Identification of the Transmembrane Metal Binding Site in Cu+-transporting PIB-type ATPases

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 Å resolution

2000 • 1,768 citations

Evolution of Substrate Specificities in the P-Type ATPase Superfamily

1998 • 895 citations

Structural changes in the calcium pump accompanying the dissociation of calcium

2002 • 878 citations

Activation by Adenosine Triphosphate in the Phosphorylation Kinetics of Sodium and Potassium Ion Transport Adenosine Triphosphatase

1972 • 826 citations

Escherichia colimechanisms of copper homeostasis in a changing environment

2003 • 692 citations

Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase

1989 • 569 citations

CopA: An Escherichia coli Cu(I)-translocating P-type ATPase

2000 • 497 citations

CPx-type ATPases: a class of P-type ATPases that pump heavy metals

1996 • 472 citations

Altered selectivity in anArabidopsismetal transporter

2000 • 454 citations

Organization of P-type ATPases: significance of structural diversity

1995 • 448 citations

Crystal structure of the calcium pump with a bound ATP analogue

2004 • 437 citations

RESPONSIVE-TO-ANTAGONIST1, a Menkes/Wilson Disease–Related Copper Transporter, Is Required for Ethylene Signaling in Arabidopsis

1999 • 408 citations

Structural basis for E1–E2 conformational transitions in Na, K-pump and Ca-pump proteins

1988 • 338 citations

Biochemical Characterization of the Wilson Disease Protein and Functional Expression in the Yeast Saccharomyces cerevisiae

1997 • 324 citations

PAA1, a P-Type ATPase of Arabidopsis, Functions in Copper Transport in Chloroplasts

2003 • 312 citations

Families of Soft-Metal-Ion-Transporting ATPases

1999 • 273 citations

Identification of Ion-Selectivity Determinants in Heavy-Metal Transport P 1B -type ATPases

2003 • 266 citations

Metallochaperones and Metal-Transporting ATPases: A Comparative Analysis of Sequences and Structures

2002 • 260 citations

Evolution of P-type ATPases

1998 • 241 citations

Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase

1998 • 238 citations

Arabidopsis HMA2, a Divalent Heavy Metal-Transporting PIB-Type ATPase, Is Involved in Cytoplasmic Zn2+ Homeostasis

2004 • 228 citations

The ATP Hydrolytic Activity of Purified ZntA, a Pb(II)/Cd(II)/Zn(II)-translocating ATPase from Escherichia coli

2000 • 212 citations

Function and Regulation of the Mammalian Copper-transporting ATPases: Insights from Biochemical and Cell Biological Approaches

2003 • 206 citations

Functional Expression of the Menkes Disease Protein Reveals Common Biochemical Mechanisms Among the Copper-transporting P-type ATPases

1998 • 158 citations

Molecular characterization of the in situ red cell membrane calcium pump by limited proteolysis.

1986 • 151 citations

Untitled

1998 • 142 citations

Solution Structure of the Yeast Copper Transporter Domain Ccc2a in the Apo and Cu(I)-loaded States

2001 • 134 citations

Characterization of a Thermophilic P-type Ag+/Cu+-ATPase from the ExtremophileArchaeoglobus fulgidus

2002 • 129 citations

Functional Analysis of the N-terminal CXXC Metal-binding Motifs in the Human Menkes Copper-transporting P-type ATPase Expressed in Cultured Mammalian Cells

1999 • 127 citations

Biochemical Characterization of CopA, the Escherichia coli Cu(I)-translocating P-type ATPase

2002 • 126 citations

Functional consequences of alterations to amino acids located in the nucleotide binding domain of the Ca2(+)-ATPase of sarcoplasmic reticulum.

