Posttranscriptional Gene Regulation by Spatial Rearrangement of the 3′ Untranslated Region

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 • 4,334 citations

The Nonsense-Mediated Decay RNA Surveillance Pathway

2007 • 1,219 citations

PTC124 targets genetic disorders caused by nonsense mutations

2007 • 1,075 citations

Evidence for the widespread coupling of alternative splicing and nonsense-mediated mRNA decay in humans

2002 • 1,026 citations

From Birth to Death: The Complex Lives of Eukaryotic mRNAs

2005 • 991 citations

Nonsense-mediated mRNA decayin health and disease

1999 • 974 citations

Circularization of mRNA by Eukaryotic Translation Initiation Factors

1998 • 940 citations

Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise

2004 • 834 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

Binding of a novel SMG-1–Upf1–eRF1–eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay

2006 • 596 citations

Nonsense-mediated decay approaches the clinic

2004 • 582 citations

Quality control of eukaryotic mRNA: safeguarding cells from abnormal mRNA function

2007 • 575 citations

Human Upf Proteins Target an mRNA for Nonsense-Mediated Decay When Bound Downstream of a Termination Codon

2000 • 571 citations

Evidence for a Pioneer Round of mRNA Translation

2001 • 558 citations

A faux 3′-UTR promotes aberrant termination and triggers nonsense- mediated mRNA decay

2004 • 504 citations

Mammalian Staufen1 Recruits Upf1 to Specific mRNA 3′UTRs so as to Elicit mRNA Decay

2005 • 474 citations

Genome-Wide Analysis of mRNAs Regulated by the Nonsense-Mediated and 5′ to 3′ mRNA Decay Pathways in Yeast

2003 • 402 citations

Mechanistic links between nonsense-mediated mRNA decay and pre-mRNA splicing in mammalian cells

2005 • 402 citations

Binary specification of nonsense codons by splicing and cytoplasmic translation

1998 • 396 citations

Life and death in the cytoplasm: messages from the 3′ end

1997 • 335 citations

A Competition between Stimulators and Antagonists of Upf Complex Recruitment Governs Human Nonsense-Mediated mRNA Decay

2008 • 324 citations

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways

2008 • 302 citations

Nonsense-mediated mRNA decay in Drosophila:at the intersection of the yeast and mammalian pathways

2003 • 284 citations

Early nonsense: mRNA decay solves a translational problem

2006 • 280 citations

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets

2005 • 255 citations

EJC-independent degradation of nonsense immunoglobulin-μ mRNA depends on 3′ UTR length

2006 • 253 citations

Identification and Characterization of Human Orthologues to Saccharomyces cerevisiae Upf2 Protein and Upf3 Protein (Caenorhabditis elegans SMG-4)

2001 • 245 citations

hUPF2 Silencing Identifies Physiologic Substrates of Mammalian Nonsense-Mediated mRNA Decay

2006 • 233 citations

Upf1p, Nmd2p, and Upf3p Are Interacting Components of the Yeast Nonsense-Mediated mRNA Decay Pathway

1997 • 229 citations

A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay

2007 • 219 citations

A GFP-based reporter system to monitor nonsense-mediated mRNA decay

2005 • 217 citations

Genetic and Biochemical Characterization of Mutations in the ATPase and Helicase Regions of the Upf1 Protein

1996 • 214 citations

Staufen1 regulates diverse classes of mammalian transcripts

2007 • 192 citations

Yeast Upf Proteins Required for RNA Surveillance Affect Global Expression of the Yeast Transcriptome

1999 • 190 citations

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay

2000 • 181 citations

Novel Upf2p Orthologues Suggest a Functional Link between Translation Initiation and Nonsense Surveillance Complexes

2000 • 169 citations

Structural and functional insights into the human Upf1 helicase core

2006 • 161 citations

Mechanistic insights and identification of two novel factors in the C. elegans NMD pathway

2007 • 156 citations

Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay

2008 • 152 citations

Looking at mRNA decay pathways through the window of molecular evolution

2003 • 142 citations

Nonsense-mediated mRNA decay: target genes and functional diversification of effectors

2006 • 134 citations

mRNA surveillance in eukaryotes: Kinetic proofreading of proper translation termination as assessed by mRNP domain organization?

1999 • 111 citations

Quality control of gene expression: a stepwise assembly pathway for the surveillance complex that triggers nonsense-mediated mRNA decay

2006 • 103 citations

eIF4G is required for the pioneer round of translation in mammalian cells

2004 • 90 citations

The Yeast Nuclear Cap Binding Complex Can Interact with Translation Factor eIF4G and Mediate Translation Initiation

2000 • 87 citations

The role of SMG-1 in nonsense-mediated mRNA decay

2005 • 78 citations

Efficient downregulation of immunoglobulin mRNA with premature translation-termination codons requires the 5'-half of the VDJ exon

2004 • 75 citations

In vivo aggregation properties of the nuclear poly(A)-binding protein PABPN1

2005 • 67 citations

The canonical UPF1-dependent nonsense-mediated mRNA decay is inhibited in transcripts carrying a short open reading frame independent of sequence context

2006 • 46 citations

Nonsense-associated alternative splicing of T-cell receptor β genes: No evidence for frame dependence

2004 • 24 citations