes as potent inhibitors for AKT: Synthesis and SAR studies

2006 • 41 citations

Structure-based design of isoquinoline-5-sulfonamide inhibitors of protein kinase B

2005 • 38 citations

Deleted Work

1955 • 0 citations