Structure-activity relationship of pyrimidine base analogs as ligands of orotate phosphoribosyltransferase

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

CRC Handbook of Chemistry and Physics

2014 • 56,288 citations

The pharmacological basis of therapeutics

1981 • 2,853 citations

A New Substituent Constant, π, Derived from Partition Coefficients

1964 • 1,353 citations

Pyrimidine metabolism in microorganisms

1970 • 446 citations

Spectrophotometric studies op nucleic acid derivatives and related compounds as a function of pH

1952 • 418 citations

264. Ionization constants of heterocyclic substances. Part II. Hydroxy-derivatives of nitrogenous six-membered ring-compounds

1956 • 332 citations

s-Triazines and derivatives.

1959 • 194 citations

Nucleotide Metabolism: An Introduction

1973 • 169 citations

Taulomerism and Electronic Structure of Biological Pyrimidines

1975 • 166 citations

Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.

1975 • 104 citations

Inhibition of orotidine-5'-phosphate decarboxylase by 1-(5'-phospho-.beta.-D-ribofuranosyl)barbituric acid, 6-azauridine 5'-phosphate, and uridine 5'-phosphate

1980 • 97 citations

Infrared and Ultraviolet Studies on the Tautomeric Equilibria in Aqueous Medium between Monoanionic Species of Uracil, Thymine, 5-Fluorouracil, and Other 2,4-Diketopyrimidines

1965 • 95 citations

Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor

1961 • 94 citations

5-Benzylacyclouridine and 5-benzyloxybenzylacyclouridine, potent inhibitors of uridine phosphorylase

1982 • 91 citations

Spectrometric Studies of Nucleic Acid Derivatives and Related Compounds. VI. On the Structure of Certain 5- and 6-Halogenouracils and -cytosines

1964 • 88 citations

Purification and Kinetic Properties of Brain Orotidine 5′-Phosphate Decarboxylase

1968 • 87 citations

3-Ribosylpurines

1964 • 87 citations

Isolation and initial characterization of the single polypeptide that ssynthesizes uridine 5'-monophosphate from orotate in Ehrlich ascites carcinoma. Purification by tandem affinity chromatography of uridine-5'-monophosphate synthase

1980 • 85 citations

Purification and Properties of Orotic Acid-decarboxylating Enzymes from Calf Thymus

1964 • 71 citations

Absorption Spectra and Structure of Barbituric Acid Derivatives as a Function of pH

1952 • 68 citations

An update on the biochemistry of 5-fluorouracil

1981 • 68 citations

Spectrometric method for the quantitative determination of elemental carbon

1975 • 65 citations

Transport and enzymic splitting of pyrimidine nucleosides in Ehrlich cells

1962 • 63 citations

Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma

1983 • 62 citations

Interconversion of different molecular weight forms of human erythrocyte orotidylate decarboxylase.

1975 • 59 citations

Intrinsic acidities of carbon and nitrogen acids measured by gas phase proton transfer equilibriums. Substituent effects on the stabilities of gas phase carbanions and nitrogen anions

1976 • 58 citations

Synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells

1969 • 58 citations

Enzymic ribosidation and ribotidation of 5-fluorouracil by extracts of the Ehrlich-ascites tumor

1958 • 58 citations

Formation of Uridine Phosphates from Uracil in Extracts of Ehrlich Ascites Tumor.

1957 • 57 citations

Purification, size, and properties of the complex of orotate phosphoribosyltransferase: orotidylate decarboxylase from mouse Ehrlich ascites carcinoma.

1976 • 56 citations

Inhibitors of orotate phosphoribosyl-transferase and orotidine-5'-phosphate decarboxylase from mouse ehrlich ascites cells: a procedure for analyzing the inhibition of a multi-enzyme complex

1977 • 54 citations

Nucleic acid components and their analogues. XVI. Dissociation constants of uracil, 6-azauracil, 5-azauracil and related compounds

1962 • 47 citations

Pyrimidine pathway variants of cultured mouse lymphoma cells with altered levels of both orotate phosphoribosyltransferase and orotidylate decarboxylase.

1979 • 46 citations

STUDIES ON TUMOR RESISTANCE TO 5-FLUOROURACIL.

1963 • 41 citations

The synthesis of 3‐deazapyrimidine nucleosides related to uridine and cytidine and their derivatives

1970 • 40 citations

Effect of allopurinol and oxipurinol on pyrimidine synthesis in cultured human fibroblasts

1971 • 35 citations

Tautomerism of oxopyridines and oxopyrimidines: Theoretical study with complete optimization of geometry

1979 • 28 citations

5-azaorotic acid and related inhibitors of the synthesis de novo of pyrimidine nucleotides.

1963 • 25 citations

Inhibition by barbituric acid and its derivatives of the enzymes in rat brain which participate in the synthesis of pyrimidine ribotides

1978 • 24 citations

Nucleic acid components and their analogues. XIII. Synthesis of 5-azauracil (allantoxaidin) and its N-methyl derivatives

1961 • 24 citations

Eine einfache Synthese des 6-Azauracils und 6-Azathymins

1958 • 24 citations

Mechanism of allopurinol-mediated inhibition and stabilization of human orotate phosphoribosyltransferase and orotidine phosphate decarboxylase

1976 • 23 citations

Effects of 2-thiouracil and related compounds on pyrimidine metabolism

1968 • 22 citations

Simple pyrimidines. VII. The fine structure of 4,6-dihydroxypyrimidine

1964 • 22 citations

Spectrophotometric and Chemical Studies of 5-Mercaptouracil, 5-Mercaptodeoxyuridine, and their S-Substituted Derivatives

1966 • 20 citations

Resistance to 5-fluoroorotic acid and pyrimidine auxotrophy: A new bidirectional selective system for mammalian cells

1979 • 20 citations

Inhibitory effects of 2-thiouracil and 2-thiouracil metabolites on enzymes involved in pyrimidine nucleotide biosynthesis

1974 • 19 citations

Pyrimidine nucleotide biosynthesis. A study of normal and purine enzyme-deficient cells.

1978 • 16 citations

Structure and tautomerism of the neutral and monoanionic forms of 2-thiouracil, 2,4-dithiouracil, their nucleosides, and some related derivatives.

1979 • 14 citations

Metabolic transformations of 5-azauracil and 5-azaorotic acid in mouse liver and escherichia coli

1972 • 13 citations

Equilibrium Studies of 5-Substituted 4-Hydroxy-2-methylpyrimidines. I. The Ionization Constants in Aqueous Solution

1974 • 11 citations

The proton magnetic resonance spectra and the structure of 4,6-dihydroxy-pyrimidine and its derivatives

1967 • 10 citations

The action of some orotic acid analogues on the in vitro incorporation of 14C-orotate into pyrimidine nucleotides

1970 • 10 citations

Spectroscopic studies of 2,6-dihydroxypyridine and some of its derivatives. Tautomerism in solution, and very strong hydrogen bonding in solid 2,6-dihydroxypyridine and its N-methylated derivative

1971 • 10 citations

Studies of the Magnetic Circular Dichroism and Tautomerism of Pyridinols (Pyridinones) and Pyrimidinols (Pyrimidinones)

1980 • 9 citations

Fluorinated pyrimidine aldehydes. Inhibition of nucleic acid and protein biosynthesis in Ehrlich ascites carcinoma cells in vitro

1968 • 7 citations