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CI-1033, an irreversible pan-erbB receptor inhibitor and its potential application for the treatment of breast cancer

Data up to Jan 2025

Published2003
Citations99
References96

Total Citations Per Year

Abstract

References (96)

The Hallmarks of Cancer

2000 • 27,569 citations

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Untangling the ErbB signalling network

2001 • 6,623 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease

1999 • 2,747 citations

Epidermal growth factor-related peptides and their receptors in human malignancies

1995 • 2,689 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

NEW EMBO MEMBERS' REVIEW: The ErbB signaling network: receptor heterodimerization in development and cancer

2000 • 2,394 citations

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1985 • 1,523 citations

The EGF receptor family as targets for cancer therapy

2000 • 1,339 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

1998 • 1,086 citations

A Hierarchical Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor

1996 • 1,021 citations

Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts.

1998 • 1,013 citations

A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity.

1994 • 932 citations

Specificity within the EGF family/ErbB receptor family signaling network

1998 • 804 citations

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

1996 • 772 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand‐receptor interactions

1997 • 719 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

The Clinical Significance of Epidermal Growth Factor Receptor (EGF-R) in Human Breast Cancer: A Review on 5232 Patients*

1992 • 585 citations

Biochemical and Clinical Implications of the ErbB/HER Signaling Network of Growth Factor Receptors

1999 • 548 citations

Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.

1995 • 546 citations

ERBB2 oncogene in human breast cancer and its clinical significance

1998 • 457 citations

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1999 • 445 citations

Trastuzumab, a recombinant DNA-derived humanized monoclonal antibody, a novel agent for the treatment of metastatic breast cancer

1999 • 440 citations

The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors

1999 • 440 citations

Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

1998 • 414 citations

A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis.

1996 • 407 citations

Phase II study of weekly intravenous trastuzumab (Herceptin) in patients with HER2/neu-overexpressing metastatic breast cancer.

1999 • 300 citations

Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group.

1999 • 296 citations

Combination of EGFR, HER-2/neu, and HER-3 is a stronger predictor for the outcome of oral squamous cell carcinoma than any individual family members.

1999 • 293 citations

Receptor tyrosine kinases as targets for anticancer drugs

2002 • 251 citations

Expression of the ERBB3 gene product in breast cancer

1992 • 237 citations

Bivalence of EGF-like ligands drives the ErbB signaling network

1997 • 226 citations

Protein Tyrosine Kinase Inhibitors as Novel Therapeutic Agents

1999 • 217 citations

EGFR family expression in breast carcinomas. c‐erbB‐2 and c‐erbB‐4 receptors have different effects on survival

2001 • 215 citations

Prognostic significance of HER-2/neu oncoprotein expression in node-positive breast cancer. The influence of the pattern of immunostaining and adjuvant therapy

1994 • 212 citations

Transformation of NIH 3T3 Cells by HER3 or HER4 Receptors Requires the Presence of HER1 or HER2

1996 • 208 citations

Erbb4 Signaling in the Mammary Gland Is Required for Lobuloalveolar Development and Stat5 Activation during Lactation

1999 • 192 citations

Roles of Erbb family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival

2002 • 191 citations

Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors as Anticancer Agents

2000 • 191 citations

The Role of the Epidermal Growth Factor Receptor Family in Mammary Tumorigenesis and Metastasis

1999 • 190 citations

Expression of the c-erbB-4/HER4 protein and mRNA in normal human fetal and adult tissues and in a survey of nine solid tumour types

1998 • 188 citations

The role of EGF-related peptides in tumor growth

2001 • 188 citations

Receptor dimerization is not a factor in the signalling activity of a transforming variant epidermal growth factor receptor (EGFRvIII)

1997 • 186 citations

Targeting the epidermal growth factor receptor

2004 • 183 citations

Expression of c-erbB3 protein in primary breast carcinomas

1998 • 181 citations

Prognostic value of the type I growth factor receptors in a large series of human primary breast cancers quantified with a real-time reverse transcription-polymerase chain reaction assay.

2000 • 169 citations

Epiregulin Is a Potent Pan-ErbB Ligand That Preferentially Activates Heterodimeric Receptor Complexes

1998 • 163 citations

The epidermal growth factor receptor as a prognostic marker: Results of 370 patients and review of 3009 patients

1994 • 161 citations

Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers.

2000 • 159 citations

Characterization of neuronal dystrophy induced by fibrillar amyloid β: implications for Alzheimer’s disease

2002 • 149 citations

Unliganded Epidermal Growth Factor Receptor Dimerization Induced by Direct Interaction of Quinazolines with the ATP Binding Site

1997 • 149 citations

Epidermal growth factor receptor vIII enhances tumorigenicity in human breast cancer.