1990 • 115 citations

The Distinct Roles of the N-terminal Copper-binding Sites in Regulation of Catalytic Activity of the Wilson's Disease Protein

2003 • 112 citations

Iron transport by Nramp2/DMT1: pH regulation of transport by 2 histidines in transmembrane domain 6

2003 • 107 citations

Functional Roles of Metal Binding Domains of the Archaeoglobus fulgidus Cu⁺-ATPase CopA

2003 • 106 citations

Archaeoglobus fulgidus CopB Is a Thermophilic Cu2+-ATPase

2003 • 104 citations

Cloning and Membrane Topology of a P type ATPase from Helicobacter pylori

1996 • 101 citations

Asp804 and Asp808 in the Transmembrane Domain of the Na,K-ATPase α Subunit Are Cation Coordinating Residues

1996 • 100 citations

Mutation analysis in patients of Mediterranean descent with Wilson disease: identification of 19 novel mutations.

1999 • 91 citations

Conserved Residues and Motifs in the NixA Protein ofHelicobacter pylori Are Critical for the High Affinity Transport of Nickel Ions

1998 • 81 citations

Mutation to the Glutamate in the Fourth Membrane Segment of Na⁺,K⁺-ATPase and Ca²⁺-ATPase Affects Cation Binding from Both Sides of the Membrane and Destabilizes the Occluded Enzyme Forms

1998 • 81 citations

The Role of the Invariant His-1069 in Folding and Function of the Wilson's Disease Protein, the Human Copper-transporting ATPase ATP7B

2003 • 76 citations

Glutamate 779, an intramembrane carboxyl, is essential for monovalent cation binding by the Na,K-ATPase.

1994 • 75 citations

ATP‐dependent copper transport by the Menkes protein in membrane vesicles isolated from cultured Chinese hamster ovary cells

1998 • 75 citations

Substitutions of Serine 775 in the α Subunit of the Na,K-ATPase Selectively Disrupt K+ High Affinity Activation without Affecting Na+ Interaction

1995 • 72 citations

A comparison of the mutation spectra of Menkes disease and Wilson disease

2004 • 65 citations

Role of Negatively Charged Residues in the Fifth and Sixth Transmembrane Domains of the Catalytic Subunit of Gastric H+,K+-ATPase

1996 • 65 citations

Functional Consequences of Alterations to Amino Acids at the M5S5 Boundary of the Ca -ATPase of Sarcoplasmic Reticulum

1995 • 57 citations

Conformational dynamics of the Na ⁺ /K ⁺ -ATPase probed by voltage clamp fluorometry

2003 • 55 citations

The Cytoplasmic Loop between Putative Transmembrane Segments 6 and 7 in Sarcoplasmic Reticulum Ca2+-ATPase Binds Ca2+ and Is Functionally Important

1997 • 54 citations

Structural Basis for the Function of the N-terminal Domain of the ATPase CopA from Bacillus subtilis

2003 • 51 citations

A Ni2+ Binding Motif Is the Basis of High Affinity Transport of the Alcaligenes eutrophus Nickel Permease

1997 • 50 citations

A Mutational Study in the Transmembrane Domain of Ccc2p, the Yeast Cu(I)-ATPase, Shows Different Roles for Each Cys-Pro-Cys Cysteine

2004 • 45 citations

Substitution of Glutamic 779 with Alanine in the Na,K-ATPase α Subunit Removes Voltage Dependence of Ion Transport

1996 • 41 citations

Membrane topology of the p1258 CadA Cd(II)/Pb(II)/Zn(II)-translocating P-type ATPase.

2002 • 38 citations

Functional Role of Oxygen-Containing Residues in the Fifth Transmembrane Segment of the Na,K-ATPase α Subunit

1999 • 18 citations

Catalytic Phosphorylation of Na,K-ATPase Drives the Outward Movement of Its Cation-Binding H5−H6 Hairpin

2002 • 9 citations

Stabilization in microsomal membranes of the fifth transmembrane segment of the Na⁺,K⁺-ATPase α subunit with proline to leucine mutation

1993 • 4 citations

Abstract

1999 • 1 citations