KiSS-1 Represses 92-kDa Type IV Collagenase Expression by Down-regulating NF-κB Binding to the Promoter as a Consequence of IκBα-induced Block of p65/p50 Nuclear Translocation

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis.

2000 • 1,945 citations

MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes

1998 • 1,753 citations

Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis

2000 • 1,604 citations

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

SV40-transformed Human Lung Fibroblasts Secrete a 92-kDa Type IV Collagenase Which Is Identical to That Secreted by Normal Human Macrophages

1989 • 1,122 citations

H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.

1988 • 1,050 citations

KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene

1996 • 1,013 citations

KAI1 , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2

1995 • 757 citations

Regulatory mechanism of 92 kDa type IV collagenase gene expression which is associated with invasiveness of tumor cells.

1993 • 704 citations

Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

1992 • 519 citations

Multiple signals converging on NF-κB

1999 • 483 citations

c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases.

1994 • 463 citations

Control of type IV collagenase activity by components of the urokinase-plasmin system: a regulatory mechanism with cell-bound reactants

1997 • 427 citations

The atypical PKC-interacting protein p62 channels NF-kappa B activation by the IL-1-TRAF6 pathway

2000 • 422 citations

Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.

1994 • 395 citations

The interaction of p62 with RIP links the atypical PKCs to NF-kappa B activation

1999 • 394 citations

Suppression of metastasis in human breast carcinoma MDA-MB-435 cells after transfection with the metastasis suppressor gene, KiSS-1.

1997 • 368 citations

Stimulation of 92-kDa Gelatinase B Promoter Activity by ras Is Mitogen-activated Protein Kinase Kinase 1-independent and Requires Multiple Transcription Factor Binding Sites Including Closely Spaced PEA3/ets and AP-1 Sequences

1996 • 351 citations

Complete structure of the human gene for 92-kDa type IV collagenase. Divergent regulation of expression for the 92- and 72-kilodalton enzyme genes in HT-1080 cells.

1991 • 343 citations

Localization of messenger RNA for Mr 72,000 and 92,000 type IV collagenases in human skin cancers by in situ hybridization.

1992 • 331 citations

Activation of progelatinase B (MMP-9) by gelatinase A (MMP-2).

1995 • 324 citations

Structure of the human type IV collagenase gene.

1990 • 310 citations

In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13.

1997 • 300 citations

Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase

1994 • 294 citations

v-Src activates the expression of 92-kDa type IV collagenase gene through the AP-1 site and the GT box homologous to retinoblastoma control elements. A mechanism regulating gene expression independent of that by inflammatory cytokines.

1993 • 291 citations

Kinetic Analysis of the Binding of Human Matrix Metalloproteinase-2 and -9 to Tissue Inhibitor of Metalloproteinase (TIMP)-1 and TIMP-2

1997 • 279 citations

Increased incidence of matrix metalloproteinases in urine of cancer patients.

1998 • 258 citations

Regulation of 92 kDa type IV collagenase expression by the jun aminoterminal kinase- and the extracellular signal-regulated kinase-dependent signaling cascades

1997 • 233 citations

Airway Epithelial Cell Migration Dynamics: MMP-9 Role in Cell–Extracellular Matrix Remodeling

1999 • 233 citations

Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2

1997 • 217 citations

Inhibition of matrix metalloproteinase 9 expression by a ribozyme blocks metastasis in a rat sarcoma model system.

1996 • 217 citations

Chromosome Localization and Genomic Structure of the KiSS-1 Metastasis Suppressor Gene (KISS1)

1998 • 208 citations

Sustained Activation of the Mitogen-activated Protein Kinase Pathway

1999 • 205 citations

Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.

1990 • 202 citations

Novel Regulation of Type IV Collagenase (Matrix Metalloproteinase-9 and -2) Activities by Transforming Growth Factor-β1 in Human Prostate Cancer Cell Lines

1999 • 163 citations

Transcription of a novel mouse semaphorin gene, M-semaH, correlates with the metastatic ability of mouse tumor cell lines.

