The NK1 receptor mediates both the hyperalgesia and the resistance to morphine in mice lacking noradrenaline

Endogenous Pain Control Systems: Brainstem Spinal Pathways and Endorphin Circuitry

1984 • 2,580 citations

Altered nociception, analgesia and aggression in mice lacking the receptor for substance P

1998 • 757 citations

Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome

2001 • 755 citations

Wind-up of spinal cord neurones and pain sensation: much ado about something?

2000 • 679 citations

Elevated cerebrospinal fluid levels of substance p in patients with the fibromyalgia syndrome

1994 • 677 citations

Inhibition of Hyperalgesia by Ablation of Lamina I Spinal Neurons Expressing the Substance P Receptor

1997 • 622 citations

Primary afferent tachykinins are required to experience moderate to intense pain

1998 • 587 citations

Cerebrospinal fluid biogenic amine metabolites in fibromyalgia/fibrositis syndrome and rheumatoid arthritis

1992 • 545 citations

Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia: new features for diagnosis

1988 • 426 citations

μ Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality

1998 • 332 citations

Descending noradrenergic influences on pain

1991 • 302 citations

Assessment of the role of α₂‐adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice

1997 • 291 citations

The α_2aAdrenergic Receptor Subtype Mediates Spinal Analgesia Evoked by α₂Agonists and Is Necessary for Spinal Adrenergic–Opioid Synergy

1997 • 275 citations

Classification, epidemiology, and natural history of fibromyalgia

2001 • 253 citations

Noradrenergic inhibition of the release of substance P from the primary afferents in the rabbit spinal dorsal horn

1985 • 231 citations

Differential Distribution of α_2Aand α_2CAdrenergic Receptor Immunoreactivity in the Rat Spinal Cord

1998 • 220 citations

Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms

1991 • 208 citations

Antinociceptive interactions between alpha 2-adrenergic and opiate agonists at the spinal level in rodents.

1989 • 196 citations

The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models

1998 • 194 citations

Restoration of Norepinephrine and Reversal of Phenotypes in Mice Lacking Dopamine β‐Hydroxylase

1998 • 188 citations

α_2C-Adrenergic Receptors Mediate Spinal Analgesia and Adrenergic-Opioid Synergy

2002 • 171 citations

Antinociceptive Interactions Between Alphha2-Adrenergic and Opiate Agonists at the Spinal Level in Rodents

1989 • 168 citations

Effect of intrathecally administered noradrenergic antagonists on nociception in the rat

1984 • 134 citations

Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing

1999 • 128 citations

Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin

1994 • 122 citations

Potentiated Opioid Analgesia in Norepinephrine Transporter Knock-Out Mice

2000 • 121 citations

Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo

1989 • 111 citations

Disruption of the dopamine Β-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory.

1997 • 96 citations

Disruption of the dopamine Β-hydroxylase gene in mice suggests roles for norepinephrine in motor function, learning, and memory.

1997 • 91 citations

Release of calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal polypeptide (VIP) from rat spinal cord: Modulation by agonists

1993 • 84 citations

Interaction of intrathecal morphine and ST-91 on antinociception in the rat: dose-response analysis, antagonism and clearance.

1990 • 82 citations

Spinal Opioid Analgesia: How Critical Is the Regulation of Substance P Signaling?

1999 • 79 citations

Intrathecally injected neurotrophins and the release of substance P from the rat isolated spinal cord

2000 • 70 citations

Novel aspects of pain management : opioids and beyond

1999 • 69 citations

Novel Aspects of Pain Management: Opioids and Beyond.

2000 • 66 citations

Monoaminergic control of the release of calcitonin gene-related peptide- and substance P-like materials from rat spinal cord slices

1993 • 58 citations

Afferent volley patterns and the spinal release of immunoreactive substance P in the dorsal horn of the anaesthetized spinal cat

1995 • 52 citations

Coexistence and Cooperation between Neuropeptide Y and Norepinephrine in Nerve Fibers of Guinea Pig Vas Deferens and Seminal Vesicle1

1987 • 49 citations

Desensitization to intrathecal substance P in mice: possible involvement of opioids

1988 • 34 citations

Substance P, injected intrathecally, antagonizes the spinal antinociceptive effect of morphine, baclofen and noradrenaline

1984 • 34 citations

Effect of chronic treatment with tricyclic antidepressants upon antinociception induced by intrathecal injection of morphine and monoamines

1988 • 34 citations

Effect of 6-hydroxydopamine-induced lesions to ascending and descending noradrenergic pathways on morphine analgesia

1987 • 32 citations

Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing

1996 • 32 citations

Intrathecal DSP4 selectively depletes spinal noradrenaline and attenuates morphine analgesia

1985 • 31 citations

Changes in nociception after 6-hydroxydopamine lesions of descending catecholaminergic pathways in mice

1986 • 27 citations

Potentiation of morphine analgesia by D-amphetamine is mediated by norepinephrine and not dopamine

1988 • 23 citations

Evidence that substance P may be a modulator rather than a transmitter of noxious mechanical stimulation

1986 • 21 citations

Substance P receptor desensitization in the dorsal horn: possible involvement of receptor-G protein complexes

1993 • 20 citations

Presence of neuropeptide Y in the rat seminal vesicle and its effects on noradrenaline‐ and nerve‐induced contractions

1994 • 15 citations

Differential effects of the novel analgesic, S 12813-4, on the spinal release of substance P- and calcitonin gene-related peptide-like materials in the rat

1994 • 12 citations

Examination of tonic nociceptive behavior using a method of substance P-receptor desensitization in the dorsal horn

1994 • 12 citations

Limited involvement of central noradrenergic pathways in morphine-induced antinociception

1984 • 11 citations

Laser Doppler Perfusion Imaging of Synovial Tissues Using Red and Near Infra-Red Lasers

1997 • 10 citations