Increased 5-HT release mediates the anxiogenic response during benzodiazepine withdrawal: a review of supporting neurochemical and behavioural evidence

Withdrawal from long-term benzodiazepine treatment.

1981 • 368 citations

The 5-HT1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo

1988 • 296 citations

Tianeptine, a selective enhancer of serotonin uptake in rat brain

1987 • 209 citations

Tolerance to the behavioral actions of benzodiazepines

1985 • 200 citations

Tianeptine stimulates uptake of 5-hydroxytryptamine in vivo in the rat brain

1990 • 127 citations

The history of benzodiazepine dependence: A review of animal studies

1990 • 100 citations

Sites of action of ondansetron to inhibit withdrawal from drugs of abuse

1990 • 96 citations

The effect of the novel antidepressant tianeptine on the concentration of 5-hydroxytryptamine in rat hippocampal dialysates in vivo

1991 • 70 citations

An investigation into the mechanisms of inhibition of calcium channel currents in cultured sensory neurones of the rat by guanine nucleotide analogues and (−)− baclofen

1989 • 69 citations

A Double-Blind Placebo-Controlled Study of Buspirone in Diazepam Withdrawal in Chronic Benzodiazepine Users

1990 • 66 citations

The effects of ondansetron (GR38032F) in rats and mice treated subchronically with diazepam

1989 • 59 citations

GABA_B‐receptor mediated inhibition of potassium‐evoked release of endogenous 5‐hydroxytryptamine from mouse frontal cortex

1987 • 57 citations

Low but not high doses of buspirone reduce the anxiogenic effects of diazepam withdrawal

1991 • 55 citations

The differential activities of R(+)- and S(−)-zacopride as 5-HT3 receptor antagonists

1990 • 55 citations

Dependence as a limiting factor in the clinical use of minor tranquillizers

1988 • 52 citations

Differential modulation of extracellular levels of 5‐hydroxytryptamine in the rat frontal cortex by (R)‐ and (S)‐zacopride

1992 • 46 citations

Diazepam withdrawal responses measured in the social interaction test of anxiety and their reversal by baclofen

1991 • 43 citations

Dependence liability of the benzodiazepines

1984 • 39 citations

Chronic diazepam treatment in rats causes long‐lasting changes in central [³H]‐5‐hydroxytryptamine and [¹⁴C]‐γ‐aminobutyric acid release

1990 • 38 citations

Reversal by alpha-2 agonists of diazepam withdrawal hyperactivity in rats

1986 • 35 citations

Buspirone: Anxiolytic?

1985 • 34 citations

The potent 5-HT3 receptor antagonist (R)-zacopride labels an additional high affinity site in the central nervous system

1992 • 30 citations

Studies on the emetic and antiemetic properties of zacopride and its enantiomers

1991 • 28 citations

Anxiolytic-like activity of R(+)- and S(−)-zacopride in mice

1991 • 27 citations

Are there changes in sensitivity to 5-HT3 receptor ligands following chronic diazepam treatment?

1992 • 26 citations

Evidence that the increased anxiety detected in the elevated plus-maze during chlordiazepoxide withdrawal is not due to enhanced noradrenergic activity

1989 • 23 citations

Raised [3H]-5-HT release and 45Ca2+ uptake in diazepam withdrawal: Inhibition by baclofen

1992 • 19 citations

Tianeptine counteracts the anxiogenic effects of benzodiazepine withdrawal, but not those of exposure to cat odour

1993 • 6 citations

EVALUATION OF ANXIOLYTICS IN NORMALS AND PATIENTS

1992 • 1 citations