1998 • 145 citations

Loss of KAI1 expression in the progression of colorectal cancer.

1999 • 130 citations

Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-kB

1995 • 123 citations

Suppression of invasive properties of colon cancer cells by a metastasis suppressor KAI1 gene

1998 • 115 citations

The rabbit gene for 92-kDa matrix metalloproteinase. Role of AP1 and AP2 in cell type-specific transcription.

1994 • 109 citations

Transcriptional activation of the matrix metalloproteinase-9 gene in an H-ras and v-myc transformed rat embryo cell line

1997 • 106 citations

Gelatinase B/lacZ Transgenic Mice, a Model for Mapping Gelatinase B Expression during Developmental and Injury-related Tissue Remodeling

1998 • 98 citations

Analysis of Expression of Matrix Metalloproteinases-2 and −9 in Hypopharyngeal Squamous Cell Carcinoma by in Situ Hybridization

1995 • 82 citations

Production of matrix metalloproteinase 9 (92-kDa gelatinase) by human oesophageal squamous cell carcinoma in response to epidermal growth factor

1993 • 73 citations

Transcriptional Induction of the Urokinase Receptor Gene by a Constitutively Active Src

1999 • 72 citations

Expression of antisense CD44 variant 6 inhibits colorectal tumor metastasis and tumor growth in a wound environment.

1998 • 70 citations

Tumor Necrosis Factor-α Activation of NF-κB Requires the Phosphorylation of Ser-471 in the Transactivation Domain of c-Rel

2000 • 69 citations

Cyclic AMP-regulated synthesis of the tissue inhibitors of metalloproteinases suppresses the invasive potential of the human fibrosarcoma cell line HT1080.

1995 • 68 citations

On the structure and chromosome location of the 72- and 92-kDa human type IV collagenase genes

1991 • 66 citations

Co-purification of mitogen-activated protein kinases with phorbol ester-induced c-Jun kinase activity in U937 leukaemic cells.

1993 • 65 citations

Tumor cell contact mediated transcriptional activation of the fibroblast matrix metalloproteinase-9 gene: involvement of multiple transcription factors including Ets and an alternating purine-pyrimidine repeat.

1997 • 61 citations

Human immunodeficiency virus‐1‐tat induces matrix metalloproteinase‐9 in monocytes through protein tyrosine phosphatase‐mediated activation of nuclear transcription factor NF‐κB

1999 • 58 citations

Expression of Matrix Metalloproteinase-9 in Squamous Cell Carcinoma of the Uterine Cervix—Clinicopathologic Study Using Immunohistochemistry and mRNAin SituHybridization

1999 • 56 citations

Murine Matrix Metalloproteinase 9 Gene

1999 • 53 citations

Involvement of transforming growth factor beta1 in autocrine enhancement of gelatinase B secretion by murine metastatic colon carcinoma cells.

1996 • 51 citations

Regulation of urokinase‐type plasminogen activator expression in squamous‐cell carcinoma of the oral cavity

1993 • 49 citations

Activations of mitogen-activated protein kinases and phospholipase D in A7r5 vascular smooth muscle cells.

1994 • 42 citations

Keratinocyte Growth Factor Stimulation of Gelatinase (Matrix Metalloproteinase-9) and Plasminogen Activator in Histiotypic Epithelial Cell Culture

1995 • 42 citations

Identification of a tumor-associated mutant form of the NF-κB RelA gene with reduced DNA-binding and transactivating activities

1997 • 34 citations

Examination of urokinase protein/transcript levels and their relationship with laminin degradation in cultured colon carcinoma.

1989 • 34 citations

Insensitivity of Laminin Degradation Directed by Receptor Bound Urokinase to PAI-1 in Cultured Colon Cancer

1990 • 32 citations

Poly-L-Ornithine-Mediated Transfection of Human Keratinocytes

1995 • 31 citations

Reassignment of the 92-kDa type IV collagenase gene (CLG4B) to human chromosome 20

1996 • 19 citations