2000 • 147 citations

c-erbB-2 expression and benefit from adjuvant chemotherapy and radiotherapy of breast cancer

1995 • 133 citations

Cardiotoxicity in patients receiving transtuzumab (Herceptin): primary toxicity, synergistic or sequential stress, or surveillance artifact?

1999 • 133 citations

c-erbB3 and c-erbB4 expression is a feature of the endocrine responsive phenotype in clinical breast cancer

1998 • 132 citations

Signal transduction pathways activated and required for mammary carcinogenesis in response to specific oncogenes

1998 • 130 citations

Inhibition of the Epidermal Growth Factor Receptor Family of Tyrosine Kinases as an Approach to Cancer Chemotherapy

1999 • 128 citations

C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators

1996 • 128 citations

Tyrosine kinase signalling in breast cancer

2000 • 128 citations

Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.

2001 • 123 citations

Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor

2000 • 121 citations

c-erbB-4 protein expression in human breast cancer

2000 • 107 citations

Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit thein vitro growth of human head and neck cancer cells and cause rapid tumor regressionin vivo

2000 • 106 citations

Potential benefits of the irreversible pan-erbB inhibitor, CI-1033, in the treatment of breast cancer

2002 • 105 citations

The C-terminus of the kinase-defective neuregulin receptor ErbB-3 confers mitogenic superiority and dictates endocytic routing

1999 • 105 citations

The type 1 growth factor receptor family: new ligands and receptors and their role in breast cancer

1998 • 97 citations

c‐erbB‐2/EGFR as dominant heterodimerization partners determine a motogenic phenotype in human breast cancer cells

1999 • 96 citations

Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo.

1999 • 85 citations

Targeting the epidermal growth factor receptor: a clinical reality.

2001 • 84 citations

Biological Response to ErbB Ligands in Nontransformed Cell Lines Correlates with a Specific Pattern of Receptor Expression

1998 • 82 citations

Cripto: a novel epidermal growth factor (EGF)-related peptide in mammary gland development and neoplasia

1999 • 80 citations

The c-erbB3/HER3 receptor in human cancer.

1996 • 72 citations

Expression of erbB-4/HER-4 growth factor receptor isoforms in ovarian cancer.

2001 • 72 citations

Site-directed irreversible inhibitors of the erbB family of receptor tyrosine kinases as novel chemotherapeutic agents for cancer.

2000 • 70 citations

The epidermal growth factor receptor in breast cancer.

1997 • 64 citations

Clinical and prognostic significance of the expression of the c-erbB-2 and c-erbB-3 oncoproteins in primary and metastatic malignant melanomas and breast carcinomas.

1997 • 62 citations

EGF-related peptides and their receptors in mammary gland development.

1997 • 59 citations

Evidence for epidermal growth factor receptor-enhanced chemosensitivity in combinations of cisplatin and the new irreversible tyrosine kinase inhibitor CI-1033

2001 • 55 citations

EGF-R expression in ductal breast cancer: proliferation and prognostic implications.

1997 • 47 citations

The combination of in situ hybridization and immunohistochemical analysis: an evaluation of Her2/neu expression in paraffin-embedded breast carcinomas and adjacent normal-appearing breast epithelium.

1997 • 45 citations

Amplification of erbB-4 oncogene occurs less frequently than that of erbB-2 in primary human breast cancer1Published in conjunction with A Wisconsin Gathering Honoring Waclaw Szybalski on the occasion of his 75th year and 20 years of Editorship-in-Chief of Gene, 10–11 August, 1997, University of Wisconsin, Madison, WI, USA.1

1998 • 44 citations

The ErbB/HER family of receptor tyrosine kinases: A potential target for chemoprevention of epithelial neoplasms

2000 • 44 citations

Epidermal growth factor receptor in breast cancer. Comparison with non malignant breast tissue

1993 • 39 citations

Intermolecular association and trans-phosphorylation of different neu-kinase forms permit SH2-dependent signaling and oncogenic transformation.

1995 • 33 citations

Tyrosine kinase signalling in breast cancer: Modulation of tyrosine kinase signalling in human breast cancer through altered expression of signalling intermediates

2000 • 26 citations

What went wrong with Iressa?

2002 • 23 citations

ErbB-4: a receptor tyrosine kinase

2002 • 22 citations

ErbB receptor tyrosine kinase inhibitors as therapeutic agents

2002 • 20 citations

The ErbB 2 Oncogene and Chemotherapy: a Mini-Review

1997 • 19 citations

EGF Family Receptors and Their Ligands in Human Cancer

1998 • 19 citations

Deleted Work

1955 • 0 citations

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CI-1033, an irreversible pan-erbB receptor inhibitor and its potential application for… (2003) – Seminars in Oncology | Metascience Observatory Explorer